Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study by Mohamed Aseafan, Ali H. Alfakeeh, Emad Tashkandi, Mervat Mahrous, Mohammed Alghamdi, Bader Alshamsan, Marwan Al-Hajeili, Safwan Bakhsh, Kanan Alshammari, Fahad A. Almugbel, Abdulhameed H. Alfagih, Ahmed Allehebi, Mohamed Montaser, Mohamed Hamdy Elsafty, Khaled Abd Elaziz Elnaghi, Ibrahim Issa, Eesa Bakshi, Sadeem AlSubaie, Bandar AlMutairi, Hoda Mokhtar, Mohamed Aboelatta, Nedal Bukhari, Ali M. Alzahrani, Tusneem Elhassan, Ali Alqahtani, Shouki Bazarbashi

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Physicochemical and functional optimization of probiotic yogurt with encapsulated Lacticaseibacillus paracasei E1 enriched with green tea using Box–Behnken design by Muhaimin Rifa'i, Mochammad Fitri Atho'illah, Siti Nur Arifah, Aditya Ragil Suharto, Aghnia Nuri Fadhilla, Nur Alfi Maghfirotus Sa'adah, Esha Ardiansyah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Shinta Oktya Wardhani, Wisnu Barlianto, Hideo Tsuboi, Yoga Dwi Jatmiko

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Spatiotemporal characteristics of macroinvertebrate functional feeding groups and biological assessment of water quality in the Hulan River Basin by Peilun Li, Shuhan Xiong, Jiacheng Liu, Xiangsheng Meng, Anqi Wang, Chunfeng Wang, Yanshen Zhang, Jilong Wang

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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment by Kai Zhang, Xiaoxia Liu, Siyu Huang, Xinrui Liu, Meiqi Zhao, Chao Xue, Shijun Xia, Jianzeng Dong, Yu Kong, Changsheng Ma

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The Effect of Heat-treated Poultry Pellets and Composted Poultry Litter on E. coli Survival in Southeastern US Soils: Florida and Georgia by Karuna Kharel, Cameron A. Bardsley, Charles Bency Appolon, Laurel L. Dunn, Govindaraj Dev Kumar, Krishna Prabha, Manan Sharma, Michelle D. Danyluk, Keith R. Schneider

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Hubungan Konsumsi Makanan Fungsional Sumber Antioksidan dengan Fungsi Kognitif dan Kadar 4-Hydroxynonenal (4-HNE) Plasma Lansia by Widia Rahmawati, Nur Indrawati Lipoeto, Yuliarni Syafrit Syafrita

“…</em><em>Functional foods sources of antioxidant consumption </em><em>were </em><em>obtained </em><em>by</em><em> Foos Frequency Questionnaires and cognitive function was measured by Moca-INA method,  where as the levels of 4-HNE plasma checked in Bio</em><em>m</em><em>edic laboratory  of Unversitas Andalas.   Statistical  test used  Mann-Whitney test, correlation spearman test, and Krusal-Wallis test with 95% significance level (p&lt;0,05). …”
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Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

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A Turbo‐Charging System‐Like Contrast Agent for MRI‐Guided STING Pathway‐Activated Cancer Immunotherapy by Bin Ren, Sihua Yan, Zongheng Li, Ya Huang, Haobin Cai, Jing Yang, Qingdeng Fan, Chunmei Chen, Fanchao Que, Guochao Wu, Lin Huang, Ruilong Zhou, Jiaoyang Zhu, Chenggong Yan, Gang Liu, Zheyu Shen, Shipeng Ning

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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

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Atmospheric oxidation of 1,3-butadiene: influence of seed aerosol acidity and relative humidity on SOA composition and the production of air toxic compounds by M. Jaoui, K. Nestorowicz, K. Nestorowicz, K. J. Rudzinski, M. Lewandowski, T. E. Kleindienst, J. Torres, E. Bulska, W. Danikiewicz, R. Szmigielski

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Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease by Colin Birkenbihl, Madison Cuppels, Rory T. Boyle, Hannah M. Klinger, Oliver Langford, Gillian T. Coughlan, Michael J. Properzi, Jasmeer Chhatwal, Julie C. Price, Aaron P. Schultz, Dorene M. Rentz, Rebecca E. Amariglio, Keith A. Johnson, Rebecca F. Gottesman, Shubhabrata Mukherjee, Paul Maruff, Yen Ying Lim, Colin L. Masters, Alexa Beiser, Susan M. Resnick, Timothy M. Hughes, Samantha Burnham, Ilke Tunali, Susan Landau, Ann D. Cohen, Sterling C. Johnson, Tobey J. Betthauser, Sudha Seshadri, Samuel N. Lockhart, Sid E. O’Bryant, Prashanthi Vemuri, Reisa A. Sperling, Timothy J. Hohman, Michael C. Donohue, Rachel F. Buckley

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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Safety and tolerability measures comprised adverse events, vital signs, electrocardiography, laboratory tests, physical measurements, and extrapyramidal symptoms with the Simpsons-Angus Scale. …”
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Measurable residual disease as predictor of post–day +100 relapses after allografting in adult AML by Naveed Ali, Megan Othus, Eduardo Rodríguez-Arbolí, Corentin Orvain, Filippo Milano, Brenda M. Sandmaier, Chris Davis, Ryan S. Basom, Frederick R. Appelbaum, Roland B. Walter

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A novel methodology for assessing the hygroscopicity of aerosol filter samples by N. Raparthi, A. S. Wexler, A. S. Wexler, A. S. Wexler, A. S. Wexler, A. M. Dillner

“…To test the method, hygroscopic measurements were conducted in the laboratory for ammonium sulfate, sodium chloride, glucose, and malonic acid, which were collected on 25 mm Teflon filters using an aerosol generator and sampler. …”
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Radiomics signature for dynamic monitoring of tumor inflamed microenvironment and immunotherapy response prediction by Enriqueta Felip, Paolo Nuciforo, Elena Garralda, Joan Frigola, Ramon Amat, Garazi Serna, Francesco Grussu, Kinga Bernatowicz, Olivia Prior, Marta Ligero, Christina Zatse, Rodrigo Toledo, Manel Escobar, Raquel Perez-Lopez

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The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus by Hui Zhang, Minghui Chen, Lijie Sun, Wenwen Zhu, Wenwen Zhu, Tong Niu, Huzaifa Fareeduddin Mohammmed Farooqui, Hongxiao Wang, Bing Song, Jumei Wang, Haoqiang Zhang

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Life cycle greenhouse gas emissions of conventional and alternative steel production methods in countries dependent on energy import: A South Korean case study by Juha Lee, Gyuna Kwak, Yujin Jung, Wonjae Choi

“…The analysis employed the GREET program developed by the Argonne National Laboratory in the United States, modified and expanded to reflect the Korean context. …”
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Exploration of the feasibility of clinical application of phage treatment for multidrug-resistant Serratia marcescens-induced pulmonary infection by Xiangke Duan, Wenfeng Liu, Yanyu Xiao, Man Rao, Liyin Ji, Xiaofu Wan, Shuhong Han, Zixun Lin, Haichen Liu, Peifen Chen, Kun Qiao, Mingbin Zheng, Jiayin Shen, Yang Zhou, Tetsuya Asakawa, Minfeng Xiao, Hongzhou Lu

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Clinical risk score to predict in-hospital mortality in COVID-19 patients: a retrospective cohort study by Adriano Peris, Andrea Ungar, Niccolò Marchionni, Federico Lavorini, Alessandro Bartoloni, Stefano Fumagalli, Rossella Marcucci, Giulia Cesaroni, Riccardo Pini, Carlo Nozzoli, Carlo Fumagalli, Renzo Rozzini, Matteo Vannini, Flaminia Coccia, Francesca Mazzeo, Maria Cola, Paolo Fontanari, Alessandro Morettini, Filippo Pieralli, Loredana Poggesi

“…In the present study, we aimed to develop a clinical risk score to predict the in-hospital mortality in COVID-19 patients, based on a set of variables available soon after the hospitalisation triage.Setting Retrospective cohort study of 516 patients consecutively admitted for COVID-19 to two Italian tertiary hospitals located in Northern and Central Italy were collected from 22 February 2020 (date of first admission) to 10 April 2020.Participants Consecutive patients≥18 years admitted for COVID-19.Main outcome measures Simple clinical and laboratory findings readily available after triage were compared by patients’ survival status (‘dead’ vs ‘alive’), with the objective of identifying baseline variables associated with mortality. …”
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