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2261
Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products
Published 2025-01-01“…A total of 49 articles were included based on literature searches. Label comprehension studies, used to support prescription-to-nonprescription switches, are useful in determining how nonprescription products will be used; however, they provide no actual clinical data. …”
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2262
Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder
Published 2022-07-01“…To estimate neuronal density, serial sections were prepared on a cryotome for the above-mentioned brain structures with the subsequent immunohistochemical labeling and confocal microscopy; the neuronal marker (anti-NeuN) was used as the primary antibody. …”
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2263
Diagnosis of Schizophrenia and Its Subtypes Using MRI and Machine Learning
Published 2025-01-01“…The model demonstrated effectiveness (72% accuracy) in estimating the patient's label for a new dataset acquired domestically. Using a linear support vector machine (SVM) on 62 features obtained from MRMR, patients with schizophrenic subtypes were classified with an accuracy of 64%. …”
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2264
Green analysis of illicit drugs on banknote dust
Published 2025-03-01“…A UHPLCHRMS system with ethanol as the organic modifier was used to develop and optimize the chromatographic method; a stable isotope labelled internal standard for each analyte was used to compensate matrix effects and possible losses. …”
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2265
Outcomes and Complications of Minimally Invasive Glaucoma Surgeries (MIGS) in Primary Angle Closure and Primary Angle Closure Glaucoma: A Systematic Review and Meta-Analysis
Published 2025-02-01“…Benjamin Paik,1 Chun Hau Chua,2 Leonard W Yip,1,2 Vivien CH Yip1,2 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, SingaporeCorrespondence: Vivien CH Yip, TTSH Medical Centre, 11 Jalan Tan Tock Seng, Level 1, Singapore, 308433, Singapore, Email vyip82@yahoo.co.ukTopic: To analyse the safety and efficacy of minimally invasive glaucoma surgeries (MIGS) in lowering IOP and medication burden in primary angle closure (PAC) or primary angle closure glaucoma (PACG).Clinical Relevance: MIGS is off-label in angle closure, as implantation of the device is difficult when there is iridotrabecular contact. …”
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2266
Interpretable machine learning and radiomics in hip MRI diagnostics: comparing ONFH and OA predictions to experts
Published 2025-01-01“…Three users with different expertise and backgrounds diagnosed and labeled the dataset into either OA or ONFH. Their results have been compared to our Radiomics-model.ResultsThe amount of handcrafted radiomics features was 1197 before processing; after the final selection, only 12 key features were retained and used. …”
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2267
Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution.
Published 2025-01-01“…Furthermore, some immune cell populations are difficult to label because cervical immunity is less well characterised than systemic immunity. …”
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2268
Lithuanian exile press during five decades of soviet ban
Published 2024-08-01“…This kind of press was labeled by Lithuanian authorities as a weapon of hostile ideology. …”
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2269
High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1
Published 2020-01-01“…Cellular ROS expression was evaluated by CellROX labeling and flow cytometry. Specific antibodies targeting TNFR1 and TNFR2 were used to block TNF-α signaling. …”
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2270
Coproantigen detection and molecular identification of Cryptosporidium species among newborn and adult farm animals
Published 2025-01-01“…Anti-C. parvum IgG PAbs were purified and characterized by SDS-PAGE and then labeled with horseradish peroxidase (HRP). Anti-C. parvum IgG PAbs in-house sandwich ELISA was prepared, then tested this ELISA on 820 samples and compared results with MZN microscopical examination and a commercial sandwich ELISA kit. …”
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2271
Residue depletion profile and withdrawal interval estimation of ivermectin in eggs following topical administration of injectable ivermectin to domestic chickens (Gallus domesticus...
Published 2025-02-01“…IntroductionTopical ivermectin is commonly prescribed extra-label for the control of mite infestations in backyard chicken flocks in the US.MethodsDomestic laying hens (n = 8; 78 weeks of age, weight 1.7–2.2 kg) were administered injectable ivermectin solution topically over the jugular vein (0.4 mg/kg every 7 days for 2 doses). …”
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2272
Financial Management Practices and Financial Performance of Micro Finance Institutions. A Case Study of Lyamujungu SACCO Kabale District.
Published 2023“…This study recommends that Board of Directors ensures that all assets are registered in the asset register and all Physical Assets that belong to Lyamujungu SACCO be engraved and numbered with clear and visible labels.This study recommends that Management to Lyamujungu SACCO should ensure that expenditure done is in line with the planned budget in order to meet its expectations as far as financial performance is concerned. …”
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2273
Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study
Published 2022-07-01“…In this randomised, open label, parallel-group, phase IIa study, we made attempts to conduct a proof-of-concept assessment by evaluating the efficacy and safety of guanabenz acetate treatment in patients with NAFLD/NASH.Methods and analysis A total of 28 adult patients with NAFLD or NASH and hypertension complications meeting the inclusion/exclusion criteria will be enrolled. …”
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2274
Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis
Published 2025-01-01“…ABSTRACT Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain. We conducted this systematic review and meta‐analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain. …”
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2275
First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours
Published 2024-07-01“…Objective The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.Methods and analysis In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. …”
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2276
Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial
Published 2022-07-01“…The objective of the study was to explore the use of long-term home-based ECG monitoring for AF detection and stroke prevention in patients with a history of stroke.Methods and analysis This prospective, randomised, open-label trial with blinded endpoint adjudication aimed to evaluate the efficacy of long-term home-based ECG monitoring for AF detection and stroke prevention in a 24-month period. …”
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2277
MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy
Published 2025-01-01“…Low frequency of this alteration necessitated open-label, single-arm trials to investigate MET inhibitors. …”
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2278
Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding?
Published 2020-07-01“…Important strategies to improve molecular identification of fungi are: (1) broadly document intraspecific and intragenomic variation of barcoding markers; (2) substantially expand sequence repositories, focusing on undersampled clades and missing taxa; (3) improve curation of sequence labels in primary repositories and substantially increase the number of sequences based on verified material; (4) link sequence data to digital information of voucher specimens including imagery. …”
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2279
Hydroxychloroquine plus personal protective equipment versus personal protective equipment alone for the prevention of laboratory-confirmed COVID-19 infections among healthcare wor...
Published 2022-06-01“…Objectives To determine whether hydroxychloroquine when used with personal protective equipment reduces the proportion of laboratory-confirmed COVID-19 among healthcare workers in comparison to the use of personal protective equipment alone.Design Multicentre, parallel-group, open-label randomised trial. Enrolment started on 29 June 2020 and stopped on 4 February 2021. …”
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2280
A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes
Published 2018-01-01“…This study is aimed at comparing the short-term (over a period of 12 days) effects of basal insulin glargine plus OHAs and continuous subcutaneous insulin infusion (CSII) on glycemic control and beta-cell function in this setting. Methods. An open-label parallel-group study. Newly diagnosed hospitalized patients with type 2 diabetes and fasting plasma glucose (FPG) ≥11.1 mmol/L or glycated hemoglobin (HbA1c) ≥9% (75 mmol/mol) were randomized to CSII or insulin glargine in combination with metformin and gliclazide. …”
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