Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Furthermore, tumor necrosis factor-alpha- (TNF-α-) induced expression of phosphorylated c-Jun N-terminal kinases (JNK) and P38 MAPK were inhibited by iguratimod. …”
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Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus by Masako Isokawa

“…Ca2+ and Ca2+-activated kinases control cellular processes of most forms of hippocampal synapse plasticity. …”
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Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset by Richard Witas, Ammon B. Peck, Julian L. Ambrus, Cuong Q. Nguyen

“…Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. …”
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Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer by Hajime Nakamura, Kohichi Takada, Kazuyuki Murase, Hiroki Sakamoto, Naotaka Hayasaka, Kazuma Ishikawa, Yuki Ikeda, Makoto Yoshida, Satoshi Iyama, Ko Kobayashi, Tetsuya Shindo, Shintaro Sugita, Koji Miyanishi, Masayoshi Kobune, Naoya Masumori, Junji Kato

“…Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. …”
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Recent advances in functional assays of WRKY transcription factors in plant immunity against pathogens by Wenjing Wang, Haihui Cao, Jiahao Wang, Hongbo Zhang

“…Plant signaling pathways or components involved in the regulatory network of WRKY-mediated plant immunity mainly involve the action of phytohormones, MAPKs (Mitogen-activated protein kinases), and other transcription factors. The interaction of WRKY TFs with these factors during pathogen resistance was discussed in this article, which may contribute to understanding the mechanisms of WRKY transcription factors in plant immunity.…”
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IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells by Katie B. Shannon

“…IQGAPs perform their myriad functions through association with a large number of proteins including filamentous actin (F-actin), GTPases, calcium-binding proteins, microtubule binding proteins, kinases, and receptors. The focus of this paper is on recent studies describing new binding partners, mechanisms of regulation, and biochemical and physiological functions of IQGAPs in yeast, amoeba, and mammalian cells.…”
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NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis by Shin Maeda

“…JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. …”
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The Role of Decorin in Autoimmune and Inflammatory Diseases by Yuanji Dong, Jixin Zhong, Lingli Dong

“…Decorin is involved in an extensive signaling network and can interact with other extracellular matrix components, growth factors, receptor tyrosine kinases, and various proteases. Decorin has been shown to be involved in wound repair, cell cycle, angiogenesis, tumor metastasis, and autophagy. …”
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Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription by Sonal Mohan Manohar, Kalpana Sanjay Joshi

“…Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events during colorectal carcinogenesis. …”
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Novel Homozygous TTI2 Variant Causing Autosomal Recessive Syndromic Intellectual Disability and Primary Microcephaly from Pakistan: A Case Report (Exome Report) by Zul Qarnain, Fatima Khan, Fizza Akbar, Salman Kirmani

“…TTI2 encodes a regulator of DNA damage response and helps maintain steady levels of the PIKK family of protein kinases. No disease-causing variants in other genes potentially linked to his clinical presentation were identified. …”
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Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway by Sang-Hoon Lee, Sung-Hwan Eom, Na-Young Yoon, Moon-Moo Kim, Yong-Xin Li, Sang Keun Ha, Se-Kwon Kim

“…Moreover, FF reduced the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs). These results strongly suggest that the inhibitory effects of fucofuroeckol-A from E. bicyclis on LPS-induced NO and PGE2 production might be due to the suppression of the NF-κB and MAPK signaling pathway.…”
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Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies by Junko Okabe-Kado, Takashi Kasukabe, Yasuhiko Kaneko

“…The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways. …”
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Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes by Gina Manda, Alexandru-Ionel Checherita, Maria Victoria Comanescu, Mihail Eugen Hinescu

“…Main topics this review is addressing are biomarkers of oxidative stress in diabetic nephropathy, the sources of reactive oxygen species (mitochondria, NADPH-oxidases, hyperglycemia, and inflammation), and the redox-sensitive signaling networks (protein kinases, transcription factors, and epigenetic regulators). …”
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Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Numerous mechanisms that include overexpression of alternate receptor tyrosine kinases and/or loss of critical tumor suppressors have been proposed in the last several years to elucidate trastuzumab resistance. …”
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A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow” by Deanna M. Minich

“…These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. …”
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FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN by Krishnakumar Kizhatil, Graham M. Clark, Daniel K. Sunderland, Aakriti Bhandari, Logan J. Horbal, Revathi Balasubramanian, Simon W. M. John

“…We hypothesize that mechano-responsive phosphorylation of the cell adhesion molecule VE-CADHERIN (CDH5) in SECs, by FYN and possibly other SRC family kinases, regulates adherens junction (AJ) permeability to AQH in response to IOP. …”
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Positively charged specificity site in cyclin B1 is essential for mitotic fidelity by Christian Heinzle, Anna Höfler, Jun Yu, Peter Heid, Nora Kremer, Rebecca Schunk, Florian Stengel, Tanja Bange, Andreas Boland, Thomas U. Mayer

“…Abstract Phosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell cycle progression. …”
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Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications by Soroush Fotouhi, Aida Yavari, Amir Reza Bagheri, Vahid Reza Askari, Yazdan Gholami, Vafa Baradaran Rahimi

“…They also possessed antioxidant and anti-inflammatory impacts through regulating mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-κB), and Nrf2 signaling pathways. …”
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Myeloid-Related Protein Activity in Rheumatoid Arthritis by Charles J. Malemud

“…MRPs also activate the signal transduction pathway principally involving the stress-activated/mitogen-activated protein kinases. MRP-8/MRP-14 also increased nitric oxide synthesis. …”
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Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice by Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J. Zhu, Y. Tony Ip, Xu Wu, Junhao Mao

“…Here, we find that removal of the core Hippo kinases Lats1/2 or activation of YAP in adult intestinal smooth muscle layers has largely no effect; however, Hippo-YAP signaling in the niche-forming Gli1+ mesenchymal cells plays intrinsic roles in regulating intestinal homeostasis. …”
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