The Impact of Bioactive Lipids on Cardiovascular Development by Alexander Kleger, Stefan Liebau, Qiong Lin, Götz von Wichert, Thomas Seufferlein

“…LPA stimulates the clonal expansion of neurospheres from neural stem/progenitor cells and induces c-fos via activation of mitogen- and stress-activated protein kinase 1 (MSK1) in ES cells. S1P acts on hematopoietic progenitor cells as a chemotactic factor and has also been found to be critical for cardiac and skeletal muscle regeneration. …”
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Neurotensin is a Versatile Modulator of In Vitro Human Pancreatic Ductal Adenocarcinoma Cell (PDAC) Migration by Tatjana Mijatovic, Philippe Gailly, Véronique Mathieu, Nancy De Nève, Paul Yeaton, Robert Kiss, Christine Decaestecker

“…While the NT effects on individually migrating PDACs were mediated at least through the EGFR/ERK signaling pathways, those on collectively migrating PDACs appeared highly dependent on the PI 3-kinase pathway. Conclusion: This study strongly suggests the involvement of neurotensin in the modulation of human PDAC migration.…”
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Exploring the association between BDNF related signaling pathways and depression: A literature review by Yuchen Fan, Xinchi Luan, Xuezhe Wang, Hongchi Li, Hongjiao Zhao, Sheng Li, Xiaoxuan Li, Zhenkang Qiu

“…At present, the pathogenesis of multiple depression is not fully clear, but its occurrence can be related to biological or environmental pathways, among which Brain-derived neurotrophic factor (BDNF) can unequivocally act on two downstream receptors, tyrosine kinase receptor (TrkB) and the p75 neurotrophin receptor (p75NTR), then affect the related signal pathways, affecting the occurrence and development of depression. …”
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Overexpression of a sorghum SnRK1βγ2 gene increases the biomass in Setaria viridis but not in rice by Chudamani Sharma Prakash, Lihua Wang, Qi Shen, Jieqin Li, Yi-Hong Wang

“…In this study, we demonstrated that sorghum SbSnRK1βγ2 (SbSNF4-2), the γ subunit of the sucrose non-fermenting 1 (SNF1)/SNF1-related protein kinase 1 (SnRK1) heterotrimeric complex, increased the plant height and biomass in Setaria viridis, a C4 relative of sorghum, but not in rice, a C3 relative, when overexpressed driven by the maize ubiquitin promoter. …”
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Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…Exercise significantly upregulated phosphoinositide 3 kinase (PI3K) docking site phosphorylation and downregulated the negative IRS1 phosphorylations thereby increasing the glucose transporter (GLUT) expressions and reducing the lactate accumulation. …”
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Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Gene... by Elena V. Tchetina, Karina A. Maslova, Mikhail Y. Krylov, Valery A. Myakotkin

“…OP registered by low BMD indices in late postmenopausal patients was associated with a significant upregulation of autophagy protein ULK1, cyclin-dependent kinase inhibitor p21, and metalloproteinase MMP-9 gene expression in the blood compared to the healthy controls and in a significant downregulation of mTOR (mammalian target of rapamycin), RUNX2, and ALPL gene expression, while expression of cathepsin K, caspase-3, transforming growth factor (TGF)β1, interleukin- (IL-) 1β, and tumor necrosis factor α (TNFα) was not significantly affected. …”
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Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy by Zhuomiao Lin, Meiqing Yang, Xihui Yu, Guozhu Tan, Jiahong Zhong

“…Ponatinib, a third-generation tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia, was found to improve metabolic disorders in mice. …”
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Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia by Michael Loke, DO, Vishal Sehgal, MD, Niraj Gupta, MD

“…Background/Objective: Alpelisib is a phosphatidylinositol 3-kinase inhibitor used to treat certain hormone therapy resistant breast cancers that can cause hyperglycemia through inhibition of the insulin signaling cascade. …”
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Enitociclib, a selective CDK9 inhibitor: in vitro and in vivo preclinical studies in multiple myeloma by Son Tran, Patrick Sipila, Melanie M. Frigault, Beatrix Stelte-Ludwig, Amy J. Johnson, Joseph Birkett, Raquel Izumi, Ahmed Hamdy, Ranjan Maity, Nizar J. Bahlis, Paola Neri, Aru Narendran

“…Enitociclib, a cyclin-dependent kinase 9–specific small-molecule inhibitor, was found to be highly effective in decreasing cell viability and inducing apoptosis in 4 MM cell lines. …”
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STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells by Xiangyu Wang, Fengmian Wang, Zhi-Gang Zhang, Xiao-Mei Yang, Rong Zhang

“…Serine/threonine protein kinase-3 (STK3) is a critical molecule of the Hippo pathway but little is known about its biological functions in the ovarian cancer development. …”
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. …”
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Construction of AMPK-related circRNA network in mouse myocardial ischemia–reperfusion injury model by Yang Song, Yi Zhao, Xiaodi Zhang, Cheng Cheng, Haidong Yan, Daxing Liu, Dengshen Zhang

“…Abstract Objective To screen Myocardial ischemia–reperfusion Injury in mice. adenosine monophate-activatedprotein kinase (AMPK) -related differentially expressed circularRNA (circRNA) in MIRI model, Ampk-related circRNA network was drawn to provide possible ideas for the prevention and treatment of MIRI. …”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. …”
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Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice by Yanyan Zhang, Yaxi Du, Hong Yu, Yongchun Zhou, Feng Ge

“…Rhabdomyolysis was monitored using creatine kinase (CK) level. Oxidative stress was determined using kidney tissue glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) levels. …”
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Features of diagnosis and treatment of gastrointestinal stromal tumors by N. I. Bogomolov, T. V. Burdinskaya, M. A. Goncharova, A. G. Goncharov, N. N. Tomskikh

“…Targeted therapy by tyrosine kinase inhibitors was carried out for 14 patients. …”
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Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role. by Silvana Arrighi, Giampaolo Bosi, Debora Groppetti, Fausto Cremonesi

“…Cryosections of normal canine bladder and urethra were immunofluorescently labelled with c-kit, a transmembrane, tyrosine kinase growth factor receptor, known to be expressed on the interstitial cells of Cajal (ICCs) of the gut. …”
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Impact of Hemoglobin, Leucocyte and Thrombocyte Levels at Diagnosis on the Survival Outcomes of Chronic Myeloid Leukemia Patients by Taha Ulutan Kars, Atakan Tekinalp, Rafiye Ciftciler, Sinan Demircioğlu

“…Background:Since the development of tyrosine kinase inhibitors (TKIs), the prognosis for chronic myeloid leukemia (CML) has significantly improved. …”
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Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei by Haitao Fan, Xin Zhang, Yanan Yin, Lefei Jiao

“…The gene expression of cellular energy sensor AMP-activated protein kinase was up-regulated in muscle and hepatopancreas. …”
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Isolated Central Nervous System Infiltrated and Progressed to Acute Myeloid Leukemia from Chronic Myeloid Leukemia with e1a3 BCR-ABL1 Transcript: A Rare Case Report and Literature... by Qiang X, Wen Q, Li J, Chen S, Tao T, Zhang H, Wang P, Peng X, Feng Y, Zhang X

“…Following initial diagnosis, the patient was treated with the tyrosine kinase inhibitor (TKI) Flumatinib. During the treatment, although the FCM-MRD of the bone marrow kept negative, the e1a3 expression detected by PCR always remained positive. …”
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Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice by Yong Xie, Yi Zhang, Zebin Guo, Hongliang Zeng, Baodong Zheng

“…Further investigation indicated that NPA could inhibit IR by restoring the insulin receptor substrate-1 (IRS-1) and suppressing the expression of c-Jun N-terminal kinase (JNK) phosphorylation. The present results supported the view that the pathogenesis of NAFLD was complex with inflammation, together with increasing serum glucose and IR. …”
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