From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…This review summarizes the application strategies and delivery methods of CRISPR/Cas, discusses recent progress in CRISPR/Cas-based disease models and therapies, and provides an overview of the landscape of clinical trials. Current obstacles and future directions regarding the bench-to-bedside transition are also discussed.…”
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Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. The resulting models revealed many statistically significant associations, although their predictive powers were overall weak. …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…The Gene Set Variation Analysis was performed for functional annotation. The immune landscape analysis, including immune checkpoint gene analysis, single sample gene set enrichment analysis, tumor immune dysfunction and exclusion (TIDE) analysis, immune infiltration cell, and tumor mutation burden analysis (TMB), was conducted. …”
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Patterns of interpopulation variation and physiological trade-offs of the acute thermal tolerance of juvenile Chinook salmon (Oncorhynchus tshawytscha) by Kenneth W. Zillig, Kenneth W. Zillig, Heather N. Bell, Alyssa M. FitzGerald, Alyssa M. FitzGerald, Nann A. Fangue

“…Associations between ΔCTM, acclimation capacity, and source population environmental characteristics were also examined using data from a landscape-scale, regional, river temperature model.ResultsFish acclimated to 16°C or 20°C exhibited heat hardening (positive ΔCTM), while those acclimated to 11°C exhibited “heat weakening” (negative ΔCTM), a rare phenomenon in the literature. …”
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Spatial and social relevance perceptions by pre-service teachers of learning about oil palm management as a local or nonlocal socioscientific issue by Finn Kristen Matthiesen, Gina Nolte, Finn Rehling, I Gede Arjana, Lola Utama Sitompul, Upik Yelianti, Susanne Bögeholz, Susanne Bögeholz

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Modelling GNSS-observed seasonal velocity changes of the Ross Ice Shelf, Antarctica, using the Ice-sheet and Sea-level System Model (ISSM) by F. Baldacchino, F. Baldacchino, N. R. Golledge, M. Morlighem, H. Horgan, H. Horgan, H. Horgan, A. V. Alevropoulos-Borrill, A. Malyarenko, A. Malyarenko, A. Gossart, D. P. Lowry, L. van Haastrecht

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Health recommender systems to facilitate collaborative decision-making in chronic disease management: A scoping review by Antonia Barbaric, Kenneth Christofferson, Susanne M Benseler, Chitra Lalloo, Alex Mariakakis, Quynh Pham, Joost F Swart, Rae S M Yeung, Joseph A Cafazzo

“…Lay summary Our work aims to provide a summary of the current landscape of health recommender system (HRS) use for chronic disease management. …”
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Rotonda Mihail Sebastian (MLR, 1975) 30 de ani de la moarte by Lucian Chișu

“…We had therefore a panoramic image of our literary landscape which lacked, due to a subtle ablution of memory, the ideological component, perfectly substituted by aesthetic arguments of expressivity or the art of the word. …”
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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…‘Cardiovascular outcome’ and ‘diabetic kidney diseases’ were identified as keywords in their burst period over the past three years.Conclusion Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. …”
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Governance of Indigenous data in open earth systems science by Lydia Jennings, Katherine Jones, Riley Taitingfong, Andrew Martinez, Dominique David-Chavez, Rosanna ʻAnolani Alegado, Adrien Tofighi-Niaki, Julie Maldonado, Bill Thomas, Dennis Dye, Jeff Weber, Katie V. Spellman, Scott Ketchum, Ruth Duerr, Noor Johnson, Jennifer Balch, Stephanie Russo Carroll

“…The Earth Data Relations Working Group (EDRWG), convened to address this question and envision a research landscape that acknowledges the legacy of extractive practices and embraces new norms across Earth science institutions and open science research. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Systematic underestimation of type-specific ecosystem process variability in the Community Land Model v5 over Europe by C. Poppe Terán, C. Poppe Terán, C. Poppe Terán, B. S. Naz, B. S. Naz, H. Vereecken, H. Vereecken, R. Baatz, R. A. Fisher, H.-J. Hendricks Franssen, H.-J. Hendricks Franssen

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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Meta-synthesizing of Practices of Corporate Social Responsibility: External Stake-holders Approach by Maryam Khalatbari Moazam, Hamidreza Yazdani, Naser Asgari

“…The critical importance of CSR in the competitive landscape of today's markets has led to a proliferation of scholarly studies from varied perspectives, each with distinct objectives. …”
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Functionality of bacterial communities in constructed wetlands used for water purification: influence of root components and seasonality by Yao Huang, Yao Huang, Weili An, Weili An, Tianzhu Ning, Zhiguang Ma, Yuelin Li, Ke Liu, Lingbo Ji, Lingbo Ji, Hongxiao Liu, Dafeng Hui, Hai Ren

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A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research by Sun Young Lee, Mikael Klingeborn, Jeff W. M. Bulte, Daniel T. Chiu, Michael Chopp, Christopher W. Cutler, Saumya Das, Charles E. Egwuagu, Christie D. Fowler, Sarah F. Hamm‐Alvarez, Hakho Lee, Yutao Liu, Ben Mead, Tara L. Moore, Sriram Ravindran, Ashok K. Shetty, Johan Skog, Kenneth W. Witwer, Ali R. Djalilian, Alissa M. Weaver

“…This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases.…”
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Examine the impact of green-synthesized nanomaterials on the germination rates and seedling characteristics of African Marigold (Tagetes erecta L. var. Pusa Narangi Ganda and Pusa... by Kunal Adhikary, Tapas Mondal, Jayoti Majumder, Tapas Kumar Chowdhuri, Subhra Mukherjee, Karishma Maherukh

“…Materials and methods: This study was conducted at ICAR-AICRP on Floriculture and Landscape Architecture, HRS, Mandouri, Bidhan Chandra Krishi Vishwavidyalaya, West Bengal, India. …”
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Experimental inconsistencies undermine accurate characterization of microplastics and identification of environmental drivers:a metadata analysis in Chinese aquatic environment by Qinwei Chen, Peng Wang, Ru Liu, Mingjun Ding, Hua Zhang, Gaoxiang Huang, Minghua Nie

“…The abundance of microplastics was found to be significantly influenced by both human activities and natural processes, including farmland areas, landscape connectivity and annual mean precipitation. …”
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Ecological networks construction and optimization in the Longdong Loess Plateau: The advantages of self-organizing map and complex networks by Xueyu Huang, Lina Xiu, Zhixiang Lu, Jiahui Wang

“…The additional corridors also serve as an important reference for enhancing regional landscape connectivity and ecological security.…”
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Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review by Alice Burnand, Abi Woodward, Vladimir Kolodin, Jill Manthorpe, Yogini Jani, Mine Orlu, Cini Bhanu, Kritika Samsi, Victoria Vickerstaff, Jane Wilcock, Jane Ward, Greta Rait, Nathan Davies

“…Searches included literature exploring the landscape of clinical pharmacy services for older people in the UK, focusing on roles and services delivered, perceptions, and experiences. …”
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