PNMA1 is a novel immune modulator and therapeutic target in hepatocellular carcinoma linked to bile acid metabolism by Hongyu Chu, Yuezhan Shan, Chengwei Jiang, Yumin Zhong, Zijing Liu, Xuedong Fang, Zhaoying Yang

“…Notably, PNMA1 has emerged as a promising therapeutic target for tyrosine kinase inhibitors, as confirmed by reduced IC50 values and molecular docking. …”
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Inhibition of TNF-α and JNK Signaling Pathway Can Reduce Paclitaxel-Induced Apoptosis of Mouse Cardiomyocytes by Shuang Ren, Tianwen Huang, Danyan Ou, Luhuai Feng, Sisi Huang, Chaonan Zhou, Lianying Ge

“…Further analyses of the TNF-α level and the expression of Jun N-terminal kinase (JNK) and Bcl-2 family-related proteins in myocardial tissue were performed. …”
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Chlorogenic Acids Inhibit Adipogenesis: Implications of Wnt/β-Catenin Signaling Pathway by Mengting Liu, Jian Qin, Jing Cong, Yubin Yang

“…We investigate the effect of CGA in inhibiting adipogenesis and evaluate its role in modulating Wnt10b (wingless integration1 10b), β-catenin, glycogen synthase kinase-3β (GSK-3β), and peroxisome proliferator-activated receptor γ (PPAR-γ) involved in the Wnt (wingless integration1)/β-catenin signaling pathway. …”
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Activation of latent HIV during ART could improve recognition and elimination of infected cells by the immune system. Protein kinase C (PKC) isozymes increase HIV transcription and hence are potential latency reversal agents. …”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which are associated with pro-inflammatory responses and cell death. …”
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Novel approaches in myelofibrosis by Steffen Koschmieder

“…These drugs target transcription, nuclear export, survival pathways, or various intracellular pathways, ranging from JAK‐STAT signaling to PI3‐Kinase, TP53, PIM1, or S100A8/A9/toll‐like receptor pathways. …”
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Side-Alternating Vibration Training Improves Muscle Performance in a Patient with Late-Onset Pompe Disease by Aneal Khan, Barbara Ramage, Ion Robu, Laura Benard

“…There were no elevations in serum creatine kinase or lactate. This is the first report, to our knowledge, of a performance improvement in a patient with Pompe disease using SAVT.…”
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Determinants of Overall and Progression-Free Survival of Nigerian Patients with Philadelphia-Positive Chronic Myeloid Leukemia by Anthony A. Oyekunle, Rahman A. Bolarinwa, Adesola T. Oyelese, Lateef Salawu, Muheez A. Durosinmi

“…Objective. The tyrosine kinase inhibitors have markedly changed the disease course for patients with Ph+ and/or BCR-ABL1+ chronic myeloid leukemia (CML). …”
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Genetic polymorphisms of muscular fitness in young healthy men. by Tomas Venckunas, Hans Degens

“…Five of the studied polymorphisms (activin- and adreno-receptors, as well as myosine light chain kinase 1) in a group of one to three combined with body height, age and/or group explained up to 20.4% of the variation of muscle function. …”
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A Study of Inflammatory/Necrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation by Mariapaola Marino, Giuseppe Palmieri, Marco Peruzzi, Flavia Scuderi, Emanuela Bartoccioni

“…Serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and plasma creatin kinase (CK) were evaluated 1 hour preoperatively and 24 hours postoperatively. …”
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Reduced PKC α Activity Induces Senescent Phenotype in Erythrocytes by Rukmini B. Govekar, Poonam D. Kawle, Suresh H. Advani, Surekha M. Zingde

“…In this study, the role of protein kinase C (PKC) isoforms in the expression of these surface modifications was investigated. …”
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Consensus guidelines for the management of treatment-naïve chronic lymphocytic leukaemia in Singapore (2024) by Yeow Tee Goh, Yvonne Loh, Esther Chan, Yuh Shan Lee, Venkata Sreekanth Sampath, Daryl Tan, Shin Yeu Ong, Chandramouli Nagarajan

“…Due to the superior efficacy of targeted agents (Bruton's tyrosine kinase inhibitors [BTKis] and B-cell lymphoma 2 inhibitors [BCL2is]), sthese are favoured over standard chemotherapy or chemotherapy-immunotherapy, especially for patients with del(17p) or TP53 mutation, and less fit patients. …”
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Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro by Lina Zhao, Xianyu Zhang, Chunhai Zhang

“…We also measured the phosphorylation of extracellular signal-regulated kinase (ERK) in these cultures and found that methimazole could significantly inhibit the scratch-induced GFAP upregulation. …”
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Inhibition of myotube formation by platelet-derived growth factor subunit B in QM7 cells by Sarang Choi, Sangsu Shin

“…To investigate the inhibitory mechanisms of PDGFB on myogenic differentiation, the mRNA expression levels of various genes and the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2), both known to regulate muscle development and differentiation were compared. …”
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Current preeclampsia prediction model and biomarker by Anak Agung Ngurah Jaya Kusuma

“…Additionally, biomarkers like mean arterial pressure (MAP), UtA-PI, and the ratio of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) are employed to improve predictive accuracy. …”
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Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers by Ruohua Li, Cuixia Zhou, Kejun Ye, Haihui Chen, Mengjia Peng

“…Key differentially expressed genes included CRH(Corticotropin-Releasing Hormone), LEP(Leptin), PDK4(Pyruvate Dehydrogenase Kinase Isozyme 4), SPP1(Secreted Phosphoprotein 1), and SST(Somatostatin). …”
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An Insight of Vitamin E as Neuroprotective Agents by Hui-Min Yap, Kwan-Liang Lye

“…Vitamin E is known as a chain-breaking antioxidant that showed the capability to increase the viability of neuronal cells that had undergone glutamate injury by inhibiting glutamate-induced pp60 (c-Src) kinase activation. Vitamin E occurs in 8 forms, namely α-, β-, γ- and δ-tocopherols and α-, β-, γ-and δ-tocotrienols. …”
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Elucidating the Mechanisms of Acquired Palbociclib Resistance via Comprehensive Metabolomics Profiling by Lulu Yang, Yajun Yue, Zhendong Wang, You Jiang, Zhichao Xue, Yongzhuo Zhang

“…Palbociclib is a cyclin-dependent kinase 4/6 inhibitor and a commonly used antitumor drug. …”
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RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes by Elena Bevilacqua, Casey A. Frankenberger, Marsha Rich Rosner

“…By using a novel, interdisciplinary approach applied to the mechanism of action of the metastasis suppressor, Raf kinase inhibitory protein (RKIP), we identified a signaling pathway that suppresses invasion and metastasis through regulation of stroma-associated genes. …”
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