Outcomes of oncologic arthroplasty in children and adolescents with malignant limb tumors: a systematic review by Vyacheslav I. Zorin, Sergei V. Vissarionov, Alexandr Y. Makarov, Timofey S. Rybinskikh, Kristina N. Rodionova

“…However, the development and refinement of chemotherapy and radiotherapy protocols, along with advances in surgical techniques and implants, have significantly altered the treatment landscape for these patients. Currently, limb-sparing oncologic arthroplasty is the preferred surgical approach for treating limb sarcomas in children. …”
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Hospital antimicrobial stewardship funding and resourcing impact on broad-spectrum antibiotic use: a cross-sectional study by Megan Tu, Zong Heng Shi, Valerie Leung, Kevin A Brown, Kevin L Schwartz, Nick Daneman, Bradley J Langford

“…Methods: We conducted a cross-sectional study of antimicrobial use (AMU) across 63 Ontario hospitals from April 2020 to March 2023. The Ontario ASP Landscape Survey provided data on ASP resourcing and antibiotic utilization. …”
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Antimicrobial resistance, virulence gene profiles, and molecular epidemiology of enterococcal isolates from patients with urinary tract infections in Shanghai, China by Weiyi Wu, Shuzhen Xiao, Lizhong Han, Qiong Wu

“…The prevalence of E. faecalis CC16 and E. faecium CC17 further complicates the treatment landscape for Enterococcal UTIs.IMPORTANCEThis study highlighted the critical need to understand Enterococcal strains causing UTIs in Shanghai, given their high prevalence. …”
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Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury by Dandan Mao, Qi Chen, Shuolan Tong, Zixia Xu, Guofeng Yu, Chuan Chang, Yao Lv

“…Additionally, relying on the immune infiltration landscape associated with cuproptosis, we carried out immune cell correlation analysis on hub genes. …”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…Methods Relationships between SOX10 and immune landscape were estimated using bioinformatic approaches. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…Our findings underscore the importance of analyzing NSCLC histological subtypes separately when investigating the spatial immune landscape, as microenvironmental characteristics and cellular interactions differed by subtype. …”
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Digital interactive experience- and game-based fall interventions for community-dwelling healthy older adults: a cross-disciplinary systematic review by Celina Ciemer, Celina Ciemer, Lisa Kröper, Thomas Jürgen Klotzbier, Sabiha Ghellal, Nadja Schott

“…Digital, interactive interventions, incorporating experience-, and game-related aspects, offer a promising solution, making this topic inherently cross-disciplinary.ObjectiveThis review aims to assess the current landscape of digital interactive experience and game-based fall interventions for community-dwelling, healthy older adults. …”
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Direct and indirect effects of land use on microbiomes of trap-nesting solitary bee larvae and nests by Birte Peters, Birte Peters, Birte Peters, Sara Diana Leonhardt, Michael Schloter, Alexander Keller

“…However, the drivers and dynamics of healthy microbiome in solitary bees are still poorly understood, especially regarding the direct and indirect effects of land use on the diversity and composition of these microbial communities.MethodsWe examined bacterial communities in the offspring and nest materials of the Megachilid trap-nesting solitary bee, Osmia bicornis, along a gradient of land use intensification by 16S rRNA gene metabarcoding. Given that landscape composition, climatic conditions, and food resources are known to influence microbial compositions in solitary bee species, we hypothesized that land use changes would alter resources available for food and nest material collection and thereby affecting the microbiomes in offspring and their nest environments. …”
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Synthetic peptides as valuable and versatile tools for research: our 20 year journey in Chile by Constanza Cárdenas, Paula Santana, Claudio Álvarez, Luis Mercado, Sergio Marshall, Fernando Albericio, Fanny Guzmán

“…In this report, we provide an overview of the extensive application landscape of synthetic peptides, presenting examples developed in-house across different areas which include a summary of the methodologies and results obtained.…”
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Assessing Four Decades of Land Use and Land Cover Change: Policy Impacts and Environmental Dynamics in the Min River Basin, Fujian, China by Weixuan Huang, Anil Shrestha, Yifan Xie, Jianwu Yan, Jingxin Wang, Futao Guo, Yuee Cao, Guangyu Wang

“…First, we mapped and quantified changes (i.e., LULCC and landscape indices) in forests, croplands, urban areas, and water bodies from 1980 to 2020 using the China National Land Use/Cover Change (CNLUCC) and ArcGIS Pro 2.3. …”
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Sensor-controlled fertigation management for higher yield and quality in greenhouse hydroponic strawberries by George Kerrigan Hutchinson, Lan Xuan Nguyen, Zilfina Rubio Ames, Krishna Nemali, Rhuanito Soranz Ferrarezi

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Historical and projected forest cover changes in the Mount Kenya Ecosystem: Implications for sustainable forest management by Brian Rotich, Abdalrahman Ahmed, Benjamin Kinyili, Harison Kipkulei

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Predictive Policing and Enhancing Security Performance through Artificial Intelligence Applications by Bensalem Kheira

“… The digital transformation era has revolutionized the global landscape, urging countries to modernize their infrastructures to integrate artificial intelligence (AI) applications effectively. …”
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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…These findings both reinforce our current understanding of prostate cancer’s molecular landscape and point to unexplored pathways that could lead to novel therapeutic strategies. …”
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Navigating Patient Satisfaction: A Qualitative Insight into Healthcare Delivery during the COVID-19 Pandemic by Shazina Saeed, Manmohan Singhal, Mohd Shannawaz, Mandeep Kumar Arora

“…Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has significantly impacted healthcare delivery systems worldwide, necessitating a re-evaluation of patient satisfaction metrics and experiences within this altered landscape. These changes, while ensuring continuity of care, posed unique challenges, including accessibility, technological adaptation and the maintenance of the quality of patient interactions. …”
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The Association Between COVID-19 Vaccination Uptake and Information-Seeking Behaviors Using the Internet: Nationwide Cross-Sectional Study by Kazuya Taira, Misa Shiomi, Takayo Nakabe, Yuichi Imanaka

“…This research sheds light on how the digital information landscape influences health behaviors, stressing the importance of accurate and trustworthy health information amidst global health emergencies.…”
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Mitigation of environmental impacts in ornamental rock and limestone aggregate quarries in arid and semi-arid areas by M.A. Peñaranda Barba, V. Alarcón Martínez, I. Gómez Lucas, J. Navarro Pedreño

“…All of this has given rise to numerous active and abandoned mines, where no restoration process has been carried out, generating strong impacts on the environment.METHODS: In this study, 8 environmental impact assessments studies of ornamental rock and aggregate quarries in the Region of Murcia were analysed to identify the negative impacts on the abiotic and biotic environment, landscape, socio-economic and socio-cultural environment, and infrastructures and analysing preventive and control measures. …”
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Heat shock transcription factor 1 facilitates liver cancer progression by driving super‐enhancer‐mediated transcription of MYCN by Yizhe Liu, Qili Shi, Yue Su, Zhiao Chen, Xianghuo He

“…Additionally, we utilized CUT&Tag, H3K27 acetylation enrichment, and RNA sequencing (RNA‐seq) to investigate the super‐enhancer (SE) regulatory landscapes of HSF1 in liver cancer cell lines. Results HSF1 expression is elevated in HCC and is linked to poor prognosis in several datasets. …”
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Pathological variants in HPV-independent vulvar tumours by Sanja A. Farkas, Alvida Qvick, Gisela Helenius, Gabriella Lillsunde-Larsson

“…The mutational frequencies and landscape for HPV-associated and HPV-independent vulvar tumor development are supposedly two distinctly different pathways and more detailed knowledge on target biological mechanisms for individualized future treatments is needed. …”
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The Mediating Role of Cognitive Reappraisal on Bedtime Procrastination and Sleep Quality in Higher Educational Context: A Three-Wave Longitudinal Study by Zhang Y, Rehman S, Addas A, Ahmad M, Khan A

“…Yuan Zhang,1 Shazia Rehman,2 Abdullah Addas,3,4 Mehmood Ahmad,5 Ayesha Khan6 1College of Art, Nanyang Vocational College of Agriculture, Nan Yang, Henan, 47300, People’s Republic of China; 2Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China; 3Department of Civil Engineering, College of Engineering, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia; 4Landscape Architecture Department, Faculty of Architecture and Planning, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan; 6Department of Applied Psychology, Faculty of Social Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, PakistanCorrespondence: Shazia Rehman, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-13308429613, Email rehmanshazia.malik@gmail.comBackground: While bedtime procrastination is commonly associated with adverse outcomes such as poor sleep quality, the mechanisms mediating these effects remain underexplored. …”
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