Discovery and Evaluation of Polymorphisms in the and Promoter Regions for Risk of Korean Lung Cancer by Jae Sook Sung, Kyong Hwa Park, Seung Tae Kim, Yeul Hong Kim

“…There are 3 mammalian isoforms of this serine/threonine protein kinase-AKT1, AKT2, and AKT3-showing a broad tissue distribution. …”
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HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition by Azim Hossain, Jason M. God, Faisal F. Y. Radwan, Shereen Amria, Dan Zhao, Jennifer R. Bethard, Azizul Haque

“…Treatment of BL with broystatin-1, a potent modulator of protein kinase C, led to significant improvement of functional class II Ag presentation in BL. …”
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PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists by Neerupma Silswal, Nikhil K. Parelkar, Michael J. Wacker, Mostafa Badr, Jon Andresen

“…In the MCA, dilations were inhibited by the protein kinase C (PKC) activator, phorbol 12,13-dibutyrate, and also by ODQ. …”
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Maternal prediabetes as a risk factor of preeclampsia and placental dysfunction in pregnant female Sprague-Dawley rats by Aneliswe Siboto, Asiphaphola Ludidi, Ntethelelo Sibiya, Andile Khathi, Phikelelani Ngubane

“…Placental vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) mRNA expression were measured terminally. …”
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IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…Treatment with a Janus kinase (JAK) pathway inhibitor, however, partially reduced the expression of these proteins and attenuated myocardial injury. …”
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Flavonoid Naringenin: A Potential Immunomodulator for Chlamydia trachomatis Inflammation by Abebayehu N. Yilma, Shree R. Singh, Lisa Morici, Vida A. Dennis

“…Pathway-specific inhibition studies disclosed that p38 mitogen-activated-protein kinase (MAPK) is involved in the production of inflammatory mediators by infected macrophages. …”
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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation by Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C. Hay, Stuart J. Forbes, Victoria L. Gadd, Neil O. Carragher

“…This work has identified small-molecule Src family kinase inhibitors that promote the differentiation of HepaRG cells toward a hepatocyte-like lineage as well as primary human hepatic progenitor cells toward a hepatocyte-like phenotype in vitro. …”
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Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin by J Blahova, P Mikula, P Marsalek, Z Svobodova

“…The exposure to the highest two concentrations resulted in significant changes in plasma indices such as glucose (only group 100 μg/l), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), lipase, creatine kinase (CK), amylase as well as butyrylcholinesterase (BChE). …”
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Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells by Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, Osamu Shido

“…EPA increased the mRNA levels of p21cip1 and p27kip1, a cyclin-dependent kinase inhibitor, which indicated that EPA induced cell cycle arrest. …”
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Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…Further, the top 2 moieties – Djh1 and Djh2 were selected after MMGBSA analysis and target selectivity prediction towards kinase. Further induced fit docking (IFD) analysis, DFT analysis, and MD simulation were employed to establish that – Djh1 and Djh2 could act as potential hit molecules for selective inhibition of PI3Kα. …”
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Changing of expression actinbinding proteins in the kidney under dehydration by I. I. Khegay

“…The most probable molecular mechanism of changing the expression of the genes for alpha-actinin and tropomyosin is transduction of the V2-mediated vasopressin hormonal signal to protein kinase A, phosphorylation of the cAMPresponsible transcriptional factor CREB, and nuclear CREB interaction with gene CRE sites sensitive to it.…”
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Fungal genomes: suffering with functional annotation errors by Tapan Kumar Mohanta, Ahmed Al-Harrasi

“…However, InterproScan analysis indicated that none of the protein sequences annotated as “calcium dependent protein kinase” were found to encode calcium binding EF-hands at the regulatory domain. …”
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Cost-effectiveness of Ruxolitinib vs Best Available Therapy in the Treatment of Myelofibrosis in Spain by María Teresa Gómez-Casares, Juan Carlos Hernández-Boluda, Antonio Jiménez-Velasco, Joaquin Martínez-López, María Giovanna Ferrario, Irmina Gozalbo, Joana Gostkorzewicz, Rudi Subirá

“…Identification of the Janus Kinase (JAK) gene mutations inaugurated a new era in the targeted therapy of myeloproliferative diseases. …”
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An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene by Fayeza Sadia Laskar, Md. Nazmul Islam Bappy, Md. Sowrov Hossain, Zenifer Alam, Dilruba Afrin, Sudeb Saha, Kazi Md. Ali Zinnah

“…Mesenchymal–epithelial transition (MET) factor is a proto-oncogene encoding tyrosine kinase receptor with hepatocyte growth factor (HGF) or scatter factor (SF). …”
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Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis by Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong

“…Our study revealed that these DEGs were primarily associated with cell cycle arrest, p53-mediated signal transduction, drug response, and gland development, with molecular functions enriched in growth factor binding, collagen binding, and receptor protein kinase activity. GSEA revealed that the co-DEGs were primarily associated with immune and inflammatory pathways. …”
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Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy by Ninna Aggerholm-Pedersen, Christina Demuth, Akmal Safwat, Peter Meldgaard, Moustapha Kassem, Boe Sandahl Sorensen

“…An immortalised nontransformed human stromal (mesenchymal) stem cell line hMSC-TERT4 and a transformed cell line hMSC-TERT20-CE8, known to form sarcoma-like tumours when implanted in immune-deficient mice, were used as models. Receptor tyrosine kinase (RTK) activation was analysed by RTK arrays and cellular viability after tyrosine kinases inhibitor (TKI) treatment with or without doxorubicin was assessed by MTS assay. …”
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The Hippo Signaling Pathway Manipulates Cellular Senescence by Chiharu Miyajima, Mai Nagasaka, Hiromasa Aoki, Kohki Toriuchi, Shogo Yamanaka, Sakura Hashiguchi, Daisuke Morishita, Mineyoshi Aoyama, Hidetoshi Hayashi, Yasumichi Inoue

“…The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. …”
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Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity by Wenlong Liu, Qingxiang Zeng, Yanqiu Chen, Ren Zhong Luo

“…Leptin and OPN mediated migration and activation of eosinophil through phosphatidylinositol-3-OH kinase (PI3K) pathway. Obese AR mice presented with more severe eosinophilia and symptoms compared with nonobese AR mice or control mice. …”
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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. by Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng

“…MVA infection of cDCs triggers phosphorylation of TBK1 (Tank-binding kinase 1) and IRF3, which is abolished in the absence of cGAS and STING. …”
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Real-world assessment to estimate multiple attributes related to treatment cost driver for mantle cell lymphoma in Japan by econometric modeling by Saaya Tsutsué, Shinichi Makita, Hiroya Asou, Anila Mathew, Yuki Kado, Koki Idehara, Seok-Won Kim, Dilinuer Ainiwaer

“…SEM analysis revealed Bruton tyrosine kinase inhibitor-based treatment as a cost driver (β: 0.398 [0.340; 0.457], p < 0.001). …”
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