Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…BackgroundPregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. …”
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The effects of active play interventions on children’s fundamental movement skills: a systematic review by Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai

“…Methods A systematic literature search was conducted in six electronic databases, Web of Science, PubMed, Embase, Scopus, China National Knowledge Infrastructure (CNKI), and Wan Fang Data, from database inception to May 30, 2024. …”
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PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11 by Pengju Yu, Shuting Ye, Mi Zhou, Long Zhang, Zhongchi Zhang, Xianyun Sun, Shaojie Li, Chengcheng Hu

“…Although considerable effort has been dedicated to identifying transcription factors involved, our knowledge regarding the use of transcriptional regulation strategies to combat azole resistance is currently limited. …”
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Pisa Syndrome in Parkinson’s Disease: Electromyographic Aspects and Implications for Rehabilitation by Giuseppe Frazzitta, Pietro Balbi, Francesco Gotti, Roberto Maestri, Annarita Sabetta, Luca Caremani, Laura Gobbi, Marina Capobianco, Rossana Bera, Nir Giladi, Davide Ferrazzoli

“…In order to improve the knowledge about resting state and during maximal voluntary muscle contraction (MVMC) of the axial muscles, we described the electromyography results of paraspinal muscles, rectus abdominis, external oblique, and quadratus lumborum of both sides of 60 patients. …”
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Key Drivers of Consumption, Conceptual, Sensory, and Emotional Profiling of Cheeses Based on Origin and Consumer Familiarity: A Case Study of Local and Imported Cheeses in Greece by Malamatenia Panagiotou, Efstathios Kaloudis, Danai Ioanna Koukoumaki, Vasiliki Bountziouka, Evangelia Giannakou, Margarita Pandi, Konstantinos Gkatzionis

“…Sensory and emotional attributes of local, local PDO, and imported cheeses, as well as drivers associated with consumers’ choice and acceptance above and beyond their sensory attributes, were studied using three methods: (a) flash profile to gain insight into the sensory positioning of products and description of samples; (b) qualitative analysis of focus groups to pinpoint consumer knowledge, preference, and consumption criteria; and (c) a new methodology for natural language processing and sentiment analysis of social media posts to determine consumer conceptualizations. …”
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Harnessing the Power of Citizen Science for Agroecological Transitions: The Case of the One Million Voices of Agroecology Initiative and Digital Platform by Lisa Elena Fuchs, Lily Cannell van Dien, Maria Rosa ‘Rosy’ Mondardini, Ma Estrella ‘Esther’ Penunia, Irish Baguilat, Sergio Iván Larrea Macías, Marcelo Soares Souza, Eduardo Fernandes Formighieri, Murilo Gelain Gonçalves, Rodrigo B. Westphalen, Vitória Pimentel, Fabio Ricci, Daria Levina, Matthias Geck

“…Its goal was to co-develop a citizen science platform that enables farmers, producer organizations, and consumers around the world to participate in agroecology movements, support agroecology adoption, and contribute to the co-creation and sharing of knowledge on the performance of agroecology. The OMV initiative used a facilitated co-design process that involved a global review, regional partnerships, and structured dialogues in four regions of the world, and a collective prioritization process to develop the scope and features of the emerging platform. …”
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Altered Coactive Micropattern Connectivity in the Default-Mode Network during the Sleep-Wake Cycle by Yan Cui, Qiao Chen, Yang Xia, Zeru Wang, Yujia Guo, Ge Zhang, Dezhong Yao, Daqing Guo

“…Our findings revealed three underlying CAMP networks within the DMN dynamics and deepened the current knowledge concerning FC alterations in the DMN during conscious changes in the sleep-wake cycle.…”
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Operational research as a mechanism to improve treatment outcomes for drug-resistant TB in the WHO European Region by G.B. Migliori, O. Korotych, J. Achar, A. Ciobanu, G. Dravniece, M. Germanovych, E. Gurbanova, A. Hovhannesyan, N. Khachatryan, L. Kuksa, N. Lomtadze, M.L. Rich, A. Skrahina, A. Yedilbayev

“…The project aimed to enhance treatment success, facilitate mSTR implementation, promote quality of care and build research capacity, while also contributing to global knowledge on all-oral mSTR use. Between April 2020 and June 2022, >2,800 patients underwent mSTR treatment in the WHO European Region. …”
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RCE-IFE: recursive cluster elimination with intra-cluster feature elimination by Cihan Kuzudisli, Burcu Bakir-Gungor, Bahjat Qaqish, Malik Yousef

“…The comparability of RCE-IFE is also verified with other biological domain knowledge-based Grouping-Scoring-Modeling (G-S-M) tools, including mirGediNET, 3Mint, and miRcorrNet. …”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…In conclusion, this study pointed out candidate genes potentially associated with adequate glycemic control in T2D patients, contributing to the knowledge of how the glycemic control could systemically influence gene expression.…”
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Parental Technoference and Child Problematic Media Use: Meta-Analysis by Jinghui Zhang, Qing Zhang, Bowen Xiao, Yuxuan Cao, Yu Chen, Yan Li

“…MethodsFollowing PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a comprehensive literature search was conducted up to August 2024 across multiple databases, including Web of Science, EBSCO, ProQuest, PubMed, PsycINFO, and China National Knowledge Infrastructure, using predefined search strings. …”
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Identification of most motivating resource for estimation of social hierarchy in water buffaloes by Sunil Dutt, M.L. Kamboj

“…The con struction of social hierarchy and knowledge of its determinants is warranted for determining the optimum group size and formulating strategies for shifting animals from one group to another. …”
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Activity of sorghum aphid and its natural enemies in the context of agroecological and weather conditions by Tomasz E. Koralewski, Tomasz E. Koralewski, Michael J. Brewer, Leonel L. Deleon, Norman C. Elliott, Kristopher Giles, Adrianna Szczepaniec, Ashleigh M. Faris, Ashleigh M. Faris

“…Agroecological-oriented areawide pest management leverages the innate ability of agroecosystem to suppress pests, and thus to utilize ecosystem services, a key component of sustainable agriculture. A growing body of knowledge on interactions between pests and their natural enemies allows us to recognize the complexity of these interactions that often depend on environmental circumstances. …”
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The role of solar thermal hydrogen production technologies in future energy solutions: A review by Md. Shameem Hossain, Md. Nasirul Islam, Khaza Shahriar, Mohammad Mujtaba Hasan, Md. Sohag Hossain

“…This research fills the knowledge gap by analyzing all solar thermal hydrogen production pathways to compare the identified pathways’ energy, carbon footprint, and cost intensity. …”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…This review aims to address this knowledge gap by examining the effects of MNPs on the fetoplacental unit, a vital structure that serves as the interface between the mother and fetus during pregnancy, as well as on the broader reproductive system. …”
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Locked-in Syndrome: Insights into Etiology, Diagnosis, Management, and Quality of Life by Urszula Zelik, Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…This review consolidates current knowledge on the etiology, diagnosis, management, and quality of life in LIS, emphasizing its complexity and the need for a multidisciplinary approach.The condition’s etiological spectrum includes vascular events, trauma, infections, and demyelinating disorders, necessitating a comprehensive diagnostic approach integrating advanced neuroimaging and electrophysiological tools. …”
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Applying ‘cultural humility’ to occupational therapy practice: a scoping review protocol by Hardeep Singh, Michelle L A Nelson, Heather Colquhoun, Kristina Marie Kokorelias, Tram Nguyen, Ruheena Sangrar, Sachindri Wijekoon, Erica Nekolaichuk, Sofia Mirzazada, Holly Assaf

“…While cultural humility has been broadly examined in healthcare, knowledge gaps exist regarding its application in occupational therapy (OT) practice. …”
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PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…The presented material on an oncopediatrics shows insuffi cient knowledge of scientists concerning advantage of a fascicle of protons over modern methods of photon radiation. …”
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Metabolic redundancy and specialisation of novel sulfide-oxidizing Sulfurimonas and Sulfurovum along the brine-seawater interface of the Kebrit Deep by Rayyan Alamoudi, Alan Barozzi, Grégoire Michoud, Marc W. Van Goethem, Charlene Odobel, Yue Chen, Ramona Marasco, Daniele Daffonchio

“…Despite the significance of these bacteria in primary production being well recognised in several ecosystems, their genomic and metabolic traits in sulfidic deep hypersaline anoxic basins (DHABs) remain largely unexplored. This knowledge gap not only hampers our understanding of their adaptation and functional role in DHABs but also their ecological interactions with other microorganisms in these unique ecosystems. …”
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Characterizing avocado production systems for Ugandan exports: the need for consolidation and support for sustainable development by Peter Sseruwagi, Peter Sseruwagi, Edouard Lehmann, Paul Sigombe, Gabriel Ddamulira, Jan Willem Van Casteren, Pieterjan De Bauw

“…., fertilisers, pesticides, irrigation), using manual labor (family or hired) under mixed cropping systems, but lacking critical infrastructure, agronomic knowledge, extension services, and access to markets. …”
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