Tumor mutational burden quantification from targeted gene panels: major advancements and challenges by Sara Gandini, Laura Fancello, Pier Giuseppe Pelicci, Luca Mazzarella

“…This overview on the heterogeneous landscape of panel-based TMB quantification aims at providing a context to discuss common standards and illustrates the strong need of further validation and consolidation studies for the clinical interpretation of panel-based TMB values.…”
Get full text

Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…A little over twenty-five years ago, the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) approved the chimeric antibody rituximab which fundamentally altered the landscape of anti-cancer drugs. While only a few antibodies were approved in the immediate years that followed the rituximab approval, the last decade saw a wave of antibody-drug approvals in the oncology arena. …”
Get full text

Exploring the effects of ecological parameters on the spatial structure of genetic tree sequences by Ianni-Ravn, Mariadaria K., Petr, Martin, Racimo, Fernando

“…Our results showcase the potential for linking phylogeography, population genetics and ecology, in order to answer fundamental questions about the nature of spatial interactions across a landscape.…”
Get full text

Multitasking: does task-switching add to the effect of dual-tasking on everyday-like driving behavior? by Piesie A. G. Asuako, Robert Stojan, Otmar Bock, Melanie Mack, Claudia Voelcker-Rehage

“…Forty-five young adults aged 18 to 30 years (age: 23.62 ± 2.51, 28 females) were instructed to follow a lead car driving at a constant speed of 70 km/h through a rural landscape while concurrently performing additional tasks. …”
Get full text

Digging for clues: Stick tools used for honey digging in a second community of ‘forest fragment chimpanzees’ outside the Budongo and Bugoma Forests, Uganda by Matthew R. McLennan, Georgia A. Lorenti, Simon Mugenyi, Jonan Muganzi, Jacqueline Rohen

“…Previously, it was unclear if this technology was unique to the Bulindi community among chimpanzee communities within the greater Budongo–Bugoma landscape. Here, we show that honey digging with sticks occurs in a second group of ‘forest fragment chimpanzees’ (known as the Mairirwe community) that also range outside the Budongo and Bugoma forests. …”
Get full text

Military security in the Arctic: New threats to Russia by V. N. Konyshev, A. A. Sergunin

“…In recent years, the military and political landscape in the Arctic has changed significantly. …”
Get full text

Public Understanding and Expectations of Digital Health Evidence Generation: Focus Group Study by Paulina Bondaronek, Jingfeng Li, Henry W W Potts

“…These perspectives should guide developers, regulators, and policy makers as they balance how to achieve innovation, safety, and public trust in the digital health landscape. Engaging the public in evidence-generation processes and ensuring transparency in app functionality and testing can bridge the gap between public expectations and regulatory standards, fostering trust in digital health technologies.…”
Get full text

Risk Assessment of Non-Point Source Pollution Based on the Minimum Cumulative Resistance Model: A Case Study of Shenyang, China by Yongxin Wang, Jianmin Qiao, Yuanman Hu, Qian Zhang, Xiulin Han, Chunlin Li

“…Therefore, based on the theory of “source–sink” in landscape ecology, combined with the minimum cumulative resistance (MCR) model, this study considered the influence of geographic-environment factors in Shenyang’s built-up area on pollutants in the process of entering the water body under the action of surface runoff, and evaluated its risk. …”
Get full text

Identification of an Autophagy-Related Signature Based on Whole Bone Marrow Sequencing for the Prognosis and Immune Microenvironment Characterization of Multiple Myeloma by Licheng Li, Ting Chen, Jishi Wang, Mengxing Li, Qinshan Li

“…Therefore, a prognostic model for MM was established via a comprehensive analysis of ARGs, through using the clinical models; we have further revealed the molecular landscape features of multiple myeloma.…”
Get full text

Human-Gorilla and Gorilla-Human: Dynamics of Human-animal boundaries and interethnic relationships in the central African rainforest by Takanori Oishi

“…Ambivalent representations of dzil-elizaliza also seem to reflect variation of Bakwele’s self-image.Thus, Bakwele and gorillas can be said to share common properties which circulate across a human-nature landscape in the form of a human-animal hybrid. Local narratives of the human–gorilla demonstrate that gorillas are not only the subject of cultural construction that reflects specific people’s sociocultural conditions, but that they are also actors that sometimes intervene in actual social relationships. …”
Get full text

Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Therefore, to develop innovative therapeutic strategies, research for compounds able to modulate the complex epigenetic landscape of cancer is rapidly surging. Dietary phytochemicals, mostly flavonoids but also tetraterpenoids, organosulfur compounds, and isothiocyanates, represent biologically active molecules found in vegetables, fruits, medicinal plants, and beverages. …”
Get full text

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

“…The goal of this work is to provide a systematic understanding of the current research landscape and of future directions for WT1-related studies.…”
Get full text

Perception and adaptation to climate change of the K'Ho people related to coffee production in Lâm Đồng province, Vietnam by Nguyen Dinh Nghiep, Le Minh Chien, Nguyen Van Hoang, Pham Hong Hai, Dao Thi Hieu, Nguyen Thi Thanh Thuan, Do Van Toan, Le Quang Ngoc, Ho Dieu Huyen

“…The K'Ho people recognize substantial changes due to climate change and therefore have various levels of adaptation to continue developing coffee cultivation, including plant level, coffee garden level, landscape level, and household level. Additionally, they have implemented several pest management strategies on coffee plants, such as pesticide spraying, regular pest monitoring, and manual methods (leaf plucking, hand-picking pests). …”
Get full text

Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response by Arpita Balakrishnan, Arpita Balakrishnan, Gabriela Winiarek, Olga Hołówka, Jakub Godlewski, Agnieszka Bronisz

“…Additionally, the interactions between ncRNA-derived peptides and EVs provide a mechanism for the enhanced surface presentation of these peptides and highlight a novel pathway for their systemic distribution, potentially altering immune surveillance and therapeutic landscapes.…”
Get full text

Capable design or designing capabilities? An exploration of service design as an emerging organizational capability in Telenor – Martinkenaite by Ieva Martinkenaite, Karl Joachim Breunig, Annita Fjuk

“…Service design has become an established business practice of how firms create new products and services to promote differentiation in an increasingly uncertain business landscape. Implicit in the literature on service design are assumptions about strategic implications of adopting the prescribed innovation methods and tools. …”
Get full text

Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans by Fengqing Shao, Xiaoqi Liu, Xianzhi Zhang, Qi Wang, Wencai Wang

Get full text

Evaluating Producer Welfare Benefits of Whole-Farm Revenue Insurance by Moharram Ainollahi Ahmadabadi, Mohammad Ghahremanzadeh, Ghader Dashti, Seyed-Ali Hosseini-Yekani

Get full text

Simulations of pH and thermal effects on SARS-CoV-2 spike glycoprotein by Ziyuan Niu, Georgios Kementzidis, Miriam Rafailovich, Marcia Simon, Evangelos Papadopoulos, Bertal H. Aktas, Yuefan Deng

“…This effect is primarily pH-driven at extreme acidity and thermo-driven at moderate pH. 3) The Gibbs free energy landscape reveals that pH as the main driver of structural changes. 4) The parametrized methods enable the predictions of the S-protein properties at any reasonable pH and thermal conditions without explicit MD simulations.…”
Get full text

Exploring LLMs Applications in Law: A Literature Review on Current Legal NLP Approaches by Marco Siino, Mariana Falco, Daniele Croce, Paolo Rosso

“…Artificial Intelligence (AI) is reshaping the legal landscape, with software tools now impacting various aspects of legal work. …”
Get full text

Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review by Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang

“…The analysis focused on three primary areas: (1) the current regulatory landscape, (2) technological advancements and challenges, and (3) economic and commercial factors influencing DTx adoption in Korea. …”
Get full text