Multisystem Myotilinopathy, including Myopathy and Left Ventricular Noncompaction, due to the MYOT Variant c.179C>T by Josef Finsterer, Claudia Stöllberger, Matthias Hasun, Korbinian Riedhammer, Mathias Wagner

“…The patient is a 72-year-old male with a history of strabismus in childhood, asymptomatic creatine-kinase elevation since age 42 years, slowly progressive lower limb weakness since age 60 years, slowly progressive dysarthria and dysphagia since age 62 years, and recurrent episodes of arthralgias and myalgias since age 71 years. …”
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Analysis of acute lymphoblastic leukemia drug sensitivity by changes in impedance via stromal cell adherence. by Annie Luong, Fabio Cerignoli, Yama Abassi, Nora Heisterkamp, Hisham Abdel-Azim

“…This system was able to discriminate sensitivity of two relapsed Philadelphia chromosome (Ph) positive ALLs to four different targeted kinase inhibitors. Moreover, differences in sensitivity of two CRLF2-drivenBCP-ALL cell lines to ruxolitinib were also seen. …”
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Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants by Pankaj Dhonukshe

“…They uncover the PIN polarity generation mechanism and identified important roles of AGC kinases for polar PIN localization. AGC kinase family members PINOID, WAG1, and WAG2, belonging to the AGC-3 subclass predominantly influence the polar localization of PINs. …”
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A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil by Osman Zikrullah Sahin, Teslime Ayaz, Suleyman Yuce, Fatih Sumer, Serap Baydur Sahin

“…Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient’s renal function tests improved gradually. …”
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Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity by Peng Wang, Xin Li, Xuran Li, Weiwei Yang, Shun Yu

“…This was supported by the observations that phosphorylated α-syn oligomers entered neurons, rapidly increased accumulated thioflavin S-positive inclusions, and induced a series of metabolic changes that included activation of polo-like kinase 2, inhibition of glucocerebrosidase and protein phosphatase 2A, and reduction of ceramide levels, all of which have been shown to promote α-syn phosphorylation and aggregation. …”
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Exceptional Response of Metastatic Chromophobe Renal Cell Carcinoma to Vascular Endothelial Growth Factor (VEGF) Inhibitors: Should Increased VEGF-C Expression Be Used to Guide Tre... by Jacob W. Bruinius, Karl J. Dykema, Sabrina L. Noyes, Bin Tean Teh, Brian R. Lane

“…There is sparse literature demonstrating effective treatments for metastatic chromophobe renal cell carcinoma (ChRCC). The tyrosine kinase inhibitor (TKI) sunitinib selectively inhibits the VEGF pathway and it is a standard care for metastatic clear cell renal cell carcinoma (ccRCC), although data supporting its use in ChRCC is much more limited. …”
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Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population by Anthony S. Perry, Bungo Furusato, Raymond B. Nagle, Sourav Ghosh

“…Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. …”
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GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells by Fumiya Ito, Wakiko Iwata, Yoshihiro Adachi, Hiromi Sesaki, Miho Iijima

“…Further analysis revealed that GRHL2 upregulates the receptor tyrosine kinase HER3, and that HER3 knockdown similarly decreases the IC50 for erlotinib. …”
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p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation by Na Li, Zhaoyu Du, Yunxiang Li, Wenjing Xu, Yumei Yang, Haodong Peng, Tianxiang Song, Qihua Qin, Huining Lei, Jinlian Hua

“…Herein, we discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs (mESCs). p57 knockdown significantly stimulated the expressions of core pluripotency factors NANOG, OCT4, and SOX2, while p57 overexpression inhibited the expressions of these factors in mESCs. …”
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The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling by Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi

“…LFA1-dependent AMPK activation enhances LFA1 and LC3 clustering and adhesion. Inhibiting Mst1 kinase-mediated LC3 phosphorylation promoted LC3-mediated LFA1 recruitment to the contact surface through direct interaction with RAPL, uncovering an unprecedented integrin recruitment route. …”
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Delayed Presentation of Gluteal Compartment Syndrome: The Argument for Fasciotomy by John E. Lawrence, Duncan J. Cundall-Curry, Kuldeep K. Stohr

“…Blood tests revealed acute kidney injury with raised creatinine kinase and the patient was treated for rhabdomyolysis. …”
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CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE by Zhanyun Da, Liuxia Li, Jin Zhu, Zhifeng Gu, Bo You, Ying Shan, Si Shi

“…Western blot and immunofluorescence assay revealed that CXCL13 would lead to phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). However, the effect was weakened after the silence of CXCR5. …”
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Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout by Sara Comesaña, Mauro Chivite, Ayelén M. Blanco, María Alborja-Valado, Jessica Calo, Marta Conde-Sieira, José L. Soengas

“…In the second experiment, we evaluated in the hypothalamus and telencephalon the following: (1) the phosphorylation status of mTOR and its downstream effectors ribosomal protein S6 and p70 S6 kinase 1 (S6K1), (2) the abundance and phosphorylation status of transcription factors involved in appetite regulation, and (3) the mRNA levels of key neuropeptides associated with homeostatic regulation of feed intake in fish. …”
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人神经营养素-3 受体基因的扩增及其重组腺病毒载体的构建 by 王俊梅, 曾园山, 刘然义, 吴立志, 黄嘉凌, 黄必军, 黄文林

“…【目的】构建人神经营养素-3(neurotrophin-3,NT-3)受体(即酪氨酸蛋白激酶受体C, tyrosine protein kinase C, TrkC)基因重组的腺病毒表达载体。【方法】从人脑组织mRNA 中扩增TrkC 基因全长cDNA, 定向克隆于穿梭质粒pShuttle 中, 获得一个带有CMV 启动子的表达盒。…”
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Inflammatory Response Mechanisms Exacerbating Hypoxemia in Coexistent Pulmonary Fibrosis and Sleep Apnea by Ayodeji Adegunsoye, Jay Balachandran

“…Adipocytes may induce hypoxia inducible factor (HIF) 1α production; GERD is associated with increased levels of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and tumor necrosis factor alpha (TNF-α); pulmonary artery myocytes often exhibit increased cytosolic free Ca2+. Protein kinase C (PKC) mediated upregulation of TNF-α and IL-1β also occurs in the pulmonary arteries. …”
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Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer: Evolving Paradigms by Joelle El-Amm, Ashley Freeman, Nihar Patel, Jeanny B. Aragon-Ching

“…Other novel bone-targeted agents are currently in development, including the receptor tyrosine kinase inhibitors cabozantinib and dasatinib. Emerging therapeutics in mCRPC has resulted in great strides in preventing one of the most significant sources of complications of bone metastases.…”
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Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis by Toshihisa Ishikawa, Hiroshi Nakagawa, Yuichiro Hagiya, Naosuke Nonoguchi, Shin-ichi Miyatake, Toshihiko Kuroiwa

“…Since patients have demonstrated individual differences in their response to photodynamic therapy, transcriptional activation and/or genetic polymorphisms of the ABCG2 gene in cancer cells may affect patients' responses to photodynamic therapy. Protein kinase inhibitors, including imatinib mesylate and gefitinib, are suggested to potentially enhance the efficacy of photodynamic therapy by blocking ABCG2-mediated porphyrin efflux from cancer cells. …”
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Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…Here we report the application of repetitive PET-CT imaging with [ 18 F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ( 18 F-FEAU) in two nonhuman primates demonstrating that autologous polyclonal macaque T lymphocytes activated and transduced with a retroviral vector encoding for the sr39 mutant herpes simplex virus 1 thymidine kinase ( sr39HSV1-tk ) reporter gene can be detected after intravenous infusion in discrete lymphoid organs and in sites of inflammation. …”
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转移力不同的肺癌克隆细胞中nm23-H1基因产物NDPK 的表达 by 张　彬, 熊　敏, 韩安家, 梁英杰

“…【目的】比较转移抑制基因nm23-H1 表达产物核苷酸二磷酸激酶(nucleoside diphosphate kinase , NDPK)在转移力 不同的肺癌克隆株中的表达。【方法】通过单细胞克隆技术及裸鼠接种筛选出高转移及低转移的人肺巨细胞癌克隆细胞株及 高转移的人肺腺癌克隆细胞株, 用LSAB 免疫组化法检测nm23-H1 基因产物NDPK 的表达。…”
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The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. by Alessia Soldano, Zeynep Okray, Pavlina Janovska, Kateřina Tmejová, Elodie Reynaud, Annelies Claeys, Jiekun Yan, Zeynep Kalender Atak, Bart De Strooper, Jean-Maurice Dura, Vítězslav Bryja, Bassem A Hassan

“…Moreover, we show that APPL regulates PCP pathway activation by modulating the phosphorylation of the Wnt adaptor protein Dishevelled (Dsh) by Abelson kinase (Abl). Taken together our data suggest that APPL is the first example of a modulator of the Wnt-PCP pathway specifically required for axon outgrowth.…”
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