A novel machine learning methodology for the systematic extraction of chronic kidney disease comorbidities from abstracts by Eszter Sághy, Mostafa Elsharkawy, Frank Moriarty, Sándor Kovács, István Wittmann, Antal Zemplényi, Antal Zemplényi

“…Abstracts about a disease affecting CKD development and/or progression were selected by multiple ML classifiers trained on a human-labelled sample. The best classifier was further trained with active learning. …”
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Designing Microfluidic Devices to Sort Haematopoietic Stem Cells Based on Their Mechanical Properties by Mingming Du, Dean Kavanagh, Zhibing Zhang, Neena Kalia

“…This study tested whether this could be achieved using label-free microfluidic devices. Methods. 2 straight (A-B) and 3 spiral (C-E) devices were fabricated with different dimensions. …”
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Temporal Convolutional Network Approach to Secure Open Charge Point Protocol (OCPP) in Electric Vehicle Charging by Ikram Benfarhat, Vik Tor Goh, Chun Lim Siow, Muhammad Sheraz, Teong Chee Chuah

“…The proposed model achieved 100% accuracy in detecting binary labels and 5-class scenarios, and 93% accuracy in identifying 17-class attack types, surpassing existing approaches. …”
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Feasibility, safety and tolerability of estrogen and/or probiotics for improving vaginal health in Canadian African, Caribbean, and Black women: A pilot phase 1 clinical trial. by Biban Gill, Jocelyn M Wessels, Christina L Hayes, Jenna Ratcliffe, Junic Wokuri, Elizabeth Ball, Gregor Reid, Rupert Kaul, Jesleen Rana, Muna Alkhaifi, Wangari Tharao, Fiona Smaill, Charu Kaushic

“…Considering the high prevalence of BV among African, Caribbean and Black (ACB) women, we conducted a prospective, randomized, open-label phase 1 clinical trial to determine the feasibility, safety and tolerability of administering low-dose estrogen, probiotics or both in combination to improve vaginal health and decrease HIV-1 susceptibility.…”
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Impact of strict IGF1 control on quality-of-life scores in patients with acromegaly by Chaitanya Gandhi, Marie-Claire Denis, Daniel Holmes, Juan Rivera, Stan van Uum, Shereen Ezzat, Constance Chik

“…ObjectiveExamine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results in clinical and health-related quality of life benefits in patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study.MethodsIn patients with acromegaly and modest IGF1 elevation, strict IGF1 control was achieved by addition or dose escalation of pegvisomant. …”
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NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy by Manuela Osorio, Isabel Velásquez, Ruben Vargas, Adriana Vanegas-García, Mauricio Rojas, Gloria Vásquez, Carlos Muñoz-Vahos

“…Cell viability and purity were evaluated by flow cytometry after staining with PI/DiOC6 and labeling with fluorescent anti-CD45/anti-CD3 monoclonal antibodies (mAbs), respectively. …”
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Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain by Xuelian Meng, Xueliang Zhu, Xiangwei Wang, Rui Zhang, Zhidong Zhang, Yuefeng Sun

“…Results In this study, a global profile of the succinylome in Vero cells infected with PPRV Nigeria 75/1 vaccine strain (PPRVvac) was performed by dimethylation labeling-based quantitative proteomics analysis. A total of 2633 succinylation sites derived from 823 proteins were quantified. …”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Beatriz Tavira, Hugo Barcenilla, Jeannette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Rosaura Casas

“…GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to promising results from other trials. …”
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Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson’s Disease with Motor Fluctuations by John C. Morgan, Rohit Dhall, Robert Rubens, Sarita Khanna, Suneel Gupta

“…CD-LD + entacapone (CLE; ASCEND-PD) in subjects with advanced PD included a 6-week, open-label conversion to ER CD-LD prior to treatment randomization. …”
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FERA-Net: A Novel Algorithm for Mars Water-Ice Cloud Segmentation Integrating Feature Enhancement, Residual, and Attention Mechanisms by Xu Ma, Jialong Lai, Zhicheng Zhong, Feifei Cui

“…This study proposes the Feature-Enhanced Residual Attention U-Net (FERA-Net) model, which is trained using cloud mask label data generated by the semiautomatic CM7 method. …”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Methods Intestinal mucosal biopsy tissue specimens of inflamed (ulcerative colitis-inflamed, UC-I) and non-inflamed (ulcerative colitis-noninflamed, UC-N) tissue were obtained simultaneously during colonoscopy from newly diagnosed UC patients prior to any treatments. Label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) quantitative proteomics was used to detect proteomic differences between UC-I, UC-N, and normal control subjects (n = 5). …”
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Human umbilical cord derived-mesenchymal stem cells alleviate lipid metabolism disturbances of hepatocytes via mitochondrial transport by Jing Xue, Xiangnan Hu, Suying Xia, Pengfei Ren, Aihong Wang

“…MitoTracker Red dye was used to label MSCs mitochondria, and flow cytometry showed that over 90 ​% of HepG2 cells had MitoTracker Red positive mitochondria, indicating a significant transfer of mitochondria from UC-MSCs to HepG2 cells. …”
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Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…The temporal trends in clinical trial activity after CTA enactment were examined.Results A total of 577 CTA-compliant specified clinical trials (ie, studies funded by pharmaceutical companies or studies evaluating the efficacy and safety of off-label drugs or devices in humans) were registered in the jRCT. …”
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Exercise-Intervened Circulating Extracellular Vesicles Alleviate Oxidative Stress in Cerebral Microvascular Endothelial Cells Under Hypertensive Plus Hypoxic Conditions by Smara Sigdel, Shuzhen Chen, Gideon Udoh, Jinju Wang

“…Age- and sex-matched sedentary Alb1-Ren mice served as controls. cEVs were isolated from the blood of exercised and sedentary mice and are denoted as ET-cEV and nET-cEV, respectively. cEVs were labeled to determine their uptake efficiency and pathways. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Objective To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.Design Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sources MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. …”
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Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI by Liam Timms, Tianyi Zhou, Ju Qiao, Codi Gharagouzloo, Vishala Mishra, Rita Maria Lahoud, John W. Chen, Mukesh Harisinghani, Srinivas Sridhar

“…Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. …”
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Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018) by Alessio Strazzulla, Maria Concetta Postorino, Nabil Belfeki, Laura Iordache, Astrid de Pontfarcy, Aurelia Pitsch, Pierre Leroy, Sebastien Jochmans, Mehran Monchi, Sylvain Diamantis

“…Overall, 3332 patients were included, 132/3332 (3.9%) were labelled β-lactam allergic, while 3200/3332 (96.1%) did not presented β-lactam allergy. …”
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Effects of prenatal exercise interventions on maternal body composition: A secondary analysis of the FitMum randomized controlled trial. by Caroline Borup Roland, Parisa Seyedhosseini, Signe de Place Knudsen, Anne Dsane Jessen, Ida Karoline Bach Jensen, Jane M Bendix, Gerrit van Hall, Stig Molsted, Saud Abdulaziz Alomairah, Ellen Løkkegaard, Bente Stallknecht, Tine D Clausen

“…Maternal body composition was measured by doubly labeled water at 28 weeks gestation (n = 134) and by dual-energy X-ray absorptiometry scan 7-14 days after delivery (n = 117). …”
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Green synthesis of iron nanoparticles to promote seed germination of Zea mays under salinity condition by Hiba Fouad Abdulfatah, May Fahmi Abdulrahman, Enas Fahd Naji

“…The synthesized Fe NPs were spherical and have around 12 nm in size, with a 5.5 mV value, the synthesized Fe NPs were stable.The effects of these (Fe NPs) on the germination of maize (Zea mays L.) labeled Z1(Buhooth 5018), Z2(Baghdad-3) and Z3 (Fajr-1) seeds and the growth of their roots were assessed under conditions of salinity at different levels (0, 8, 12 ds m−1) in a laboratory-scale system. …”
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Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponso... by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

“…In our previous pilot work, morning bright light therapy (MBLT) was found to be a feasible behavioral sleep intervention in Veterans with a history of mTBI; however, this was single-arm, open-label, and non-randomized, and therefore was not intended to establish efficacy. …”
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