Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

“…The goal of this work is to provide a systematic understanding of the current research landscape and of future directions for WT1-related studies.…”
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Perception and adaptation to climate change of the K'Ho people related to coffee production in Lâm Đồng province, Vietnam by Nguyen Dinh Nghiep, Le Minh Chien, Nguyen Van Hoang, Pham Hong Hai, Dao Thi Hieu, Nguyen Thi Thanh Thuan, Do Van Toan, Le Quang Ngoc, Ho Dieu Huyen

“…The K'Ho people recognize substantial changes due to climate change and therefore have various levels of adaptation to continue developing coffee cultivation, including plant level, coffee garden level, landscape level, and household level. Additionally, they have implemented several pest management strategies on coffee plants, such as pesticide spraying, regular pest monitoring, and manual methods (leaf plucking, hand-picking pests). …”
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Deciphering of emergency construction objects using satellite imagery and sub-satellite monitoring data in the Arctic by M. L. Kazaryan, A. A. Richter, M. A. Shakhramanyan, S. M. Grigoriev

“…The research is carried out on the basis of satellite images of high spatial resolution, depicting territories with different lighting conditions, landscape and component composition of the Arctic surface. …”
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Genomic epidemiology of invasive Group A Streptococcus infections in Argentina, 2023: high prevalence of emm1-global and detection of emm1 hypervirulent lineages by Lucía Cipolla, Ariel Gianecini, Tomas Poklepovich, Paula Etcheverry, Florencia Rocca, Mónica Prieto

“…This seminal study provides initial insights into the genomic landscape of iGAS, contributing to active surveillance to monitor emerging virulent emm1 lineages and cross-border transmission in South America.IMPORTANCEAmid the increase in invasive Streptococcus pyogenes infections in Argentina in 2023, the implementation of genomic analysis of isolates allowed us to detect at the national level the prevalence of the emm1 type and within the M1 type, emerging national and international hypervirulent lineages. …”
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Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…Additionally, the interactions between ncRNA-derived peptides and EVs provide a mechanism for the enhanced surface presentation of these peptides and highlight a novel pathway for their systemic distribution, potentially altering immune surveillance and therapeutic landscapes.…”
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Capable design or designing capabilities? An exploration of service design as an emerging organizational capability in Telenor – Martinkenaite by Ieva Martinkenaite, Karl Joachim Breunig, Annita Fjuk

“…Service design has become an established business practice of how firms create new products and services to promote differentiation in an increasingly uncertain business landscape. Implicit in the literature on service design are assumptions about strategic implications of adopting the prescribed innovation methods and tools. …”
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Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans by Fengqing Shao, Xiaoqi Liu, Xianzhi Zhang, Qi Wang, Wencai Wang

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Evaluating Producer Welfare Benefits of Whole-Farm Revenue Insurance by Moharram Ainollahi Ahmadabadi, Mohammad Ghahremanzadeh, Ghader Dashti, Seyed-Ali Hosseini-Yekani

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Optimizing ultra high-performance concrete (UHPC) mix proportions using technique for order preference by similarity to ideal solution (TOPSIS) for enhanced performance: Precision... by Sathya Sai Regalla, N. Senthil Kumar

“…In essence, TOPSIS transforms a complex, multi-faceted decision landscape into a more accessible, data-driven process, promoting optimized UHPC design for advanced structural performance. …”
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Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein by Ziyuan Niu, Georgios Kementzidis, Miriam Rafailovich, Marcia Simon, Evangelos Papadopoulos, Bertal H. Aktas, Yuefan Deng

“…This effect is primarily pH-driven at extreme acidity and thermo-driven at moderate pH. 3) The Gibbs free energy landscape reveals that pH as the main driver of structural changes. 4) The parametrized methods enable the predictions of the S-protein properties at any reasonable pH and thermal conditions without explicit MD simulations.…”
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Exploring LLMs Applications in Law: A Literature Review on Current Legal NLP Approaches by Marco Siino, Mariana Falco, Daniele Croce, Paolo Rosso

“…Artificial Intelligence (AI) is reshaping the legal landscape, with software tools now impacting various aspects of legal work. …”
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Immunotherapy versus targeted therapy in management of recurrent squamous cell carcinoma of oral tongue by Nadimul Hoda, Aastha Moza, K.P. Amith, K.S. Sabitha

“…Background: Targeted therapies, and more recently immunotherapy, have dramatically changed the landscape of treatments in oral cavity cancers and improved clinical outcomes. …”
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Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review by Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang

“…The analysis focused on three primary areas: (1) the current regulatory landscape, (2) technological advancements and challenges, and (3) economic and commercial factors influencing DTx adoption in Korea. …”
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Leveraging Next-Generation Sequencing Application from Identity to Purity Profiling of Nucleic Acid-Based Products by Rucha Wadapurkar, Swarda Deo, Renuka Khanzode, Ajay Singh

“…They represent an emerging field; thus, their quality control and regulatory landscape is evolving to ensure adequate quality and safety. …”
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Spatial Analysis and Socio-Environmental Determinants of Canine Visceral Leishmaniasis in an Urban Area in Northeastern Brazil by Natan Diego Alves de Freitas, Lucas José Macedo Freire, Suely Ruth Silva, Nilton Guedes do Nascimento, Pedro Cordeiro-Estrela

“…The urbanization process has led to significant changes in the landscape, shifting the epidemiological profile of the visceral leishmaniasis (VL) in Brazil. …”
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Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol by Grace Lu-Yao, Jennifer M Johnson, Amy L Shaver, Nikita Nikita, Swapnil Sharma, Daniel S Lefler, Atrayee Basu-Mallick, Meghan L Butryn

“…Introduction Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple cancer types. Sex plays an important role in both the development of cancer as well as the functioning of the immune system. …”
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Imperatives of Strengthening Governance in the World Bank’s Engagement in Iraq, 2014–2018 by A. I. Solomatin

“…The Arab Awakening became a watershed event for the states of the Middle East and North Africa (MENA) and changing the political landscape of the entire region. The crisis in the Arab world provoked an unprecedented strengthening of the Salafi jihadist groups, in particular, the notorious Islamic State in Iraq and al-Sham (ISIS). …”
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The impact of life events and transitions on physical activity: A scoping review. by Hannes Gropper, Jannika M John, Gorden Sudeck, Ansgar Thiel

“…It also shows that the research landscape is characterized by a lack of conceptual clarity and by disparate methodologies, making it difficult to synthesize results across studies.…”
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Monitoring and management of adverse effects associated with trastuzumab deruxtecan: a UAE-specific consensus by Emad Dawoud, Fathi Azribi, Aref Chehal, Shaheenah Dawood, Syed Hammad Tirmazy, Dina Hamza, Hassan Jaafar, Hussam Marashi

“…Although early diagnosis contributes to favorable prognoses, novel treatment modalities like antibody-drug conjugates (ADCs) have significantly broadened the therapeutic landscape for patients in metastatic settings. The recognition of “HER2-low” expression as a targetable category has caused a paradigm shift in the management of breast cancer. …”
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Impacts of Livestock Grazing on Wild Ungulate Habitat in the Khata Corridor, Bardiya, Nepal by Usha Dahal, Nirjala Raut, Anubhav Dhital, Suruchi Mainali, Deepak Gautam, Shankar Tripathi

“…We recommend the development of comprehensive wildlife livestock grazing strategies for planning sustainable livestock farming and for important wildlife areas to maintain long-term landscape connectivity to protect migrating endangered wild species.…”
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