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2281
Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial
Published 2022-06-01“…The KARDS trial will investigate whether KJD is non-inferior to KR in terms of patient-reported postoperative pain 12 months post-surgery.Methods and analysis KARDS is a phase III, multicentre, pragmatic, open-label, individually randomised controlled non-inferiority trial comparing KJD with KR in patients with severe knee OA, employing a hybrid-expertise design, with internal pilot phase and process evaluation. 344 participants will be randomised (1:1) to KJD or KR. …”
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2282
Optimization of the management of pregnant women with new COVID-19 coronavirus infection: An open prospective cross-sectional study
Published 2024-12-01“…Materials and methods. An open-label prospective continuous cross-sectional study enrolled 114 patients following SARS-CoV-2 infection. …”
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2283
Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study
Published 2025-01-01“…This will provide strong support for the early prediction of BPD and targeted interventions in future research.Methods and analysis This is a prospective, multicentre, open-label, observational cohort study spanning 3 years. …”
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2284
Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade...
Published 2025-02-01“…We investigated intratumoral (IT) administration of CV8102 in patients with anti-programmed cell death protein-1 (PD-1) therapy-naïve or anti-PD-1 therapy-refractory cutaneous melanoma (cMEL) and in patients with advanced cutaneous squamous cell carcinoma, head and neck squamous cell carcinoma and adenoid cystic carcinoma.Methods This open-label, cohort-based, phase I dose escalation study aimed to establish the maximum tolerated dose (MTD), recommended dose (RD), safety and preliminary efficacy of CV8102 as monotherapy or in combination with a PD-1 inhibitor. …”
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2285
Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis
Published 2020-01-01“…In randomized controlled studies in both hard and soft tissue models yielding surgical pain, oliceridine provided effective analgesia with a potential for an improved safety and tolerability profile at equianalgesic doses to morphine. The phase 3, open-label, single-arm, multicenter ATHENA trial demonstrated the safety, tolerability, and effectiveness of oliceridine in moderate to severe acute pain in a broad range of patients undergoing surgery or with painful medical conditions warranting use of an IV opioid. …”
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2286
Comparison of 1D and 3D volume measurement techniques in NF2-associated vestibular schwannoma monitoring
Published 2025-01-01“…For this reason, they are not recommended for monitoring off-label therapy with Bevacizumab or for treatment decisions depending on a precise assessment of tumor volume and growth. …”
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2287
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial.
Published 2022-01-01“…<h4>Design</h4>Two-arm, randomized, open-label controlled trial comparing SOC alone to SOC plus sarilumab. …”
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2289
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2290
Washback of a High-stakes Language Exam on Spanish Teachers' Practice in Brazil
Published 2022-06-01Get full text
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2291
Identifying Organizational Factors and Components Influencing Customer Experience Management Maturity: A Meta-synthesis Approach
Published 2023-12-01“…Findings After analyzing the papers, several codes were extracted and labeled based on similarity and frequency of replication in 10 main themes, 26 concepts, and 116 open codes (with replication). …”
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2292
Effects of the Paediatric Regulation funding on the development of off-patent medicines in children
Published 2025-01-01“…IntroductionIn paediatrics, medicines repurposing is a particularly advantageous approach, offering a route to address unmet medical needs and turn off-label use into evidence-based treatments for paediatric populations. …”
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2293
Budget Impact of Rivaroxaban for the Prevention of Thromboembolic Events after Hip or Knee Replacement in Spain
Published 2016-01-01“…Data related to rate of thromboembolic events, major bleeding events and use of resources (local or general anesthesia and nurse care after surgery) were obtained from the Xarelto® for VTE Prophylaxis After Hip or Knee Arthroplasty (XAMOS) study, an international, non-interventional, observational, open-label study in unselected patients undergoing THR or TKR surgery in routine practice. …”
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2294
A deep learning model for assistive decision-making during robot-aided rehabilitation therapies based on therapists’ demonstrations
Published 2025-01-01“…This assistance provided by the therapist was detected to label those trajectories that were assisted to train a Deep Learning model that learns from the therapist when to assist. …”
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2295
Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3
Published 2025-01-01“…Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining and propidium iodide (PI) staining were used to examine the apoptosis and necrosis of myocardial tissues. …”
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2296
Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain
Published 2025-01-01“…LC–MS/MS proteomic analysis based on the label-free approach was used to detect protein profiles, and volcano plots, Venn diagrams, and clustering heatmaps were used to identify differentially expressed proteins (DEPs). …”
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2297
ϵ-Confidence Approximately Correct (ϵ-CoAC) Learnability and Hyperparameter Selection in Linear Regression Modeling
Published 2025-01-01“…The practical uncertainty of the label samples in the training data set has a major effect in the generalization ability of the learned model. …”
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2298
Developing a Machine Learning–Based Automated Patient Engagement Estimator for Telehealth: Algorithm Development and Validation Study
Published 2025-01-01“…We uniquely leveraged latent vectors corresponding to affective and cognitive features frequently used in psychology literature to understand a person’s level of engagement. Given the labeled data constraints that exist in health care, we explored a semisupervised learning solution. …”
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2299
L’entrepreneuriat touristique local : une opportunité d’inversion du processus de marginalisation d’un centre historique ? Une analyse dans la médina de Fès au Maroc
Published 2022-12-01“…It encourages home-stay accommodation through a label. These local measures have helped disadvantaged families to become involved in the safeguarding and development of the tangible and intangible heritage of the medina. …”
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Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R...
Published 2025-01-01“…This 12‐week double‐blind period was followed by an open‐label extension of ALI/AML treatment through week 52. …”
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