Water quality characteristics of municipal wastewater treatment plants and the prospect of reclaimed water utilization in lower-middle income and water-scarce areas: A case study o... by Yutong Duan, Hongbo Xi, Zhikai Qin, Ruili Guo, Fang Wang, Yue Yuan

“…Environmental assessments confirmed that treated water met industrial and landscape irrigation standards, while social and economic analyses showed that cost-effective water reuse offered advantages over other unconventional water sources. …”
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Genome assembly of an endemic butterfly (Minois aurata) shed light on the genetic mechanisms underlying ecological adaptation to arid valley habitat by Wenqian Hu, Yi Wang, Xiaoxiao Chen, Jialong Huang, Jingge Kuang, Lei Wang, Kangshan Mao, Liang Dou

“…Abstract Background The Hengduan Mountains, one of the global biodiversity hotspots with exceptional species richness and high endemism, contains numerous arid valleys that create a distinctive geographical and ecological landscape. However, the adaptive evolutionary mechanisms of organism in the arid valley remain poorly understood. …”
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Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia by Anmut Endalkachew Bezie, Girum Tareke Zewude, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Asmare Asrat Yirdaw, Alebachew Bitew Abie, Giziew Abere

“…To address this issue, interventions focused at reducing work–family conflicts, increasing job satisfaction, and improving the school environment are necessary to support teachers’ well-being, benefiting both young students and the broader educational landscape.…”
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Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing by Alice Perucca, Andrea Gómez Llonín, Oriol Mañé Benach, Clement Hallopeau, Elisa I. Rivas, Jenniffer Linares, Marta Garrido, Anna Sallent-Aragay, Tom Golde, Julien Colombelli, Eleni Dalaka, Judith Linacero, Marina Cazorla, Teresa Galan, Jordi Pastor Viel, Xavier Badenas, Alba Recort-Bascuas, Laura Comerma, Patricia Fernandez-Nogueira, Ana Rovira, Pere Roca-Cusachs, Joan Albanell, Xavier Trepat, Alexandre Calon, Anna Labernadie

“…Collectively, our study underscores the translational value of MIRO as a powerful tool for exploring how the spatial organisation of the tumour microenvironment shapes the immune landscape and influences the responses to immunomodulating therapies.…”
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Call to Action: Lead Pharmacy into the Next Decade by Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Gregory Zumach

“…Traditional written manuscripts are valuable but may not fully connect with some people. The evolving landscape of healthcare leadership demands novel perspectives, creative applications, and open-minded evaluations. …”
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Vertical distribution and variability of soil organic carbon and CaCO3 in deep Colluvisols modeled by hyperspectral imaging by Jessica Reyes-Rojas, Julien Guigue, Daniel Žížala, Vít Penížek, Tomáš Hrdlička, Petra Vokurková, Aleš Vaněk, Tereza Zádorová

“…The acceleration of soil erosion in undulating landscapes due to human activities has led to a larger area of land being affected by intensive soil redistribution. …”
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Trends, challenges and solutions of digital information security in Central and Eastern Europe by Serhii Lubenets, Igor Harchenko, Tetiana Shediakova

“…Conclusions: the obtained results made it possible to understand the current landscape of cyber security in Central and Eastern Europe in general. …”
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Exploring the decline in health index of the Qarhan salt lake region in Qinghai Province, China: A 40-year assessment by Pengfei Ji, Qian Shen, Ru Wang, Yue Yao, Bing Zhang, Wenting Xu, Yuting Zhang, Wenqi Kou, Wenxin Li

“…The primary factors influencing the SLHI include shoreline and landscape changes and land use variations. The health assessment method established in this study will enhance understanding of salt lake health, promoting the sustainable development of salt lake resources and their ecological functions.…”
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Trends and future predictions of chronic kidney disease due to diabetes mellitus type 2 attributable to dietary risks: insights based on GBD 2021 data by Ming Xu, Ming Xu, Hongxia Wei, Hongxia Wei, Dongqing Lv, Dongqing Lv, Yanhong Wei, Yanhong Wei, Ziang Liu, Ziang Liu, Yi Zhang, Yi Zhang, Yunfeng Liu, Yunfeng Liu, Yunfeng Liu

“…Throughout this period, both mortality and DALY rates associated with dietary risks increased significantly, with the most rapid increase in diet high in sugar-sweetened beverages, highlighting the considerable impact of dietary factors on the global CKD-T2DM landscape. Geographic disparities in T2DM trends are evident, with the most significant increases in age-standardized mortality rates (ASMR) and age-standardized DALY rates (ASDR) observed in regions such as high-income North America and Central Latin America. …”
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Self-Management Strategies for Low Back Pain Among Horticulture Workers: Protocol for a Type II Hybrid Effectiveness-Implementation Study by Kim Dunleavy, Heidi Liss Radunovich, Jason M Beneciuk, Boyi Hu, Yang Yang, Janeen McCormick Blythe, Kelly K Gurka

“…ObjectiveThis study will (1) investigate the effectiveness of self-management strategies for nursery and landscape workers by comparing within-subject control and intervention periods and (2) determine if adoption and effectiveness differs between participants randomly assigned to review self-management videos only and those who also receive multimodal implementation support. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…This study aims to establish a novel prognostic signature and identify M2-like TAM-related biomarkers in OC using RNAseq-based transcriptome analysis.MethodsPrognostic M2-like TAM-related genes were identified through univariate Cox regression, consensus clustering, and LASSO regression. Immune landscape analysis was conducted to assess immune cell composition and immune checkpoint genes in high- and low-risk groups. …”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Abstract Background Since the emergence of SARS-CoV-2, the causative agent of COVID-19, the global health landscape has confronted an unprecedented and formidable challenge. …”
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A long-term drought reconstruction based on oxygen isotope tree ring data for central and eastern parts of Europe (Romania) by V. Nagavciuc, V. Nagavciuc, G. Helle, M. Rădoane, C.-C. Roibu, M.-G. Cotos, M. Ionita, M. Ionita

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Critical signals for grassland desertification prediction in the transition zone between desert and typical steppe in InnerMongolia, China by Baoping Meng, Zhuoyan Jin, Jin Chen, Yili Kuang, Shuhua Yi, Yanyan Lv, Jinrong Li

“…We analyzed vegetation patch features (including percentage of landscape (PLAND), patch density (PD), largest patch index (LPI), and perimeter-area ratio distribution (PARA)), species diversity indices (Shannon-Wiener, Simpson, Margalef, Pielou), soil seed bank density, similarity index, and established their relations. …”
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Challenges and Opportunities for Data Sharing Related to Artificial Intelligence Tools in Health Care in Low- and Middle-Income Countries: Systematic Review and Case Study From Tha... by Aprajita Kaushik, Capucine Barcellona, Nikita Kanumoory Mandyam, Si Ying Tan, Jasper Tromp

“…Primary research studies, perspectives, policy landscape analyses, and commentaries performed in or involving an LMIC context were included. …”
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Geoconservation in Latin America and the Caribbean by Maria Da Gloria Motta Garcia, Marcos Antonio Leite Do Nascimento

“…In the initial phase, two workshops were conducted in 2023, focusing on the LAC geoconservation landscape and the progress of the Geoheritage Map of South America. …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

“…Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses. …”
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Assessing the Potential of Brewer’s Spent Grain to Enhance Cookie Physicochemical and Nutritional Profiles by Marisa Nicolai, Maria Lídia Palma, Ricardo Reis, Rúben Amaro, Jaime Fernandes, Elsa M. Gonçalves, Mafalda Silva, Manuela Lageiro, Adília Charmier, Elisabete Maurício, Patrícia Branco, Carla Palma, Joaquim Silva, Maria Cristiana Nunes, Pedro C. B. Fernandes, Paula Pereira

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Shaping the Securities Industry Spatial Pattern by Institutional Arrangements in China: An Analysis Based on Headquarters Location of Securities Companies by Zhang Xuchen, Pan Fenghua

“…The evolving regulatory landscape, along with China's unique institutional characteristics, has ensured that the country's securities industry remains highly centralized, with significant financial resources concentrated in key cities. …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…These findings offer novel insights into the surrogate immunomolecular subtyping landscape of DCIS, potentially refining risk stratification and therapeutic approaches. …”
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