Impact of ELKa, the Electronic Device for Prandial Insulin Dose Calculation, on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled... by Agnieszka Kowalska, Katarzyna Piechowiak, Anna Ramotowska, Agnieszka Szypowska

“…A randomized, parallel, open-label clinical trial involved 106 patients aged <18 years with T1DM, HbA1C≤10%, undergoing intensive insulin therapy, allocated to the intervention group, who used the ELKa (n=53), or the control group (n=53), who used conventional calculation methods. …”
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Safety and Efficacy of Everolimus Plus Exemestane in Postmenopausal Women with Treatment-refractory Hormone Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Adv... by Yuan-Ching Chang, Kun-Ming Rau, Dar-Ren Chen, Tsu-Yi Chao, Ming-Feng Hou, Chiun-Sheng Huang*

“…Background: This phase IIIb, open-label study enrolled patients from nine Asian and Middle Eastern countries to evaluate the safety and efficacy of the combination therapy in underrepresented patient populations from the Breast Cancer Trials of Oral Everolimus-2 (BOLERO-2). …”
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Measles neutralising antibody levels in patients receiving intravenous immunoglobulin treatment - a sub-analysis of a randomized, cross-over bioequivalence trial. by Vatsala Rajendram, Martyn Paddick, John More

“…<h4>Methods</h4>GMX07 was an open-label, two-period, crossover bioequivalence study which randomized 33 adult patients with primary immunodeficiency disease in 16 centres across the United States, the United Kingdom and Hungary. …”
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Ultrasound-Guided Thoracic Paravertebral Injection of Platelet-Rich Plasma for the Treatment of Thoracic Herpes Zoster-Related Pain: A Study Protocol by Liu Wang, Xinyu Lei, Zhixuan Lan, Ruilin He, Zongbin Jiang

“…Methods This is a prospective, randomized, controlled, open-label, endpoint-blinded, single-center trial involving 128 participants suffering from zoster-associated pain. …”
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InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks by Mahmood Kalemati, Mojtaba Zamani Emani, Somayyeh Koohi

“…In addition to using CharVec, which demonstrates greater accuracy in absolute predictions, InceptionDTA also includes a version that employs simple label encoding and excels in ranking and predicting relative binding affinities. …”
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A Real-Time Semantic Segmentation Method of Sheep Carcass Images Based on ICNet by Shida Zhao, Guangzhao Hao, Yichi Zhang, Shucai Wang

“…We first acquire images of the sheep carcass and use augmentation technology to expand the image data, after normalization, using LabelMe to annotate the image and build the sheep carcass image dataset. …”
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Research on Feature Extracted Method for Flutter Test Based on EMD and CNN by Hua Zheng, Zhenglong Wu, Shiqiang Duan, Jiangtao Zhou

“…The measured signals from a wind tunnel test were manually labeled “flutter” and “no-flutter” as the foundational dataset for the deep learning algorithm. …”
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Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA’s adverse event reporting system database by Qun Li, Wenya Shan, Saiwei Wu

“…The proportional report ratio (PRR), reporting odds ratio (ROR), and Bayesian Confidence Propagation Neural Network (BCPNN) analysis were used to extract data from FAERS for suspected signals referring to the combination of rosuvastatin and fenofibrate.ResultsA total of 68 safety signals were detected from the top 250 AEs in 3,587 reports, of which 28 signals were not included in the drug labels. All the detected AEs were associated with 12 System Organ Classes (SOC), such as gastrointestinal, musculoskeletal and connective tissue, general diseases, investigations and nervous system. …”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…In this study, proteomic analysis revealed that 146 proteins (98 upregulated and 48 downregulated) were differentially identified by label-free LC-MS/MS after DBDCT treatment. Meanwhile, network analysis of these differential proteins suggested that protein Galectin-1 (Gal-1) could regulate the apoptosis process (15 related proteins), which played an essential role in the potential targets of DBDCT-induced hepatotoxicity. …”
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Citrullinated Autoantigen–Specific T and B Lymphocytes in Rheumatoid Arthritis: Focus on Follicular T Helper Cells and Expansion by Coculture by Tim Ammon, Julia Zeiträg, Vanessa Mayr, Manuela Benedicic, Hans‐Peter Holthoff, Martin Ungerer

“…In addition, an innovative assay using dual labeling with CCP–biotin probes allowed for reproducible identification of primary CAS B cells after enrichment with advantages over existing detection methods. …”
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DR-Z2AN: dual-recurrent neural network with a tri-channel attention mechanism for financial management prediction by Salem Knifo, Ahmad Alzubi

“…The established methods for financial management prediction have some flaws, such as the requirement of labeled data, data quality, time complexity, under fitting problems, and longer execution times. …”
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Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells by Melanie Giesen, Erika Fleck, Jürgen Scheele, Tanja Nicole Hartmann, Reinhard Henschler

“…In a competitive murine short-term homing model with i.v. co-injection of Rap1A+B siRNA-treated and control MSCs that were labeled with PKH 26 and PKH 67 fluorescent dyes, the Rap1A+B siRNA-treated MSCs were detected at increased frequencies in blood, liver, and spleen compared to control MSCs. …”
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UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease by Minghua Xu, Xiaomin Zhao, Jiang Zhao, Zhisheng Tan, Chengshi Zhang, Yun Huang, Huiping Zhong, Meifeng Guo, Chen Zhang, Ping Ye, Wentao Zheng

“…The total RNA was extracted from the exosomes, and the level of GFAP and UCH-L1 between the serum exosomes of the two groups was analyzed by a quantitative reverse transcription-polymerase chain reaction and western blot. Exosome labeling and uptake by SH-SY5Y cells were observed by confocal laser microscopy. …”
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Metabolic Differences in Neuroimaging with [¹⁸F]FDG in Rats Under Isoflurane and Hypnorm–Dormicum by Aage Kristian Olsen Alstrup, Mette Simonsen, Kim Vang Hansen, Caroline C. Real

“…In this experiment, we investigate the effect of [¹⁸F]-labeled glucose analog fluorodeoxyglucose ([¹⁸F]FDG) uptake in the brains of rats anesthetized with two commonly used anesthetics for rodents: isoflurane, an inhalation anesthetic, and Hypnorm–Dormicum, a combination injection anesthetic. …”
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Estradiol and progesterone levels in early pregnancy after natural, estradiol + progesterone or gonadotrophin stimulated frozen embryo transfer cycle: a randomised controlled trial... by Nina Freiesleben Mørch, Mette Petri Lauritsen, Pernille Fog Svendsen

“…We aim to investigate serum estradiol and progesterone levels in women who conceived after natural, estradiol and progesterone, or gonadotrophin stimulated frozen embryo transfer.Methods and analysis The study is an open-label, randomised controlled trial with normo-ovulatory women being randomised to natural cycle or estradiol and progesterone substitution and anovulatory women being randomised to estradiol and progesterone substitution or gonadotrophin stimulation. …”
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Real-World Efficacy and Safety of Tafluprost in Primary Open-Angle Glaucoma Patients with Corneal Disorders: A Taiwan Experience by Ju-Kuo Lin, Fu-Tsung Wei, Yi-Chun Liu, Yung-Chang Yen

“…This was a single-arm, open-label, switching study on adult POAG patients treated with latanoprost 0.005% for more than 3 months, with corneal disorders but no dry eye therapy. …”
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Oriented R-CNN With Disentangled Representations for Product Packaging Detection by Jiangyi Pan, Jianjun Yang, Yinhao Liu, Yijie Lv

“…Specifically, we first collect a large number of images of packaged cartons from the real packaging production line and provide detection boxes for them by manual labeling. We have observed that the contextual clues required for different object detection tasks exhibit inconsistency. …”
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Type II Diabetes Patients under Sildenafil Citrate: Case Series Showing Benefits and a Side Effect by Livia M. Zimmermann, Mauricio S. Baptista, João Paulo Tardivo, Maria A. Pinhal

“…However, adverse side effects may involve hypoglycemia. Since off-label use of SC in patients suffering from microcirculatory alterations has increased recently, our results showed that more studies are needed to verify the prevalence of hypoglycemia episodes as well as it's possible physiologic mechanism.…”
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Topical issues of legal regulation of medical humanitarian care in a pandemic by O. E. Karpov, D. N. Nikitenko, V. V. Tretyakov, D. S. Voronov

“…The necessity of developing and adopting a normative act that comprehensively regulates the procedure for organizing, preparing and receiving humanitarian aid, the procedure for its acceptance with verification of the availability of quantity, compliance, labeling, packaging, technical documentation, as well as its compliance with other requirements, has been proved.The article substantiates expediency of the introduction of amendments to some norms of customs regulation, envisaging the possibility of transferring cargo placed under a special customs procedure to other persons according to the decision of the authorized executive body.The relevance and high practical significance of the article is caused by the need for the timely distribution of large  volumes of humanitarian aid in order to effectively prevent and eliminate the consequences of emergencies.…”
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Legal regulation of the circulation of pyrotechnic products in Ukraine and administrative responsibility for its violation by K. L. Buhaichuk

“…These regulations determine the classes of pyrotechnic articles, the legal regime of their free circulation, the responsibilities of economic entities and their identification, labeling of pyrotechnic articles, the procedure for establishing the conformity of pyrotechnic articles, technical requirements for the safety of pyrotechnic articles. …”
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