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2141
Effect of potato glycoside alkaloids on mitochondria energy metabolism of Fusarium solani, the root rot pathogen of Lycium barbarum
Published 2025-01-01“…This study employed tandem mass labeling (TMT) quantitative proteomics technology to investigate the antifungal mechanism of potato glycoside alkaloids (PGA) against Fusarium solani. …”
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2142
Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons
Published 2025-01-01“…To assess neuronal uptake, α-syn seeds were covalently labelled with an Alexa-Fluor 488 fluorescent tag, pre-incubated with R18D (0.125, 0.25, 0.5 μM), and then exposed to cortical neurons for 24 h and assessed via confocal microscopy. …”
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2143
EMNet: A Novel Few-Shot Image Classification Model with Enhanced Self-Correlation Attention and Multi-Branch Joint Module
Published 2025-01-01“…Traditional models require a large amount of labeled data for training, while few-shot learning trains models using only a small number of samples (just a few samples per class) to recognize new categories. …”
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2144
BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes
Published 2021-01-01“…Incubation with BMSC-Exos could significantly improve the survival rate, migration ability, and chondrocyte-specific genes (COL2A1, SOX9, Agg, and Prg4) and miR-326 expression of OA chondrocytes and significantly inhibit pyroptosis of chondrocytes by downregulation of the levels of inflammatory cytokines, Caspase-1 activity, and pyroptosis-related proteins such as GSDMD, NLRP3, ASC, IL-1β, and IL-18 (P<0.01). PKH26 labeling confirmed the uptake of BMSC-Exos by chondrocytes. …”
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2145
tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells
Published 2025-02-01“…Here, we used two cargo proteins (NPY and tPA) labeled with different fluorescent proteins (mCherry GFP and eGFP) and employed total internal reflection fluorescence microscopy (TIRF‐M) to capture distinct single‐granule and multi‐granular fusion events. …”
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2146
Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis
Published 2023-01-01“…TdT-mediated dUTP nick-end labeling (TUNEL) assays were used to calculate the apoptosis rate of cartilage. …”
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2147
The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomize...
Published 2025-01-01“…<h4>Methods</h4>The study is an open-label, multicenter randomized clinical trial testing the effectiveness and safety of pre-extubational loading dose of caffeine citrate. …”
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2148
SkelETT—Skeleton-to-Emotion Transfer Transformer
Published 2025-01-01“…Following this foundational knowledge acquisition, the model undergoes fine-tuning on a smaller, labeled dataset tailored for emotion classification tasks. …”
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2149
An In Vitro Model of Diabetic Retinal Vascular Endothelial Dysfunction and Neuroretinal Degeneration
Published 2021-01-01“…The VEGF expression was assessed by ELISA. RGCs were labeled by neurons and RGC markers TUJ1 and BRN3A for quantitative and morphological analysis. …”
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2150
Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY stud...
Published 2025-02-01“…Methods A multicenter, open-label, active-controlled, non-inferiority randomized study will be conducted at 11 sites in Japan. …”
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2151
Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression
Published 2025-01-01“…Herein, we assessed the feasibility of using a 68Ga-labeled anti-PD-L1 nanobody, 68Ga-NODAGA-NM-01, for PET imaging of PD-L1. …”
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2152
Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study
Published 2024-08-01“…Objective The study was to evaluate the diagnostic value of aluminium-[ 18 F]fuoride(Al 18 F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS. …”
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2153
Safety and Efficacy of Hydroxypropyl Guar-Hyaluronic Acid Dual-Polymer Lubricating Eye Drops in Indian Subjects with Dry Eye: A Phase IV Study
Published 2024-12-01“…Methods This prospective, open-label, single-arm, phase IV study was conducted in India. …”
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2154
Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study
Published 2025-12-01“…However, there is a paucity of data on IM tolerability by injection site to guide mAb development. This Phase 1, open-label trial randomized healthy adults to receive 62.5 mg/mL sotrovimab IM into each dorsogluteal muscle (2 × 4 mL injections), or 100 mg/mL sotrovimab IM into the dorsogluteal muscle (1 × 5 mL), the anterolateral thigh muscle (1 × 5 mL) or each deltoid muscle (2 × 2.5 mL). …”
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2155
Long-term efficacy and safety of alemtuzumab in participants with highly active MS: TOPAZ clinical trial and interim analysis of TREAT-MS real-world study
Published 2025-02-01“…Sustained efficacy up to 9 years was observed in the phase IIIb/IV open-label TOPAZ clinical trial and assessed in the real-world retrospective and prospective study, TREAT-MS. …”
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2156
Proteomics and metabolomics analyses of mechanism underlying bovine sperm cryoinjury
Published 2025-01-01“…The molecular mechanism of decreased sperm motility caused by cryoinjury was explored through a joint analysis of 4D-label free quantitative proteomics and non-targeted metabolomics. …”
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2157
Microsatellite loci variability in apple cultivars developed at VIR
Published 2021-10-01“…A set of 10 SSR markers (CH02c02b, CH03d01, CH01f03b, CH02d08, CH02c02a, CH05e03, CH02c09, CHVf1, CH01h01, COL) was used for genotyping 35 apple cultivars developed at VIR and four parental forms. Fluorescently labeled PCR products were separated by capillary electrophoresis on ABI Prism 3130xl.Results. …”
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2158
Biologic Cost per Effectively Treated Rheumatoid Arthritis Patient in a Large Managed Care Population: A Retrospective Cohort Study
Published 2015-09-01“…The algorithm defined effectiveness during the 12-month post-index period as achieving all six of the following: high adherence (medication possession ratio ≥80% or infusions consistent with the product label); no increase in biologic dose or decrease in dosing interval; no new biologic; no new nonbiologic disease-modifying antirheumatic drug; no new or increased oral glucocorticoid use; and ≤1 glucocorticoid injection. …”
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2159
Proteomic profiling of Labeo rohita intestine infected with Edwardsiella tarda: Unveiling the mucosal defense mechanisms, cell adhesion, and cytoskeletal pathways
Published 2025-06-01“…Histopathology was performed to overview changes in rohu intestine. Label-free quantitative proteomic analysis of the rohu intestine was performed to elucidate the proteome changes and its implications for immune response. …”
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2160
Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset
Published 2025-01-01“…However, existing person detection models designed for aerial images heavily rely on numerous labeled instances and exhibit limited tolerance towards complex lighting conditions commonly encountered in search and rescue (SaR) scenarios. …”
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