Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome by Jingru Sui, Dan Guo, Xiao Wen, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu

“…To address these questions, a computational method called SMNPLS (Sparse Multi‐Network Regularized Partial Least Squares) is developed to uncover the pan‐cancer splicing dysregulation landscape by extracting joint modular patterns from paired matrices of splicing factors (SFs) expressions and alternative splicing events (ASEs). …”
Get full text

Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein by Ziyuan Niu, Georgios Kementzidis, Miriam Rafailovich, Marcia Simon, Evangelos Papadopoulos, Bertal H. Aktas, Yuefan Deng

“…This effect is primarily pH-driven at extreme acidity and thermo-driven at moderate pH. 3) The Gibbs free energy landscape reveals that pH as the main driver of structural changes. 4) The parametrized methods enable the predictions of the S-protein properties at any reasonable pH and thermal conditions without explicit MD simulations.…”
Get full text

Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol by Grace Lu-Yao, Jennifer M Johnson, Amy L Shaver, Nikita Nikita, Swapnil Sharma, Daniel S Lefler, Atrayee Basu-Mallick, Meghan L Butryn

“…Introduction Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple cancer types. Sex plays an important role in both the development of cancer as well as the functioning of the immune system. …”
Get full text

Development of Arabic Language Learning Research: A Bibliometric Study on Scopus (2009-2024) by Ramadhan Safrudin, Ade Nandang, Sri Dewi Priwarti Siregar, Izzuddin Musthafa, Muhamad Fauzan Fauzi, Moch. Hazmi Farhanul Alby, Suyono Suyono

“…This study maps the current landscape of Arabic language learning research, identifies key areas for future investigation, and encourages collaboration among scholars to advance Arabic language education globally.…”
Get full text

Estimating Aggregate Capacity of Connected DERs and Forecasting Feeder Power Flow With Limited Data Availability by Amir Reza Nikzad, Amr Adel Mohamed, Bala Venkatesh, John Penaranda

“…Accurate estimation of the aggregate connected DER capacity becomes pivotal in such a landscape. However, forecasting, power flow analysis, and optimization of feeders for operational decision-making by individually modeling each of these numerous renewables in the absence of complete information are operationally challenging and technically impractical. …”
Get full text

Hybrid learning in post-pandemic higher education systems: an analysis using SEM and DNN by Alvin Muhammad ‘Ainul Yaqin, Ahmad Kamil Muqoffi, Sigit Rahmat Rizalmi, Faishal Arham Pratikno, Remba Yanuar Efranto

“…This research provides valuable empirical evidence to inform education policymakers, institutions, and stakeholders navigating the evolving landscape of post-pandemic learning environments.…”
Get full text

The Use of Awabe’s English Pronunciation Application in Teaching Speaking by Anggitha Juliya Utami, Regina, Wardah

“… The necessity for effective tools to teach speaking skills to students remains essential due to the rapidly evolving landscape of language education. This article aims to assess the effectiveness of Awabe's English pronunciation application in teaching speaking, particularly segmental features pronunciation to the 8th grade students. …”
Get full text

Textural analysis and artificial intelligence as decision support tools in the diagnosis of multiple sclerosis – a systematic review by Filip Orzan, Ştefania D. Iancu, Laura Dioşan, Zoltán Bálint

“…The study emphasizes common models, including U-Net, Support Vector Machine, Random Forest, and K-Nearest Neighbors, alongside their evaluation metrics.ResultsThe analysis revealed a fragmented research landscape, with significant variation in model architectures and performance. …”
Get full text

Conservation value and ecosystem service provision of Nothofagus antarctica forests based on phenocluster categories by Guillermo J. Martínez Pastur, Julián Rodríguez-Souilla, Yamina M. Rosas, Natalia Politi, Luis Rivera, Eduarda M. O. Silveira, Ashley M. Olah, Anna M. Pidgeon, María V. Lencinas, Pablo L. Peri

“…Conservation value and capacity to supply ES significantly varied among phenocluster categories: (i) cultural, regulating, and provisioning ES and potential biodiversity at landscape level, (ii) soil carbon and nitrogen, (iii) dominant height, crown cover, basal area, total volume, and domestic animal stock, and (iv) understory plant richness and cover at stand level. …”
Get full text

The Maritime Cultural Ecology of the Biak People: A Historical Study of the Sowek Region, Supiori Regency, Papua by Endang Susilowati, Haryono Rinardi, Albert Rumbekwan, Ismail Ali, Rabith Jihan Amaruli

“…Supiori Regency is predominantly oceanic and covered by mangrove forests, with only 25% of its land being dry. This landscape has shaped the Sowek people's reliance on marine resources and maritime trade. …”
Get full text

Chromatin accessibility and differentially expressed genes profiling in large yellow croaker (Larimichthys crocea) head kidney cells following iridovirus infection by Chaowei Song, Ying Huang, Fang Han, Zhiyong Wang, Zhiyong Wang

“…This study provides a comprehensive analysis of the epigenomic landscape and gene expression regulation during iridovirus infection in L. crocea, offering valuable insights for breeding programs aimed at combating iridovirus infections.…”
Get full text

Natural selection and adaptive traits in the Maniq, a nomadic hunter-gatherer society from Mainland Southeast Asia by Tobias Herzog, Maximilian Larena, Wibhu Kutanan, Helmut Lukas, Martin Fieder, Helmut Schaschl

“…These results reveal the intricate interplay of positive and balancing selection in shaping the genetic landscape of the Maniq population and highlight their adaptations to the ecological and lifestyle challenges of life in the rainforest. …”
Get full text

Advancing risk assessment in renewable power plant construction: an integrated DEA-SVM approach by Reza Rasinojehdehi, Seyyed Najafi

“…Subsequently, a SVM is developed to monitor the process, concluding with tailored risk treatment and monitoring processes specifically designed for the unique context of Iran's solar energy landscape.…”
Get full text

Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps by Venera Cristina Dinescu, Liviu Martin, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Marius Bunescu, Mihai Andrei Ruscu, Madalina Aldea, Alexandra Daniela Rotaru-Zavaleanu

“…These innovations have the potential to redefine the treatment landscape, significantly enhancing patient care and quality of life.…”
Get full text

Governmental approaches to food security management: A bibliometric analysis by Eldar Guliyev, Bayali Atashov, Aygun Guliyeva

“…Recognizing the critical importance of this imperative, this study aims to conduct a bibliometric analysis that sheds light on the scientific landscape of strategic public administration of food security. …”
Get full text

BanglaBlend: A large-scale nobel dataset of bangla sentences categorized by saint and common form of bangla languageMendeley Data by Umme Ayman, Chayti Saha, Azmain Mahtab Rahat, Sharun Akter Khushbu

“…In the vibrant linguistic landscape of Bengali, spoken by millions in Bangladesh and India, the gap between saintly and common terms is culturally and computationally significant. …”
Get full text

Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…Our findings underscore the importance of analyzing NSCLC histological subtypes separately when investigating the spatial immune landscape, as microenvironmental characteristics and cellular interactions differed by subtype. …”
Get full text

Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…Methods Leveraging multiple single-cell datasets, we constructed a comprehensive dental pulp cell landscape to delineate tissue similarities and species-specific differences between humans and mice. …”
Get full text

Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…IFI30 emerges as a prospective intervention point in the immunotherapeutic landscape.…”
Get full text

POST-PANDEMIC TRADE FAIR DYNAMICS: A LONGITUDINAL STUDY OF EXHIBITORS' VIEWS ON DIGITAL AND HYBRID TRADE FAIRS by Dimitris KOURKOURIDIS, Ioannis FRANGOPOULOS, Asimenia SALEPAKI

“…Future research should delve deeper into specific factors influencing exhibitor satisfaction and engagement in hybrid environments, informing ongoing adaptations to the evolving trade fair landscape.…”
Get full text