Rare skin adverse reactions induced by osimertinib: a case report and literature review by Ye Zhang, Mingzhu Ling, Min Wang, Ye Chen, Liting Zhang

“…Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of EGFR mutation-positive advanced non-small cell lung cancer. …”
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Adverse Health Effects of the Long-Term Simultaneous Exposure to Arsenic and Particulate Matter in a Murine Model by Cesar Rivas-Santiago, Maria Gallegos-Bañuelos, Irving Trejo-Ramos, Nancy Solís-Torres, Raúl Quintana-Belmares, Noé Macías-Segura, Héctor Gutiérrez-Bañuelos, Lorena Troncoso-Vazquez, Bruno Rivas-Santiago, Irma Gonzalez-Curiel

“…The levels of creatine kinase, CK-MB, and lactate dehydrogenase increased in experimental groups. …”
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Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson’s Disease in Taiwan by Kuo-Hsuan Chang, Chiung-Mei Chen, Yi-Chun Chen, Hon-Chung Fung, Yih-Ru Wu

“…Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. …”
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Evaluation of some laboratory data in traumatic dogs by Semih Altan, Fahrettin Alkan, Yılmaz Koç

“…The obtained blood samples were analyzed for hematology, blood gas, serum biochemistry [alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), Phosphorus (P), cholesterol (Chol), creatinine (Crea), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), total protein (TP), triglyceride (Trig), blood urea nitrogen (BUN)] and thiobarbutyric acid reactive substance (TBARs) values.…”
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Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4 by Qianjie Yang, Kuangqi Chen, Siyi Chen, Yinhao Wang, Yutong Xia, Jinbo Chen, Ye Shen

“…Reactive oxygen species-mediated damage caused by BL upregulated ITGB4 expression, promoting cell migration and EMT through the extracellular signal-regulated kinase /Snail pathway.…”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…The most promising neuroprotective investigative priorities will involve disease-modifying trials of the safest agents alone or in combination to capture salutary effects on H3 histone deacetylase, gene transcription, glycogen synthase kinase-3, α-synuclein, reactive oxygen species (ROS), reactive nitrogen species (RNS), apoptosis, inflammation, and trophic factors including GDNF and BDNF.…”
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TOM1L Is Involved in a Novel Signaling Pathway Important for the IL-2 Production in Jurkat T Cells Stimulated by CD3/CD28 CoLigation by Ahmed Elmarghani, Hanan Abuabaid, Peter Kjellen

“…The ability of TOM1L to activate Fyn was further shown in a kinase assay using angiotensin II as a substrate. …”
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Short-term high-fat diet post-ACLT surgery activates chondrocyte AMPK pathway and slows articular cartilage degeneration in rats by Hongri Ruan, Tingting Zhu, Tianwen Ma, Yun Liu, Jiasan Zheng

“…Notably, HFD significantly enhances AMP-activated protein kinase (AMPK) phosphorylation in cartilage. In vitro experiments reveal that low concentrations of FFAs stimulate chondrocyte proliferation and energy metabolism, whereas AMPK inhibition leads to elevated expression of inflammatory mediators and ECM-degrading enzymes in chondrocytes. …”
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When herpes zoster is not herpes: A case of statin-induced myopathy complicated by drug allergies by Hira Khalid Kareem, Muhammad Fawad Ashraf, Muhammad Shehryar, Hafsa Fayyaz, Shreyas Patil

“…This case report discusses a 69-year-old female with multiple comorbidities, including smoldering multiple myeloma, who presented with myalgias and a vesicular rash initially suspected to be herpes zoster due to her immunocompromised status. Elevated creatine kinase (CK) levels were noted (>9000 U/L) while the patient was on high-dose atorvastatin. …”
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Visfatin Amplifies Cardiac Inflammation and Aggravates Cardiac Injury via the NF-κB p65 Signaling Pathway in LPS-Treated Mice by Yewen Hu, Nan Wu, Weiping Du, Shuangshuang Wang, Jian Wang, Chaoxia Zhang, Xiaomin Chen, Caijie Shen

“…In septic mice, pretreatment with visfatin reduced the survival rate, worsened cardiac dysfunction, and increased the expression of cardiac injury markers, including creatine kinase myocardial bound (CK-MB) and lactate dehydrogenase (LDH). …”
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Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes by Michelle A. Clark, Chinh Nguyen, Hieu Tran

“…Previously, we showed that Ang II and Ang III induced mitogen-activated protein (MAP) kinases ERK1/2 and stress-activated protein kinase/Jun-terminal kinases (SAPK/JNK) phosphorylation in cultured rat astrocytes. …”
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The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally. by Dan M Park, Md Sohail Akhtar, Aseem Z Ansari, Robert Landick, Patricia J Kiley

“…Here we provide new mechanistic insight into how the balance between reduced and oxidized electron carriers is regulated at the level of gene expression by mapping the regulon of the response regulator ArcA from Escherichia coli, which responds to the quinone/quinol redox couple via its membrane-bound sensor kinase, ArcB. Our genome-wide analysis reveals that ArcA reprograms metabolism under anaerobic conditions such that carbon oxidation pathways that recycle redox carriers via respiration are transcriptionally repressed by ArcA. …”
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A Case Report of EGFR-TKIs Resistant Secondary MET Gene Amplified 
Lung Squamous Cell Carcinoma and Literature Review by Yalan LIU, Peng CHEN, Xinfu LIU

“…At present, some selective tyrosine kinase inhibitors (TKIs) of MET has been approved for non-small cell lung cancer with MET gene 14 exon skipping mutation, such as Glumetinib, Savolitinib, Tepotinib, Capmatinib, etc. …”
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Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells by Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai

“…In this study, we identify that LI0758 can be secreted by the Yersinia T3SS, which suppresses yeast growth and activates mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathway in mammalian cells. …”
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PLASMABLASTIC LYMPHOMA. A STATE-OF-THE-ART REVIEW (1) by Michele Bibas

“…PBL must be distinguished from other B-cell malignancies that lack the CD20 marker, including primary effusion lymphoma, anaplastic lymphoma kinase-positive large B-cell lymphoma, and large B-cell lymphoma (LBCL). …”
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The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis by Mario Pezzi, Silvia Renda, Anna Maria Giglio, Anna Maria Scozzafava, Simona Paola Tiburzi, Patrizia Casella, Fabrizio Iannelli, Mario Verre

“…During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. …”
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Diabetic Muscle Infarction: A Rare Cause of Acute Limb Pain in Dialysis Patients by G. De Vlieger, B. Bammens, F. Claus, R. Vos, K. Claes

“…Biochemical blood analyses show an elevated C-reactive protein, but creatine kinase is often normal. Diagnosis can be made on clinical presentation and imaging, with magnetic resonance imaging as the gold standard. …”
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PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways by Julian Müller, Florian P. Bayer, Mathias Wilhelm, Maximilian G. Schuh, Bernhard Kuster, Matthew The

“…Additionally, PTMNavigator automatically runs kinase and pathway enrichment algorithms whose results are directly integrated into the visualization. …”
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Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise by Farnaz Seifi-skishahr, Arsalan Damirchi, Manoochehr Farjaminezhad, Parvin Babaei

“…The levels of cortisol, creatine kinase, plasma reduced glutathione to oxidized glutathione (GSH/GSSG), cysteine/cystine (Cys/CySS), and GSH/GSSG ratio in red blood cells (RBCs) were measured immediately and 10 and 30 min after exercise. …”
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Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model by Vijayan Raji, Chitra Loganathan, Thiyagarajan Ramesh, Palvannan Thayumanavan

“…The activity of various enzymes in the liver (hexokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1,6-phosphatase) and serum (creatine kinase) were normalized to that of control level. …”
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