Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. …”
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Microsatellite instability and somatic gene variant profile in solid organ tumors by Ibrahim Halil Erdogdu, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Nesibe Kahraman-Cetin, Habibe Guler, Merve Turan, Ibrahim Meteoglu

“…Material and methods In this study, the records of 192 patients with solid organ tumors who were referred to the Molecular Pathology Laboratory between January 2018 and December 2022 were reviewed retrospectively. …”
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Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances by Kenneth N. Kikanme, Adcharee Karnjanapiboonwong, Rameshkumar Angappan, Nicole M. Dennis, Farzana Hossain, Jamie G. Suski, Christopher J. Salice, Todd A. Anderson

“…Research has revealed that exposure to environmentally relevant concentrations of PFAS can reduce reproductive success and have immunological effects in laboratory animals, including birds. Further, PFAS can be passed down from parents to offspring, posing a threat to sensitive life stages. …”
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Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia by Jiawei Zhou, Zhifen He, Yidong Wu, Yiya Chen, Xiaoxin Chen, Yunjie Liang, Yu Mao, Zhimo Yao, Fan Lu, Jia Qu, Robert F. Hess

“…Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. …”
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Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China by Lei Chen, Yunlu Sheng, Hanmei Qi, Tingting Tang, Jing Yu, Shan Lv

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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

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Prevalence, associated factors, management and outcomes of hypokalaemia in hospitalised patients at a South African tertiary centre by C Burton, M-Y Chothia, A Zemlin, S Lahri

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Dependence of Water Vapour Adsorption on the Polarity of the Graphene Surfaces of Multi-Wall Carbon Nanotubes by Robert H. Bradley, Aurik Andreu, Kelby Cassity, Susan Osbeck, Rodney Andrews, Mark Meier, Colin Johnston

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Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme by A. J. McCarthy, S. M. O’Reilly, J. Shanley, R. Geraghty, E. J. Ryan, G. Cullen, K. Sheahan

“…We identified all colorectal serrated polyps between 01/01/2004 and 31/05/2016, by searching the laboratory information system for all cases assigned a “serrated adenoma” SNOMED code. …”
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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration by Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta

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16-Channel Hybrid WDM-PDM-MDM (de) Multiplexer for Multi-Band Large-Capacity Optical Transmission System Based on Thick Si<inline-formula><tex-math notation="LaTeX">$_{3}$</tex-mat... by Deyue Ma, Xiwen He, Chen Zhou, Mingyue Xiao, Jiqiao Liu, Weibiao Chen, Zhiping Zhou

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Feasibility, safety and efficacy of high intensity focused ultrasound ablation as a preoperative treatment for challenging hysteroscopic myomectomy by Yuchun He, Min Wu, Xu Guo, Feng Ran, Haiyan Li, Daibi Zhang, Yaqin Wang, Jin Zeng, Xuelian Chen, Linghui Zhai, Xiaohui Li, Tingting Lei

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Subcutaneous Fat Obesity in a High Body Mass Index Donor Is Not a Contraindication to Living Donor Hepatectomy by Hirak Pahari, Amey Sonavane, Amruth Raj, Anup Kumar Agrawal, Ambreen Sawant, Deepak Kumar Gupta, Amit Gharat, Vikram Raut

“…At 3 weeks of follow-up, the donor’s wound is clean and well-healed, and she is already back to doing her daily life activities without any pain with normal laboratory parameters. Conclusion. Subcutaneous fat obesity should not be considered as a contraindication to liver donation even with a BMI >35 kg/m2. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

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A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies by Lucie Perillat, Lucie Perillat, Andrew McFadyen, Andrew McFadyen, Andrew McFadyen, Patricia Furlong, James Anderson, James Anderson, James Anderson

“…Our paper highlights the most critical of these parameters in (1) the planning and development of individualized therapies in laboratory settings, (2) their regulatory oversight, and (3) evaluation. …”
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Valuation method for sub-indicators of rock burst risk based on mining depth and tectonic stress by Zhen LI, Guanyang WU, Shangjin SI, Xin GAO, Xun LIU, Dongdong ZHANG, Chengxiang ZHANG, Jiachen LIU

“…The range of the mining depth and geostress in the numerical research was then determined. Based on laboratory test results, a numerical model was established and simulations of underground excavation were carried out. …”
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Assessment of diversity of Indian aromatic rice germplasm collections for morphological, agronomical, quality traits and molecular characters to identify a core set for crop improv... by G. S. V. Prasad, G. Padmavathi, K. Suneetha, M. S. Madhav, K. Muralidharan

“…Methods The genetic diversity was measured on the distinctness, uniformity and stability (DUS) of 46 traits in 208 Indian ARG in field, greenhouse and laboratory tests. We performed individual and combined analysis of DUS traits and molecular data generated using 55 SSR markers. …”
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The mediating effect of clinical belongingness on the relationship between anxiety and professional identity in nursing interns: a cross-sectional study by Junhao Zhang, Lijia Wang, Xue Yang, Yuwei Yang, Xuehua Wu, Huaping Huang, Guirong Li

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Co-optimization of Demand Response Aggregators and distribution system operator for resilient operation using machine learning based wind generation forecasting: A bilevel approach by Farid Hamzeh Aghdam, Aleksandr Zavodovski, Adeleye Adetunji, Mehdi Rasti, Eva Pongracz, Mohammad Sadegh Javadi, João P.S. Catalão

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SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study by Yue Jin, Fei Yang, Christopher M. Rank, Stanley Letovsky, Peter Ramge, Simon Jochum

“…Methods In this real-world study, laboratory data from individuals tested for SARS-CoV-2 antibodies under routine clinical conditions were linked through tokenization to a United States medical insurance claims database to determine the risk of symptomatic/severe SARS-CoV-2 infection outcomes. …”
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