Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…We identify seizures only in the Syn1cre conditional mutant (cKO); hyperactivity, learning difficulties, social deficits, and impulsivity in the Syn1cre and Vgatcre cKOs; and social deficits, and fear learning deficits in L7cre cKOs. To our knowledge, we are the first to describe the behavioral contributions of Nprl2's function across multiple cell types. …”
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Sewage pollution from onsite sewage disposal systems and an offshore wastewater treatment plant outfall in coastal waters of Keaukaha, Hawaiʻi Island by Shayla M.P. Waiki, Steven L. Colbert, Tracy N. Wiegner, Noelani Puniwai, Joseph W.P. Nakoa, III, Nicolas M. Storie, Craig E. Nelson, Ashlynn N. Overly, Karla J. McDermid, Devon K. Aguiar

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Users’ Perspectives of Direct-to-Consumer Telemedicine Services: Survey Study by Kate Churruca, Darran Foo, Andrew Turner, Emily Crameri, Maree Saba, Samantha Spanos, Matthew Vickers, Jeffrey Braithwaite, Louise A Ellis

“…Most participants felt “more in control” (106/128, 82.9%) and “in charge” of their health concern (102/130, 78.5%) when using DTC telemedicine services, in addition to having “more correct knowledge” (92/128, 71.9%) and “feeling better informed as a patient” (94/131, 71.8%). …”
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Mark loss can strongly bias estimates of demographic rates in multi-state models: a case study with simulated and empirical datasets by Touzalin, Frédéric, Petit, Eric J., Cam, Emmanuelle, Stagier, Claire, Teeling, Emma C., Puechmaille, Sébastien J.

“…In this study, we focus on the issue of mark loss and the associated recycling of remarked individuals, which requires further exploration given the increasing use of these models. 2. To fill this knowledge gap, we employed a wide range of simulation scenarios that reflect commonly encountered real case studies, drawing inspiration from the survival rates of 700 vertebrate species. …”
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Specific detection of pigeon parvovirus with TaqMan real-time PCR technology by Cuiteng Chen, Chunhua Zhu, Shuyu Chen, Zhen Chen, Huanru Fu, YuYi Chen, Mengyan Zhang, Wenyu Zhang, Yu Huang, Longfei Cheng, Chunhe Wan

“…Owing to the failure to propagate PiPV in embryos and cells, knowledge of PiPV replication mechanisms in birds still needs further study. …”
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Deciphering the role of epigenetics in plant pathogen resistance: Strategies for sustainable sugarcane management by Faisal Mehdi, Yuanli Wu, Shuzhen Zhang, Yimei Gan, Zhengying Cao, Shuting Jiang, Limei Zan, Benpeng Yang

“…This review offers a comprehensive overview of current knowledge regarding the epigenetic mechanisms that support sugarcane's defense against pathogens. …”
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Early Detection of Oncological Diseases of the Digestive System (Guidelines of the Russian Gastroenterological Association and the Russian Association of Oncologists for Primary Ca... by V. T. Ivashkin, I. V. Mayev, A. D. Kaprin, M. Yu. Agapov, D. N. Andreev, A. S. Vodoleev, M. Yu. Zharkova, M. P. Korolev, Yu. A. Kucheryavyi, T. L. Lapina, M. V. Mayevskaya, A. V. Okhlobystin, Ch. S. Pavlov, A. V. Paraskevova, S. S. Pirogov, E. A. Poluektova, D. E. Rumyantseva, A. S. Trukhmanov, P. V. Tsarkov, A. A. Sheptulin, O. S. Shifrin

“…Each section offers practical algorithms in cases of suspected esophageal adenocarcinoma, esophageal squamous cell carcinoma, gastric cancer, colorectal cancer, hepatocellular carcinoma and extrahepatic bile duct and gallbladder cancer, as well as pancreatic cancer.Conclusion. The knowledge of clinical manifestations and risk factors in the development of digestive system neoplasms allows a physician to suspect cancer and devise a timely and adequate diagnostic strategy, including laboratory and instrumental studies at specialised clinical centres.…”
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Investigation on willingness of psychiatric nurses to engage in dementia nursing and influencing factors analysis (精神科护士从事失智症护理工作意愿调查及影响因素分析)... by GU Liqin (顾丽琴), JI Caifang (季彩芳), TANG Xiaofang (唐晓芳)

“…Conclusion It is suggested to strengthen the training of psychiatric nurses on dementia related knowledge, theory and care skills, arrange nurses to care for dementia patients, change nurses' cognition of dementia nursing work, strengthen the training of nurses interested in the nursing work of dementia patients, improve their clinical working ability and provide better nursing services for dementia patients. …”
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TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis by Haitao Li, Haitao Li, Yuanyuan Chu, Yuanyuan Chu, Liyuan Jiang, Liyuan Jiang, Lei Li, Lei Li, GuoDong Lv, Yuansheng Liu, Chunhou Zheng, Chunhou Zheng, Yansen Su, Yansen Su

“…In this study, we propose a transfer learning-based model, namely TransferBAN-Syn, to identify synergistic drug combinations against echinococcosis based on abundant information of drug combinations against parasitic diseases. To the best of our knowledge, this is the first work that leverages transfer learning to improve prediction accuracy with limited drug combination data in echinococcosis treatment. …”
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Composite Study of Relationships Between the Characteristics of Atlantic Cold Tongue: Onset, Duration, and Maximum Extent by Dianikoura Ibrahim Koné, Adama Diawara, Benjamin Komenan Kouassi, Fidele Yoroba, Kouakou Kouadio, Assi Louis Martial Yapo, Touré Dro Tiemoko, Mamadou Diarrassouba, Foungnigué Silué, Arona Diedhioune

“…However, as the changes in the end date are greater than those in the onset date, the duration of the ACT has been 5–12 days shorter in the last 20 years than in the previous 20 years. Knowledge of these ACT characteristics and their interrelations and drivers is crucial for understanding the West African Monsoon System and for improving climate models and seasonal forecasts.…”
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Penerapan Metode Association Rule Mining untuk Asosiasi Ulasan Terhadap Aspek Tempat Wisata Jawa Timur Park 3 by Aisyatul Maulidah, Fitra A. Bachtiar

“…The Association Rule Mining (ARM) technique is a text mining method that can support the knowledge discovery process in large document collections. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…Obesity is a major factor in the onset of chronic inflammatory diseases (CIDs). Yet, several knowledge gaps remain: For several CIDs, inconsistent results have been reported, relating to their obesity-imposed risk, data on most rare CIDs remain unavailable, sex differences and racial disparities remain mostly unaddressed.MethodsA large-scale cohort study compared the risk of developing 46 CIDs in individuals with overweight/obesity (n=3,101,824) to an equal number of non-overweight/obese individuals. …”
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Functional Tests and Surveys Used to Assess Nervous System Dysfunction in Patients with Fabry Disease – A Review by Stanislaw Jesionek, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Partycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Justyna Jankowska

“…This review aims to evaluate functional tests and surveys used to assess nervous system dysfunction, focusing on the autonomic nervous system in FD patients. State of Knowledge: Fabry disease presents with classical and non-classical phenotypes, with early symptoms in males often involving pain, skin lesions, and gastrointestinal disturbances, progressing to more severe manifestations like heart failure and renal disease. …”
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Ethnobotanical survey on anti-tuberculosis plants in Mbujimayi, Democratic Republic of the Congo by Malangu Lambert Muamba, Kitambala Marsi Mbayo, Numbi Evodie Wa Ilunga, Ilunga Eddy Mbuyu, Kabeya Justin Kanda, Otete François Dikala, Ebalantshim Daniel Munakongo, Mwinensenge James Maloba, Nonga Welcome Muyumba, Kalonji Serge Mbuyi, Muya Richard Kalunga, Tsheko Manya, Kihuya Eddy Ngoy, B. J. Kanangila, Mutombo Emery Kalonda, Kankenza Léonard Kalanda, Simbi Jean-Baptiste Lumbu, Clement L. LIYONGO

“…It provides valuable insights into the knowledge of resource persons and traditional practitioners. …”
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Dynamic Associations of Change in Physical Activity and Change in Cognitive Function: Coordinated Analyses of Four Longitudinal Studies by Magnus Lindwall, Cynthia R. Cimino, Laura E. Gibbons, Meghan B. Mitchell, Andreana Benitez, Cassandra L. Brown, Robert F. Kennison, Steven D. Shirk, Alireza Atri, Annie Robitaille, Stuart W. S. MacDonald, Elizabeth M. Zelinski, Sherry L. Willis, K. Warner Schaie, Boo Johansson, Marcus Praetorius, Roger A. Dixon, Dan M. Mungas, Scott M. Hofer, Andrea M. Piccinin

“…A series of multilevel growth models with physical activity included both as a fixed (between-person) and time-varying (within-person) predictor of four domains of cognitive function (reasoning, memory, fluency, and semantic knowledge) was used. Baseline physical activity predicted fluency, reasoning and memory in two studies. …”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…This study sought to address the knowledge gap by integrating transcriptomic and metabolomic analyses to elucidate the intricate mechanisms. …”
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Form of Communication for Teaching Bajo Children The Local Values in Utilizing Natural Marine Resources by La Ode Jumaidin, Irawati Irawati, Sumiman Udu, Hasddin Hasddin, Osu Oheoputra Husen

“…The issue behind the research on the Bajo tribe is the lack of understanding regarding the forms of communication used by the tribe to impart knowledge about local wisdom concerning the sustainable use of coastal and marine resources. …”
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Identifying the healthy places to live in Australia with a new environmental quality health index by Shuang Zhou, Zhihu Xu, Wenzhong Huang, Yao Wu, Rongbin Xu, Zhengyu Yang, Pei Yu, Wenhua Yu, Tingting Ye, Bo Wen, Shanshan Li, Yuming Guo

“…Conclusions: We established, to our knowledge, the first tool to quantify and communicate environmental health risks using three types of mortality data and 12 environmental factors. …”
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Identification of Nontuberculous Mycobacteria in Patients with Pulmonary Diseases in Gyeongnam, Korea, Using Multiplex PCR and Multigene Sequence-Based Analysis by Min-Jeong Kim, Kyu-Min Kim, Jeong-Ih Shin, Jong-Hun Ha, Dong-Hae Lee, Jeong-Gyu Choi, Jin-Sik Park, Jung-Hyun Byun, Jung-Wan Yoo, Seokyong Eum, Myunghwan Jung, Seung Chul Baik, Woo Kon Lee, Hyung Lyun Kang, Min-Kyoung Shin

“…The results of this study suggest a strategy for rapid detection and accurate identification of species using two-step mPCR and multigene sequence-based analysis. To the best of our knowledge, this study is the first to report the identification of NTM species isolated from patients in Gyeongnam/Korea.…”
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Profiling Key Phytoconstituents in Screw-Pressed <i>Nigella</i> Solid Residue and Their Distribution in Products and Byproducts During Oil Processing by Parbat Raj Thani, Joel B. Johnson, Surya Bhattarai, Tieneke Trotter, Kerry Walsh, Daniel Broszczak, Mani Naiker

“…Additionally, there is a knowledge gap relating to how phytoconstituents transfer from seeds to solid residue during oil extraction and any loss of key phytoconstituents that may occur during this transfer. …”
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