Detections of antimicrobial resistance phenotypes and extended-spectrum beta-lactamase (ESBL)- producing Salmonella spps and Escherichia coli O157:H7 in raw vegetables and fruits f... by Ahmed Zeynudin, Teshome Degefa, Tariku Belay, Jiru Batu Mumicha, Abdusemed Husen, Jafer Yasin, Abdulhakim Abamecha, Andreas Wieser, Mengistu Abayneh

“…Abstract Objectives Despite of the health benefits of consumption of fresh vegetables and fruits, this product could be associated with food-borne bacterial pathogens, including infections with antibiotic-resistant strains especially in developing countries due to limited in knowledge, and hygienic practices. This study was conducted to provide evidence data on the rates of Salmonella spp. and E. coli O157:H7 contamination, the antimicrobial resistance profile, and extended-spectrum β-lactamase (ESBL)-producing strains in fresh vegetables and fruits sold in open-air markets at Jimma town, southwest Ethiopia. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…This engineering approach does not require a priori knowledge of structural and functional mapping of antibody–antigen interaction and thus is generally applicable for therapeutic antibody development when desired ortholog binding is lacking. …”
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The development and implementation of an innovative community-based intervention to strengthen community capacity for HIV prevention and care among Canadians of African Caribbean a... by Josephine Etowa, Notisha Massaquoi, Francisca Omorodion, Danielle Brown-Shreves, Ilene Hyman, Akalewold Gebremeskel, Hugues Loemba, Bishwajit Ghose, Egbe Etowa, Jennifer Rayner, Charles Dabone, Lounanjio Brown O’Sullivan, Azeeza Sule, Joseph Kiirya, Sanni Yaya, Wangari Tharao, Haoua Inoua, Angela Kaida, Apondi Odhiambo, Clinton Beckford

“…Phase 1: Community and partner engagement; Phase 2: Critical health and racial literacy training curriculum and HIV resource development; Phase 3: Implementation research with first cohort of trained HIV Peer Equity Navigators [PENs] in three sites; Phase 4: Training of second cohort of HIV PENs and program implementation of HIV PEN intervention across Ontario; and Phase 5: Evaluation, knowledge sharing and plans for national scale up. …”
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Genetic counselling in the era of next generation sequencing by Diego Espada-Musitu, África Manero-Azua, Yerai Vado, Guiomar Perez de Nanclares

“…Given the impact of genetic results in clinical decision-making, specialized knowledge is required of the techniques and methods used in genetic studies, their advantages and limitations, and their potential psychosocial, legal and ethical impact on patients, relatives and health care professionals. …”
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Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…<i>Conclusions:</i> To our knowledge, this is the first study to compare ROP prevalence and screening outcomes across Romanian national centers. …”
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2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity by Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior

“…In this context, the aims of this work are to expand the knowledge about the pharmacophore group responsible for the antileishmanial potential of 2-aminothiophene derivatives. …”
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Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix pro... by Simon Herger, Corina Nüesch, Anna-Maria Liphardt, Christian Egloff, Annegret Mündermann

“…A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters.…”
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A Highly Divergent Mitochondrial Genome in Extant Cape Buffalo From Addo Elephant National Park, South Africa by Deon deJager, Marlo Möller, Eileen Hoal, Paul vanHelden, Brigitte Glanzmann, Cindy Harper, Paulette Bloomer

“…While the Cape buffalo (Syncerus caffer caffer) has been well‐studied across its range with traditional genetic markers over the last 25 years, researchers are building on this knowledge by generating whole genome, population‐level data sets to improve understanding of the genetic composition and evolutionary history of the species. …”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

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The cell colony development is connected with the accumulation of embryogenesis-related proteins and dynamic distribution of cell wall components in in vitro cultures of Fagopyrum... by Magdalena Zaranek, Artur Pinski, Bozena Skupien-Rabian, Urszula Jankowska, Kamila Godel-Jedrychowska, Katarzyna Sala-Cholewa, Katarzyna Nowak, Ewa Kurczyńska, Ewa Grzebelus, Alexander Betekhtin

“…Protoplast culture serves as a valuable research model for studying these processes in detail. This knowledge is particularly relevant for improving common and Tartary buckwheat species. …”
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Blockchain-Based Value-Added Tax System: A Systematic Review by Vahideh Ghanooni Shishavan, Shaban Elahi, Sadegh Dorri Nogoorani, Ali Yazdian Varjani

“…Encryption alone cannot guarantee the privacy of electronic invoices, and while zero-knowledge proofs seem to be a suitable solution, they come with considerable complexities. …”
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Beyond the fever: shotgun metagenomic sequencing of stool unveils pathogenic players in HIV-infected children with non-malarial febrile illness by Patricia Nabisubi, Stephen Kanyerezi, Grace Kebirungi, Ivan Sserwadda, Mike Nsubuga, Grace Kisitu, Patricia Ntege Nahirya, Bonny Mulindwa, George P. Akabwai, Sylvia Nantongo, Adeodata Kekitiinwa, Edgar Kigozi, Nsubuga Moses Luutu, Fred Ashaba Katabazi, Leymon Kalema, Andrew Katabalwa, Daudi Jjingo, Gerald Mboowa

“…By revealing potential pathogenic actors beyond the fever, this work demonstrates how metagenomic sequencing may improve our knowledge of infectious illnesses in vulnerable groups and inspire targeted therapies for better clinical care and outcomes.…”
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Association between sperm motility in thawed semen and pregnancy rate in Mediterranean buffaloes by Armando Quintero-Moreno, Carla Osorio Meléndez, Héctor Nava-Trujillo, Jorge Rubio Guillén, Juan Carlos Gutiérrez-Añez, Adriana Camacho de Gutiérrez

“…The association of sperm motility to fertility and/or pregnancy rate (PR) has yielded controversial results. To contribute to knowledge in buffalo reproduction, an experiment was carried out where four sperm motility descriptors (VCL: curvilinear velocity, VSL: straight-line velocity, VAP: average path velocity, and LIN: linearity) were evaluated using a Computerized Semen Analysis System (Sperm Class Analyzer®, CASA System, Barcelona, Spain) in samples obtained from 8 frozen-thawed straws of 8 Mediterranean buffaloes. …”
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Importance and fitness of family medicine milestone project from America to Taiwan by Shih-Ming Li, Yaw-Wen Chang, Ming-Nan Lin, Chi-Wei Lin, Chyi-Her Lin, Cheng-Chieh Li, Ming-Hwai Lin, Yin-Fan Chang, Zih-Jie Sun, Fang-Yih Liaw, Jaw-Shiun Tsai, Shinn-Jang Hwang, Li-Kuang Chen, Jin-Shang Wu

“…Abstract Background The six core competencies of ACGME - patient care (PC), medical knowledge (MK), systems-based practice (SBP), practice-based learning and improvement (PBLI), professionalism (PROF), and interpersonal and communication skills (ICS) - represent domains in which physicians must ultimately demonstrate competence. …”
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Enhancing environmental decontamination and sustainable production through synergistic and complementary interactions of actinobacteria and fungi by Juliana M. Saez, Enzo E. Raimondo, Stefanie B. Costa-Gutierrez, Juan D. Aparicio, Domenica Mosca Angelucci, Enrica Donati, Marta A. Polti, Maria C. Tomei, Claudia S. Benimeli

“…This review provides a critical analysis of the present status of knowledge regarding the potential of actinobacteria-fungi co-cultures with a particular focus on novel functionalities and heightened production efficiency. …”
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Sacredness of the Landscape of Vokė River in the Geography of Tatar Life Stories by Lina Leparskienė

“…Therefore, the second perspective explores Vokė as a space that has attracted people of various denominations in search for help to recover health and spiritual state of mind thanks to knowledge and mysterious power of Tatar healers, known as ‘faldjey’ (Pol. fałdżej). …”
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Mycobiome analyses of critically ill COVID-19 patients by Danielle Weaver, Sara Gago, Matteo Bassetti, Daniele Roberto Giacobbe, Juergen Prattes, Martin Hoenigl, Florian Reizine, Hélène Guegan, Jean-Pierre Gangneux, Michael John Bromley, Paul Bowyer

“…However, specific mycobiome signatures associated with severe COVID-19 in the context of survival and antifungal drug prophylaxis have not yet been determined, and such knowledge could have an important impact on treatment. …”
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Reims/Durocortorum, ville gauloise ? Hypothèses pour une nouvelle problématique des origines de l’agglomération by Robert Neiss

“…This includes both the data that was collected over the course of ancient discoveries, as well as during better documented, more recent excavations. In light of recent knowledge, this renewed examination obliges us to question the hypotheses that we have long relayed. …”
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First clinical cases of leishmaniosis in meerkats (Suricata suricatta) housed in wildlife parks in Madrid, Spain by Pablo Moraleda-Berral, Rosa Gálvez, Eva Martínez-Nevado, Lino Pérez de Quadros, Juncal García, Manuel de la Riva-Fraga, Juan Pedro Barrera, Efrén Estévez-Sánchez, Lourdes Cano, Rocío Checa, María Ángeles Jiménez-Martínez, Ana Montoya, Guadalupe Miró

“…Although no L. infantum DNA was detected in any of sand flies analyzed, it was determined that their food sources were rabbits and humans. Conclusions To our knowledge, this study describes, for the first time, the detection and infection by L. infantum in meerkats (Suricata suricatta). …”
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Tat-fimbriae (“tafi”): An unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway by Anna V. Galeva, Dahe Zhao, Alexey S. Syutkin, Marina Yu Topilina, Sergei Yu Shchyogolev, Elena Yu Pavlova, Olga M. Selivanova, Igor I. Kireev, Alexey K. Surin, Gennady L. Burygin, Jingfang Liu, Hua Xiang, Mikhail G. Pyatibratov

“…Based on protein structure prediction (including AlphaFold 3), tafi exhibits a linear structure: TafC at the tip, TafE acting as an adapter, TafA forming the core filament, and they link the fourth subunit TafF, anchoring tafi to the cell wall. To our knowledge, this is the first case that the Tat-pathway has been linked to the secretion of protein subunits forming prokaryotic filamentous structures.…”
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