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11001
Multivariate quantitative analysis of glycan impact on IgG1 effector functions
Published 2024-12-01“…The regression models developed here provide a quantitative explanation and prediction of the impact of individual glycan features on the binding to FcγRs and bioactivity of the therapeutic protein. To the best of our knowledge, this is the first report of a systematic approach to quantitatively understand the multivariate impact of glycosylation on the effector functionality of therapeutic monoclonal antibodies, providing valuable tools for advancing therapeutic protein development.…”
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11002
Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies
Published 2022-01-01“…Firstly, we retrieved meta-analyses in PubMed, Embase, and China National Knowledge Infrastructure and GWASs in PubMed and GWAS catalog on or before April 7th, 2022. …”
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11003
Diversity of Rhizophydiales (Chytridiomycota) in Thailand: unveiling the hidden gems of the Kingdom
Published 2024-06-01“…By meticulously exploring their morphological characteristics and genetic makeup, we expand the known catalogue of fungal diversity by describing Alphamyces thailandicus, Angulomyces ubonensis, Gorgonomyces aquaticus, G. chiangraiensis, G. limnicus, Pateramyces pingflumenensis, Terramyces aquatica, and T. flumenensis and also provide valuable insights into the intricacies of this order. This newfound knowledge not only enriches our understanding of Rhizophydiales but also contributes significantly to the broader field of mycology, addressing a critical gap in the documentation of fungal species. …”
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11004
ANTHROPOLOGICAL SEARCH FOR VALUE ORIENTATIONS OF A NEW CULTURE BY AURELIUS AUGUSTINE
Published 2019-12-01“…As the direction of their scientific research, the problem of the relationship of reason, faith, knowledge, which has risen sharply in medieval Christian culture, has been considered. …”
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11005
The Distribution of Cytotoxic Necrotizing Factors (CNF-1, CNF-2, CNF-3) and Cytolethal Distending Toxins (CDT-1, CDT-2, CDT-3, CDT-4) in Escherichia coli Isolates Isolated from Ext...
Published 2022-01-01“…Virulent ExPEC is primarily related to groups B2 (60%) and D (32%). Conclusion. To our knowledge, this study demonstrated the presence of cnf2, cnf3, cdt1, cdt2, cdt3, and cdt4 genes for the first time in the literature for Turkey. …”
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11006
Determinants of Malaria Prevention and Treatment Seeking Behaviours of Pregnant Undergraduates Resident in University Hostels, South-East Nigeria
Published 2017-01-01“…The students were more likely to complete their antimalaria medicine when they were sick with malaria infection than for prevention (p=0.0186). Knowledge, academic schedule, cultural influence on perception and decision-making, and accessibility of health facility were key determinants of the women’s preventive and treatment seeking behaviours. …”
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11007
Homeobox genes encoding WOX transcription factors in the flowering parasitic plant Monotropa hypopitys
Published 2017-04-01“…The study of M. hypopitys homeobox genes should contribute to the knowledge about the function of WOX transcription factors and further understanding of the stem cells control mechanisms in mycoheterotrophic species. …”
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11008
Perceptions of Arabic Language Education Students on the Implementation of an Innovative Curriculum | Tashawwurat tullab qism ta'lim al-lughah al-'Arabiyyah hawla tanfidh al-manhaj...
Published 2024-12-01“…This ensures that students not only acquire theoretical knowledge, but also the practical skills needed to succeed in their careers. …”
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11009
Promotive, preventive, and treatment interventions for adolescent mental health in sub-Saharan Africa: A protocol for two scoping reviews including systematic analyses of intervent...
Published 2022-01-01“…<h4>Discussion and dissemination</h4>To the best of our knowledge, these scoping reviews are the first to synthesise a wide range of available evidence on promotive, preventive and treatment interventions for adolescent mental health in sub-Saharan Africa. …”
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11010
The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population
Published 2019-01-01“…The HLA-C⁎12 allele is closely related to the HLA-C⁎06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C⁎12 and psoriasis in the Turkish population. …”
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11011
<i>Macrostomum lignano</i> as a model to study the genetics and genomics of parasitic flatworms
Published 2021-03-01“…Due to the availability of an increasing number of genome and transcriptome assemblies of different parasitic flatworm species, new knowledge generated by studying M. lignano can be easily translated to parasitic f latworms with the help of modern bioinformatic methods of comparative genomics and transcriptomics. …”
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11012
eDNA Metabarcoding Analysis of Bony Fish Identification in Coastal Water of Gulf of Maine Using Nested Polymerase Chain Reaction of 12S rRNA Universal Primers
Published 2024-11-01“…Although beta diversity indicated that fish communities were not different across habitats, statistical analysis found that Pholis sp. and Ammodytes sp. were dominant species in macroalgae and sand, respectively. To our knowledge, this is the first metabarcoding study to assess fish communities in the Western Atlantic region using the MiFish primer set, and the study suggests that metabarcoding is useful for mapping geographic and temporal marine fish diversity.…”
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11013
“No miracle cure” interface evaluation of a UK suicide prevention app in a Norwegian context
Published 2024-12-01“…Self-help apps may potentially reach and support suicidal individuals, next of kin, bereaved and professionals with educational information, access to suicide emergency help, hotlines, and coping tools. Knowledge regarding feasible app interface for suicide prevention self-help apps in a Norwegian context is however lacking.Aim Evaluate user-friendliness and user interface of the Norwegian version of the British Stay Alive suicide prevention app and assess whether the app could be useful in suicide prevention.Materials and Methods Eight Norwegian Fountain house members and twelve university students evaluated the app interface, and their experiences were discussed through individual- or focus-group interviews.Results Participants perceived app tools as relevant and useful for suicide prevention, however they raised concerns on privacy, evidence base, interface complexity, unintended symbolic value of app colours and content, and suitability in suicidal states.Conclusion The current Norwegian Stay Alive version has the potential to be user friendly, however improvements of interface are suggested.Significance Stay Alive interface must be adjusted and subjected to reiterative evaluations and feasibility assessments in collaboration with additional stakeholder populations to remedy interface concerns, and identify optimal Norwegian interface design, prior to implementation.…”
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11014
Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface
Published 2025-01-01“…Post-hoc analyses revealed that the classifier trained on single-task ErrPs exhibited reduced accuracy under hard-task scenarios. To our knowledge, this study is the first to investigate how ErrPs are modulated in a multitasking environment involving both sensorimotor control and BCI operation in an offline framework. …”
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11015
Effect of Oil Content and Emulsifier Type on the Properties and Antioxidant Activity of Sea Buckthorn Oil-in-Water Emulsions
Published 2020-01-01“…Upon storage, the antioxidant activity of the emulsions was decreased due to the changes in emulsion stability and the degradation of antioxidants. The knowledge obtained in this study would be useful in developing healthy food containing sea buckthorn oil.…”
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11016
Do global health networks facilitate innovation, learning and sharing? A qualitative analysis of the Quality-of-Care Network in Bangladesh, Ethiopia, Malawi, and Uganda.
Published 2025-01-01“…We also reviewed all accessible QCN documents. Drawing on knowledge sharing theory, we thematically analysed the qualitative data according to three themes: sharing, learning, and innovations. …”
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11017
A grey wolf optimization approach for evaluating the engine responses of various biodiesel blends in an internal combustion engine
Published 2025-02-01“…The knowledge of the exact thresholds of parameters in the diesel engines, during combustion, is essential to simulate the combustion process, establish parametric values, reduce cost and predict exhaust emissions. …”
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11018
AI-Based Hybrid Models for Predicting Loan Risk in the Banking Sector
Published 2023-12-01“…Accurate forecasting requires knowledge of these machine learning models and their distinguishing features. …”
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11019
Manual wheelchair training programs: a scoping review of educational approaches and intended learning outcomes
Published 2025-01-01“…Training outcomes most commonly related to changes in knowledge/skills of manual wheelchair users (Level 2b of Kirkpatrick’s evaluation (n = 43), with less emphasis on participatory outcomes. …”
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11020
Exploring the Nutritional Potential of Spent Coffee Grounds as a Substitute for Rice Bran in Feeds for Nile tilapia, Oreochromis niloticus: An Evaluation of Growth Performance and...
Published 2024-01-01“…To the researchers’ knowledge, these findings are the first in the field to substitute SCG for rice bran, opening a new avenue for further research.…”
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