Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…The unique detection of sEV signals within the knee joint over time highlights its safety profile by confirming the retention of sEV in the joint. …”
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Arctiin alleviates knee osteoarthritis by suppressing chondrocyte oxidative stress induced by accumulated iron via AKT/NRF2/HO-1 signaling pathway by Junzheng Yang, Delong Chen, Qi He, Baihao Chen, Zhaofeng Pan, Gangyu Zhang, Miao Li, Shaocong Li, Jiacong Xiao, Haibin Wang, Peng Chen, Zhantian An

“…Micro-CT and Safranin O-Fast Green staining were used to detect the phenotype of the knee joints. ARC increased cell viability and inhibited chondrocyte apoptosis. …”
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LITERATURE REVIEW ON GLUCOSAMINE AND CHONDROITIN IN OSTEOARTHRITIS TREATMENT by Dang Thi Soa*, Vu Thi Thuy, Nguyen Duc Trung, Bien Thi Thuc Uyen, Le Thi Hai Yen, Tran Trung Hieu, Tran Thao Linh

“…In Vietnam, osteoarthritis accounts for a high percentage of musculoskeletal conditions, especially affecting the knee joints. Recently, slow-acting anti- osteoarthritis drugs, including glucosamine, chondroitin sulfate, and diacerein, have been suggested as key pharmacological options for treating this condition. …”
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Restoring coronal pre-arthritic alignment in mobile-bearing unicompartmental knee arthroplasty: mid- to long-term outcomes by Yankun Jiang, Changquan Liu, Qidong Zhang, Guoyuan Sun, Ran Ding, Nianfei Zhang, Cheng Huang, Weiguo Wang, Wanshou Guo

“…Of these, 222 knee joints met the inclusion criteria for the study. …”
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Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy by Jiahao Ying, Shijie Li, Anna Ying, Yindong Ding, Xiaoyin Zhu, Jiahao Lin, Kehe Yu

“…In this research, X-ray and Safranin-O staining were employed to evaluate the imageology and histomorphology differences in the knee joints of mice in vivo. Techniques such as Western blot analysis, Enzyme-linked Immunosorbent Assay (ELISA), and immunofluorescence staining were applied to examine protein level changes in vitro experiments. …”
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Quantitative Effects on Proximal Joints of Botulinum Toxin Treatment for Gastrocnemius Spasticity: A 4-Year-Old Case Study by Veronica Cimolin, Manuela Galli, Marcello Crivellini, Giorgio Albertini

“…After 3 months, all joints generally improved their position during gait cycle. Hip and knee joints increased their range of movement and improvements occurred at ankle kinematics and kinetisc, too; a better ankle position and an increase of its capacity of propulsion during terminal stance were evident.…”
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Structural Design and Kinematics Analysis of a Human Lower Limb Rehabilitation Device by Zhang Enhui, Zhao Changrong, Ren Shichao

“…Sensors were attached to the universal joint brackets of the ankle and knee joints, allowing real-time collection and feedback of the patient motion information. …”
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Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period by Toshiyuki Tashiro, Satoshi Seino, Toshihide Sato, Ryosuke Matsuoka, Yasunobu Masuda, Naoshi Fukui

“…This study was conducted to investigate the efficacy of oral hyaluronic acid (HA) administration for osteoarthritis (OA) in knee joints. Sixty osteoarthritic subjects (Kellgren-Lawrence grade 2 or 3) were randomly assigned to the HA or placebo group. …”
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Effects of Juvenile Idiopathic Arthritis on Kinematics and Kinetics of the Lower Extremities Call for Consequences in Physical Activities Recommendations by M. Hartmann, F. Kreuzpointner, R. Haefner, H. Michels, A. Schwirtz, J. P. Haas

“…The gait of JIA-patients can be explained as a crouch-like gait with hyperflexion in hip and knee joints and less plantar flexion in the ankle. A preventive mobility workout would be recommendable to reduce these restrictions in the future. …”
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Design and Evaluation of the AIRGAIT Exoskeleton: Leg Orthosis Control for Assistive Gait Rehabilitation by Mohd Azuwan Mat Dzahir, Shin-Ichiroh Yamamoto

“…The results revealed that the proposed control strategy was able to co-contractively actuate the mono- and bi-articular actuators simultaneously and increase stiffness at both hip and knee joints.…”
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Changes in Mobility of the Golden Hamster with Induction of an IL-1-Induced Arthritis by I. G. Otterness, M. L. Bliven, A. J. Milici

“…Interleukin-1, administered by the intraarticular route into hamster knee joints, resulted in inhibition of spontaneous wheel running activity; however, the effect was transient, lasting only through the evening following IL-1 administration. …”
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Quantitative Effects of Repeated Muscle Vibrations on Gait Pattern in a 5-Year-Old Child with Cerebral Palsy by Filippo Camerota, Manuela Galli, Claudia Celletti, Sara Vimercati, Veronica Cimolin, Nunzio Tenore, Guido M. Filippi, Giorgio Albertini

“…Significant improvements were displayed in terms of kinematics at all lower limb joints, not only at the joint directly involved by the treatment (i.e., ankle and knee joints) but also at proximal joints (i.e., pelvis and hip joint).…”
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In Vivo Magnetic Resonance Imaging and Optical Imaging Comparison of Viable and Nonviable Mesenchymal Stem Cells with a Bifunctional Label by Elizabeth Jane Sutton, Tobias D. Henning, Sophie Boddington, Stavros Demos, Christian Krug, Reinhardt Meier, John Kornak, Shoujun Zhao, Rick Baehner, Sheida Sharifi, Heike Daldrup-Link

“…There was no significant difference between viable and nonviable MSC signal in the knee joints; however, some of the viable cells migrated to an adjacent inflamed ankle joint ( p < .05). …”
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Design and Simulation of Flexible Lower Limb Assisted Exoskeletons Based on the OpenSim by Feng Bolin, Song Peng, Li Ruiyuan, Wei Zuba, Li Qiang, Sun Xichang

“…The influence of different joint assisting combinations on human assisting and the influence of the man-machine coupling model of exoskeletons with different spring stiffness on knee joints, hip joints and ankle joints are studied. …”
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans by Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang

“…The potential usage of Sema3A for OA treatment was validated in mouse and Rhesus macaque OA models through intra-articular injection of Sema3A, and also in patients by administering Sema3A containing platelet-rich plasma into the knee joints. Our studies demonstrated that Sema3A exerts a critical role in inhibiting neurite ingrowth and preventing chondrocyte hypertrophy in cartilage, and could be potentially used for OA treatment.…”
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Three Cases of Previous Smokers with Rheumatoid Arthritis Who Did Not Respond to Tumor Necrosis Factor Inhibitors Were Treated Successfully with an Anti-Interleukin-6 Receptor Anti... by Yasuo Iwata

“…Case 3 is a 48-year-old woman whose smoking index was 560 and had been complaining of pain in both knee joints since 2001. She was treated with adalimumab due to high disease activity but showed no response over the course of 1.5 years. …”
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Xenogenic Implantation of Equine Synovial Fluid-Derived Mesenchymal Stem Cells Leads to Articular Cartilage Regeneration by Mohammed Zayed, Steven Newby, Nabil Misk, Robert Donnell, Madhu Dhar

“…MSCs were fluorescently labeled, and one week after treatment, the knee joints were evaluated for the presence of MSCs to the injured site and at 12 weeks were evaluated macroscopically, histologically, and then by immunofluorescence for healing of the defect. …”
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Biphasic biomimetic scaffolds based on a regionally decalcified bone framework and pre-chondrogenic microspheres for osteochondral defect repair by Zhuo Liang, Qingqing Pan, Fei Xue, Jingdi Zhang, Zhenlin Fan, Weiyun Wang, Xueqiang Guo, Zhuang Qian, Yaping Shen, Wenjuan Song, Lei Wang, Guangdong Zhou, Yong He, Wenjie Ren

“…In vivo experiments indicated that this decalcified bone frame controls the endochondral ossification of PCMs through regionalized angiogenesis, promoting the integrated regeneration and reconstruction of osteochondral defects in rabbit knee joints. These results suggest that our designed demineralized bone frame can precisely engineer the osteochondral regeneration microenvironment, providing theoretical guidance for the integrated regeneration and repair of anisotropic tissue injuries.…”
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Research on the application effect of arthroscopic access modification in meniscal injury repair by Shulin Li, Huayao Sun, Jiahao Zhang, Huiling Guo, Laipeng Yan, Faqiang Tang

“…Conclusion The improved arthroscopic access technique can make the entry and exit of instruments into and out of the joint cavity smoother, improve the surgical field of view, significantly shorten the operation time, reduce the occurrence of intraoperative complications, improve the function of patients’ knee joints earlier, and increase their satisfaction with the operation.…”
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Ketogenic Diet‐Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice by Gabby Dyson, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut, Aleksander Szymczak, Cindy Miranda Brawner, Matlock A. Jeffries

“…At baseline and every two weeks, mechanical allodynia of the operated and contralateral knees was assessed via analgesiometry. Knee joints were collected for histology, gut microbiome analysis was performed on cecal material via 16S sequencing, and serum cytokines were analyzed via Bio‐Plex assay. …”
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