Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. The resulting models revealed many statistically significant associations, although their predictive powers were overall weak. …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…The Gene Set Variation Analysis was performed for functional annotation. The immune landscape analysis, including immune checkpoint gene analysis, single sample gene set enrichment analysis, tumor immune dysfunction and exclusion (TIDE) analysis, immune infiltration cell, and tumor mutation burden analysis (TMB), was conducted. …”
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Spatial and social relevance perceptions by pre-service teachers of learning about oil palm management as a local or nonlocal socioscientific issue by Finn Kristen Matthiesen, Gina Nolte, Finn Rehling, I Gede Arjana, Lola Utama Sitompul, Upik Yelianti, Susanne Bögeholz, Susanne Bögeholz

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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…‘Cardiovascular outcome’ and ‘diabetic kidney diseases’ were identified as keywords in their burst period over the past three years.Conclusion Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Systematic underestimation of type-specific ecosystem process variability in the Community Land Model v5 over Europe by C. Poppe Terán, C. Poppe Terán, C. Poppe Terán, B. S. Naz, B. S. Naz, H. Vereecken, H. Vereecken, R. Baatz, R. A. Fisher, H.-J. Hendricks Franssen, H.-J. Hendricks Franssen

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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Meta-synthesizing of Practices of Corporate Social Responsibility: External Stake-holders Approach by Maryam Khalatbari Moazam, Hamidreza Yazdani, Naser Asgari

“…The critical importance of CSR in the competitive landscape of today's markets has led to a proliferation of scholarly studies from varied perspectives, each with distinct objectives. …”
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Functionality of bacterial communities in constructed wetlands used for water purification: influence of root components and seasonality by Yao Huang, Yao Huang, Weili An, Weili An, Tianzhu Ning, Zhiguang Ma, Yuelin Li, Ke Liu, Lingbo Ji, Lingbo Ji, Hongxiao Liu, Dafeng Hui, Hai Ren

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Examine the impact of green-synthesized nanomaterials on the germination rates and seedling characteristics of African Marigold (Tagetes erecta L. var. Pusa Narangi Ganda and Pusa... by Kunal Adhikary, Tapas Mondal, Jayoti Majumder, Tapas Kumar Chowdhuri, Subhra Mukherjee, Karishma Maherukh

“…Materials and methods: This study was conducted at ICAR-AICRP on Floriculture and Landscape Architecture, HRS, Mandouri, Bidhan Chandra Krishi Vishwavidyalaya, West Bengal, India. …”
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Experimental inconsistencies undermine accurate characterization of microplastics and identification of environmental drivers:a metadata analysis in Chinese aquatic environment by Qinwei Chen, Peng Wang, Ru Liu, Mingjun Ding, Hua Zhang, Gaoxiang Huang, Minghua Nie

“…The abundance of microplastics was found to be significantly influenced by both human activities and natural processes, including farmland areas, landscape connectivity and annual mean precipitation. …”
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Ecological networks construction and optimization in the Longdong Loess Plateau: The advantages of self-organizing map and complex networks by Xueyu Huang, Lina Xiu, Zhixiang Lu, Jiahui Wang

“…The additional corridors also serve as an important reference for enhancing regional landscape connectivity and ecological security.…”
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Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review by Alice Burnand, Abi Woodward, Vladimir Kolodin, Jill Manthorpe, Yogini Jani, Mine Orlu, Cini Bhanu, Kritika Samsi, Victoria Vickerstaff, Jane Wilcock, Jane Ward, Greta Rait, Nathan Davies

“…Searches included literature exploring the landscape of clinical pharmacy services for older people in the UK, focusing on roles and services delivered, perceptions, and experiences. …”
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Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…Conclusion The lessons from these case studies include that technical teams can and should engage in Political Economy Analysis (PEA) thinking and strategizing, including being aware of and adaptable to the changing PEA landscape and prepared to take advantage of windows of opportunity, including, but not limited to, those emerging from crisis. …”
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Expert Consensus on the Management of Acute Otitis Media in India: A Delphi Study by Tanu Singhal, Shyam Kukreja, Jaydeep Choudhury, Vijay Yewale, Balasubramanian Sundaram, Jagdish Chinnappa, Suhas Prabhu, Balaji Veeraraghavan, Camilla Rodrigues, Vidya Krishna, Winsley Rose, Samir Bhargava

“…The changing epidemiological landscape in India and growing concerns about antimicrobial resistance underscore the need for evidence-based, updated guidance on management. …”
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Russian business in the context of the growth of cybercrime: changes in economic behavior and protective mechanisms by S. G. Simonov, I. V. Lysenko

“…It is found out how the domestic business has changed its attitude to the security of information and information systems of the company. The sectoral landscape of cybercrimes in the Russian Federation for 2023 is presented. …”
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Heterogeneous occurrence of evergreen broad-leaved forests in East Asia: Evidence from plant fossils by Jiagang Zhao, Shufeng Li, Jian Huang, Wenna Ding, Mengxiao Wu, Tao Su, Alexander Farnsworth, Paul J. Valdes, Linlin Chen, Yaowu Xing, Zhekun Zhou

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Interactive and unimodal relationships between plant biomass, abiotic factors, and plant diversity in global grasslands by Marie Spohn, Sumanta Bagchi, Jonathan D. Bakker, Elizabeth T. Borer, Clinton Carbutt, Jane A. Catford, Christopher R. Dickman, Nico Eisenhauer, Anu Eskelinen, Nicole Hagenah, Yann Hautier, Sally E. Koerner, Kimberly J. Komatsu, Lauri Laanisto, Ylva Lekberg, Jason P. Martina, Holly Martinson, Meelis Pärtel, Pablo L. Peri, Anita C. Risch, Nicholas G. Smith, Carly Stevens, G. F. Ciska Veen, Risto Virtanen, Laura Yahdjian, Alyssa L. Young, Hillary S. Young, Eric W. Seabloom

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Photoreceptor metabolic window unveils eye–body interactions by Shaopeng Yang, Zhuoyao Xin, Weijing Cheng, Pingting Zhong, Riqian Liu, Ziyu Zhu, Lisa Zhuoting Zhu, Xianwen Shang, Shida Chen, Wenyong Huang, Lei Zhang, Wei Wang

“…To translate these insights into a practical tool, we developed an artificial intelligence (AI)-driven photoreceptor metabolic window framework and an accompanying interpreter that comprehensively captures the metabolic landscape of photoreceptor–systemic health linkages and simultaneously predicts 16 multisystem health outcomes beyond established approaches while retaining interpretability. …”
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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…Molecular dynamics simulations over 300 ns confirmed the stability of the Mpro/4896 − 4038 complex of protein-ligand. Free energy landscape mapping and MM/PBSA calculations further substantiated the favorable binding and stability of the complex. …”
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