Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report by Hebatullah Abdulazeem, Israel Júnior Borges do Nascimento, Ishanka Weerasekara, Amin Sharifan, Victor Grandi Bianco, Ciara Cunningham, Indunil Kularathne, Genevieve Deeken, Jerome de Barros, Brijesh Sathian, Lasse Østengaard, Frederique Lamontagne-Godwin, Joost van Hoof, Ledia Lazeri, Cassie Redlich, Hannah R Marston, Ryan Alistair Dos Santos, Natasha Azzopardi-Muscat, Yongjie Yon, David Novillo-Ortiz

“…In addition, our study aimed to map the current landscape of global research initiatives on DHTs on the prevention, diagnosis, treatment, and support of people living with dementia and their caregivers. …”
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Genomic insights into genetic diversity and seed coat color change in common bean composite populations by Eva Plestenjak, Eva Plestenjak, Mohamed Neji, Lovro Sinkovič, Vladimir Meglič, Barbara Pipan

“…The strong genetic differentiation between standard varieties and composite populations highlights the role of selective breeding in shaping the genetic landscape of common bean. The results suggest that variation in seed coat color is controlled by both regulatory and structural genetic changes, providing valuable information for breeding programs.ConclusionThis study provides a detailed analysis of the genetic architecture of seed coat color variation in common bean. …”
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Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…Some portions of large ancient buildings are still visible within the landscape today (the Mars Gate, cryptoporticus, and bathhouses). …”
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L’enterrement d’une triade divine féminine à Lugdunum : étude du dépôt de la place d’Albon à Lyon (Métropole de Lyon) by Lucas Guillaud, Emmanuel Bernot, Aline Colombier-Gougouzian, Amaury Gilles, Nicolas Garnier

“…It was sealed with a large marble slab and marked in the landscape by a tile placed on edge on the wall of the horreum.The collection comprises a large bronze vessel that serves as a container for other objects. …”
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New era towards autonomous additive manufacturing: a review of recent trends and future perspectives by Haolin Fan, Chenshu Liu, Shijie Bian, Changyu Ma, Junlin Huang, Xuan Liu, Marshall Doyle, Thomas Lu, Edward Chow, Lianyi Chen, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…The additive manufacturing (AM) landscape has significantly transformed in alignment with Industry 4.0 principles, primarily driven by the integration of artificial intelligence (AI) and digital twins (DT). …”
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A comprehensive environmental index for monitoring ecological quality of typical alpine wetlands in Central Asia by Jiudan Zhang, Junli Li, Changming Zhu, Anming Bao, Amaury Frankl, Philippe De Maeyer, Tim Van de Voorde

“…Meanwhile, improvements were also observed in hydrological conditions, vegetation vitality, and aboveground biomass, coupled with a reduction in wetland landscape fragmentation, improving ecological stability. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Conclusion This study elucidates the complex cellular landscape and immune microenvironment of PCAS, highlighting potential molecular targets for the development of novel therapies. …”
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A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases by Anthony C. Nichols, Michelle Chan-Seng-Yue, John Yoo, Sumit K. Agrawal, Maud H. W. Starmans, Daryl Waggott, Nicholas J. Harding, Samuel A. Dowthwaite, David A. Palma, Kevin Fung, Bret Wehrli, S. Danielle MacNeil, Philippe Lambin, Eric Winquist, James Koropatnick, Joe S. Mymryk, Paul C. Boutros, John W. Barrett

“…Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.…”
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Spatio-temporal dynamics of speleothem growth and glaciation in the British Isles by S. Panitz, S. Panitz, M. Rogerson, J. Longman, N. Scroxton, T. J. Lawson, T. C. Atkinson, V. Ersek, J. Baldini, L. Baldini, S. Umbo, M. A. Lone, G. M. Henderson, S. F. M. Breitenbach

“…Further study of leads and lags in speleothem growth compared to surface deposition may provide new insights into landscape-scale dynamics during ice sheet growth and retreat.…”
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Uncovering the whole genome silencers of human cells via Ss-STARR-seq by Xiusheng Zhu, Lei Huang, Chao Wang, Guoli Li, Biao Deng, Dashuai Kong, Xiaoxiao Wang, Rongrong Chang, Yi Gu, Qiuhan Wen, Siyuan Kong, Yuwen Liu, Yubo Zhang

“…In summary, this study pioneers the elucidation of the genome-wide silencer landscape in human cells, delineates their global regulatory features, and identifies specific silencers influencing cancer cell proliferation.…”
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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…By advancing our understanding of the clinical and molecular landscape of early-onset breast cancer and very early-onset breast cancer, this study lays the groundwork for improving outcomes in these underserved patients through tailored therapeutic approaches.…”
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Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer by Riqing Huang, Anqi Hu, Qixiang Rong, Ditian Shu, Meiting Chen, Wei Yang, Yue Zhang, Qiufan Zheng, Xin An, Cong Xue, Haifeng Li, Yanxia Shi

“…Abstract Background HER2-targeted antibody–drug conjugates (ADCs) have revolutionized the treatment landscape of metastatic breast cancer. However, the efficacy of these therapies may be compromised by genomic alterations. …”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

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Research Progress in and Planning Strategies for Multi-scale Measurement of the Efficiency of Urban Blue-Green Infrastructure in Carbon Sink Enhancement and Emission Reduction by Song LIU, Zhaocheng BAI, Dizi LIU, Peiyu SHEN

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Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease by Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei

“…Conclusions Our research suggests that scRNA-seq can reflect the multifaceted mitochondrial landscape of DKD renal tubular cells after drug treatment, and these findings may provide new targets for DKD therapy at the organelle level.…”
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Spatiotemporal analysis of Plasmodium falciparum erythrocyte binding antigen-175 gene dimorphism in Ghana by Abraham Y. Kpirikai, Belinda A. Ofosu, Josie N. A. Okai, Victor Kornu, Abdul Rashid Kassim, Esther Donkor, Frederica Malm, Osumanu Ahmed, Mona-Liza E. Sakyi, Samirah Saiid, Albert Yao Kudakpo, Charles Mensah, Francis Dzabeng, Collins Morang’a, Gordon A. Awandare, Yaw Aniweh, Lucas N. Amenga-Etego

“…There is paucity of data on the prevalence of these alleles and their epidemiology in the Ghanaian malaria landscape and hence this study. Methods Parasite gDNA was extracted from archived Dried Blood Spots (DBS) prepared from 700 confirmed malaria-infected individuals and analysed for P. falciparum EBA-175 dimorphism. …”
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Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Single-cell RNA sequencing was performed to elucidate the tumor immune landscape after azvudine treatment. After propensity score matching, 2404 azvudine and 1202 Paxlovid recipients from Henan Province were included. …”
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PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesothelioma by Solange Peters, Urania Dafni, Panagiota Zygoura, Sanjay Popat, Mary O'Brien, Rolf A Stahel, Alessandra Curioni-Fontecedro, Georges Coukos, Amy Roy, Riyaz Shah, Krisztian Homicsko, James Spicer, Stephen P Finn, David Gilligan, Maxim Norkin, Stephanie Tissot, Nicholas Shakarishvili, Anthony Pope, Patricia Fisher, Sylvie Rusakiewicz, Ekaterina Fortis, Nesa Marti, Roswitha Kammler

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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…A suboptimal radiotherapy regimen in combination with muFAP-4-1BBL attained primary tumor control and measurable abscopal effects. Immune TME landscape analyses showed post-treatment increased infiltration of activated immune cells associated with the combined radioimmunotherapy treatment. …”
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Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…Though Reims’ territory is above all marked by traces of its successive enclosures, the road networks, monuments, and habitat installations are no less essential as components of this ancient urban landscape. The domus question has long occupied an important place in the archaeological research of Reims and, with more than thirty years of research and the development of rescue archaeology, our knowledge of these urban houses has been substantially improved. …”
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