JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease by Darya Farhoomand Aksoy, Rahime Aksoy, Sevim Gönen, Ümit Ölmez

“…T cells are crucial in the pathogenesis of BD. Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increase the risk of developing some autoimmune diseases. …”
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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Although the combination of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) with ganciclovir (GCV) has been shown as a promising suicide gene treatment strategy for glioma, the almost immunodepressive dose of GCV required for its adequate in vivo efficacy has hampered its further clinical application. …”
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Exploring adherence in patients with advanced breast cancer: focus on CDK4/6 inhibitors by Baković Matea, Bago Martina, Benić Lucija, Krajinović Magdalena, Silovski Tajana, Plavetić Natalija Dedić, Turković Lu, Sertić Miranda, Hadžiabdić Maja Ortner

“…Our aim was to explore the adherence to oral anticancer medications (OAM) in women with advanced breast cancer, focusing on cyclin-dependent kinase 4 and 6 inhibitors (CDKI), and identify factors associated with the adherence. …”
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Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability by Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu

“…The hypothalamus and hippocampus of each group modelling PMS displayed the following features: decreased expression of Ulip2, tubulin beta chain 15, α actin, and interleukin 1 receptor accessory protein; increased expression of kappa-B motif-binding phosphoprotein; decreased expression of hydrolase at the end of ubiquitin carboxy, albumin, and aldolase protein; and increased expression of M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, and calcium-binding protein. …”
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Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study by Geke Zhu, Han Zhou, Wanying Wang, Yongbo Ma, Xiangtao Nie, Wenjing Qi, Lei Hao, Xiuming Guo

“…During the 8-week follow-up, in GMG patients, whether positive for acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK) antibodies, the overall efficacy was significant. …”
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Association of Septic Shock with Mortality in Hospitalized COVID-19 Patients in Wuhan, China by Shaoqiu Chen, Zitong Gao, Ling Hu, Yi Zuo, Yuanyuan Fu, Meilin Wei, Emory Zitello, Gang Huang, Youping Deng

“…These eight factors included disease severity (HR = 15, p<0.001), age > 65 years (HR = 2.6, p=0.012), temperature > 39.1°C (HR = 2.9, p=0.047), white blood cell count > 10 × 10⁹ (HR = 6.9, p<0.001), neutrophil count > 75 × 10⁹ (HR = 2.4, p=0.022), creatine kinase > 5 U/L (HR = 1.8, p=0.042), glucose > 6.1 mmol/L (HR = 7, p<0.001), and lactate > 2 mmol/L (HR = 22, p<0.001). …”
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Uncovering the molecular mechanisms of Acer fabri in adjusting to low-temperature stress through integrated physiological and transcriptomic analysis by Gongwei Chen, Dandan Zhang, Fengyuan Chen, Yixiao Zhou, Hongyu Cai, Heng Gu, Yuanzheng Yue, Lianggui Wang, Guohua Liu

“…Differentially expressed genes (DEGs) were significantly enriched in metabolic pathways, phytohormone signaling, and plant mitogen-activated protein kinase (MAPK) signaling pathways. Moreover, the analysis of gene co-expression networks, specifically weighted gene co-expression network analysis (WGCNA), indicates that Af0048792 and Af0026061 could be significant in the response to stress from low temperatures. …”
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Comprehensive analysis of proteomic and biochemical responses of Daphnia magna to short-term exposure to polystyrene microplastic particles by Young Sang Kwon, Chang-Beom Park, Seung-Min Lee, Jin-Woo Park, Yeong-Jin Kim, Jong-Hwan Kim, Jong-Su Seo

“…The upregulation of endocytosis-related proteins, including caveolin-1 (CAV1) and phosphatidylinositol-4-phosphate 5-kinase (PIP5K), highlights their role in actively internalizing and compartmentalizing MP, potentially as a protective mechanism against oxidative damage. …”
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Oxidative stress in diabetes mellitus and its complications: From pathophysiology to therapeutic strategies by Xingyu Chen, Na Xie, Lixiang Feng, Yujing Huang, Yuyao Wu, Huili Zhu, Jing Tang, Yuanyuan Zhang, Ting Gao

“…Hyperglycemia and hyperlipemia boost excessive reactive oxygen species generation by elevated mitochondrial respiration, increased nicotinamide adenine dinucleotide phosphate oxidase activity, and enhanced pro-oxidative processes, including protein kinase C pathways, hexosamine, polyol, and advanced glycation endproducts, which exacerbate oxidative stress. …”
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A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in <i>Komagataella phaffii</i> by Albert Fina, Sílvia Àvila-Cabré, Enrique Vázquez-Pereira, Joan Albiol, Pau Ferrer

“…Co-overexpression of genes encoding a NADPH-dependent redox shuttle from <i>Saccharomyces cerevisiae</i> (<i>IDP2</i>/<i>IDP3</i>) significantly increased 3-HP yields across all substrates, whereas peroxisomal targeting of the <i>S. cerevisiae</i> NADH kinase Pos5 failed to improve 3-HP production. This study highlights the potential of using peroxisomal 3-HP production as a biosensor for evaluating peroxisomal acetyl-CoA and NAPDH availability by simply quantifying 3-HP, demonstrating its potential for peroxisome-based metabolic engineering in yeast.…”
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Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation by Aleksandra Jankovic, Aleksandra Korac, Biljana Buzadzic, Vesna Otasevic, Ana Stancic, Milica Vucetic, Milica Markelic, Ksenija Velickovic, Igor Golic, Bato Korac

“…The expression profiles of adiponectin, resistin, 5′-AMP-activated protein kinase α (AMPKα), hypoxia-inducible factor-1α (HIF-1α), and key enzymes of glucose and fatty acid metabolism and oxidative phosphorylation in rat retroperitoneal white adipose tissue (RpWAT) during 45-day cold acclimation were examined. …”
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Effects of <italic>Cistanche Deserticola</italic> on Behavior and Expression of GSK-3β in Hippocampus of Rat Model of Parkinson's Disease by Shasha YANG, Wei QIN, Shiya CHEN, Jing CAI

“…Objective:To observe the effects of <italic>cistanche deserticola</italic> on the behavior of rat model of Parkinson's disease (PD) and expression of glycogen synthase kinase-3 beta (GSK-3β) in hippocampus, levels of β-catenin protein and its phosphorylation, and explore its mechanism in treating Parkinson's disease.Methods:Fifty male rats were randomly divided into six groups (normal group, model group, sham operation group, low dose group, middle dose group and high dose group). …”
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The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway by Sen Wang, Zhengwei Duan, Zihua Li, Dong Yang, Hengli Lu, Yiwei Zhang, Yuesong Fu, Yonghao Guan, Guodong Li, Feng Qian, Tianyang Xu

“…Abstract Background The study aimed to explore whether Miya (MY), a kind of Clostridium butyricum, regulated osteoarthritis (OA) progression through adenosine 5’-monophosphate-activated protein kinase (AMPK) pathway. Methods The OA rats were orally given MY daily for 4 weeks and were intramuscularly injected with AMPK inhibitor once a week for 4 weeks. …”
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Human Platelets Take up Anti-VEGF Agents by B. Sobolewska, B. Fehrenbacher, P. Münzer, H. Kalbacher, S. Geue, Konstantinos Stellos, M. Schaller, F. Ziemssen

“…The role of actin filaments and clathrin-coated vesicles in the transport of ranibizumab, aflibercept, and bevacizumab was evaluated by two pharmacologic inhibitors: staurosporine (protein kinase C inhibitor) and cytochalasin D. Results. All three anti-VEGF agents were taken up by platelets and colocalized with VEGF. …”
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Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…The primary aim was to compare clinical outcomes and therapeutic responses between patients treated with high-dose versus low-dose methylprednisolone.ResultsPatients receiving an initial high-dose intravenous methylprednisolone (1 g/day) exhibited a more rapid reduction in myocardial injury markers, including troponin I/T (cTnI/T), creatine kinase (CK), and N-terminal pro b-type natriuretic peptide (NT-proBNP), compared to those receiving lower doses. …”
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Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism by Ying-hao Pei, Jiao Chen, Liang Xie, Xiao-min Cai, Run-Hua Yang, Xing Wang, Jian-bin Gong

“…Prereperfusion administration of HT was associated with a significantly smaller area of myocardial infarction and remarkably decreased level of myocardial apoptosis and necrosis, as evidenced by a lower apoptotic index, reduced cleaved caspase-3, and the serum activities of lactate dehydrogenase and creatinine kinase MB. Moreover, HT also attenuated the impairment of cardiac systolic function. …”
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Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage by Ning Du, Boxiang Zhang, Yunfeng Zhang

“…And the antitumor effect of bovine pox virus-associated kinase 1 (VRK1) is becoming a hot research topic. …”
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Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib by Jingjing Xiang, Liangliang Cai, Qin Wang, Yonghong Zhu, Yong Han

“…BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer. …”
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Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis by Meng Wang, Licheng Wang, Shusheng Wu, Dongsheng Zhou, Xianming Wang

“…Kaplan-Meier survival curves indicated that high expression of cyclin-dependent kinase (CDK1), cyclin B1 (CCNB1), cyclin B2 (CCNB2), MAD2 mitotic arrest deficient-like 1 (MAD2L1), and topoisomerase IIα (TOP2A) predicted poor overall survival in HCC patients (all log-rank P<0.01). …”
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Long-Term Salinity-Responsive Transcriptome in Advanced Breeding Lines of Tomato by Monther T. Sadder, Ahmad Abdelrahim Mohamed Ali, Abdullah A. Alsadon, Mahmoud A. Wahb-Allah

“…For example, 22 paralogs of <i>CBL-interacting kinase</i> genes were more up-regulated in L56 than in L45. …”
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