Evolution of copro-tests in active detection of colorectal cancer by V. I. Chissov, N. S. Sergeyeva, Ye. V. Zenkina, N. V. Marshrutina

“…Besides that, detection of the tumor-specific pyruvate kinase type М2 in feces (fTu M2-PK) also can be used in the screening programs for active detection of CRC, as it was shown in series of studies.Conclusion. …”
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Myoglobin Cast Nephropathy Diagnosed on Renal Biopsy in a Patient Treated for Malarial Infection by Ramya Varadarajan, Ashmi Patel, Haneen Salah, Neil Sutaria, Roberto Barrios, Luan Truong, Lillian Gaber, Ziad M. El-Zaatari

“…Myoglobin cast nephropathy occurs in cases of acute renal injury in which large amounts of myoglobin accumulate in the renal tubules, presenting as muscle pain, reddish-brown urine, and elevated creatine kinase levels. Our case describes a 60-year-old male who came to the emergency department with fevers, mild abdominal pain, and constitutional symptoms one day after returning to the United States from a trip to Nigeria. …”
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ATM in immunobiology: From lymphocyte development to cancer immunotherapy by Ji-Hoon Lee

“…Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Furthermore, the results show that activation of 5′AMP-activated protein kinase (AMPK) by metformin enhances cell autophagy in senescent hBMSCs. …”
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Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL by Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong

“…We hypothesized that inhibiting the IGF-1 receptor (IGF-1R) using NVP-AEW541, a small molecular weight tyrosine kinase inhibitor of the IGF-1R, could increase death receptor (DR)-mediated apoptosis in colon cancer cells.…”
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Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling by Jayalakshmi Krishnan, Sangdun Choi

“…In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-β, or cAMP analog 8-Br. …”
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Treatment of Liver Metastases in Patients with Neuroendocrine Tumors of Gastroesophageal and Pancreatic Origin by Ping Gu, Jennifer Wu, Elliot Newman, Franco Muggia

“…In patients with advanced pancreatic NET, randomized, placebo-controlled studies have recently demonstrated that treatment with the tyrosine kinase inhibitor sunitinib or with mTOR inhibitor everolimus is associated with improved progression-free survival. …”
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Two Sides of the Same Coin: TFIIH Complexes in Transcription and DNA Repair by Alexander Zhovmer, Valentyn Oksenych, Frédéric Coin

“…TFIIH is organized into a seven-subunit core associated with a three-subunit Cdk-activating kinase (CAK) module. TFIIH has roles in both transcription initiation and DNA repair. …”
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Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy by Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah

“…A common first-line therapy offered to qualifying patients includes ibrutinib, an oral covalent inhibitor of Bruton’s tyrosine kinase. Treatment of CLL with ibrutinib therapy is generally well tolerated; however, serious opportunistic infections are being reported in patients treated with ibrutinib. …”
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Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm by Gary M. Woods, Rajinder P. S. Bajwa, Samir B. Kahwash, Terri Guinipero

“…Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. …”
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Thiazolidinedione-Induced Fluid Retention: Recent Insights into the Molecular Mechanisms by Jerzy Bełtowski, Jolanta Rachańczyk, Mirosław Włodarczyk

“…These effects are mediated by PPARγ-induced nongenomic transactivation of the epidermal growth factor receptor and downstream extracellular signal-regulated kinases (ERK).…”
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Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition by Jonathan W. Nyce

“…The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues. …”
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Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower. by Mingzhu Zhao, Bing Yi, Xiaohong Liu, Dexing Wang, Dianxiu Song, Enyu Sun, Liangji Cui, Jingang Liu, Liangshan Feng

“…Most of DEGs were enriched in cell wall organisation, protein kinase activity, hormone, transcription factor activities, redox homeostasis, immune response, and secondary metabolism. …”
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Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia by Akile Ozlem Yurt

“…Lipopolysaccharide caused increase in damage indicator levels of heart, liver, kidney besides cholesterol and triglyceride (p<0.05) while meloxicam administration was inhibited increase in creatine kinase-MB and cholesterol levels but caused more increase in urea and triglyceride levels.…”
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Identification of a Novel Primary Atopic Disorder due to STAT6 Gain-of-Function Mutations by Safa Barış, Talal A. Chatila

“…A subset of IEI, which manifests as severe allergic disorders, recently termed "primary atopic disorders'', now encompasses over 30 monogenic defects. Notably, the Janus kinase (JAK)-signal transducer and activator of transcription 6 (STAT6) signaling pathway plays a pivotal role in mediating allergic responses and developing primary atopic disorders. …”
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Challenges in Treating Statin-Associated Necrotizing Myopathy by Patrick Webster, Nicholas Wiemer, Abdalhamid Al Harash, Cody Marshall, Nazia Khatoon, Michael Lucke

“…The primary presenting symptom of this condition is progressive symmetric proximal weakness that does not abate or worsens even after cessation of statin therapy and is associated with markedly elevated creatine kinase (CK) levels. To date, no randomized controlled trials have been conducted to identify the most effective treatment for statin-associated autoimmune myopathy. …”
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sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway by Yatao Bao, Meng Lian, Yong Chen, Xiaotian Gu, Kunyu Cao, Xiaoping Du, Jiyu Ju

“…The results showed that sNASP gene mutations can promote the response of the TLR4–TAK1 signaling pathway but have no significant effect on the TLR4–TBK1 signaling pathway. sNASP mutations enhanced TLR4-mediated nuclear factor-κ-gene binding and mitogen-activated protein kinase activation and IL-6, tumor necrosis factor secretion in murine peritoneal macrophages. …”
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Cellular Response upon Stress: p57 Contribution to the Final Outcome by Marianna Nicoletta Rossi, Fabrizio Antonangeli

“…Progression through the cell cycle is one of the most important decisions during the life of a cell and several kinds of stress are able to influence this choice. p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation. p57 loss has been reported in a variety of cancers and great effort has been spent during the past years studying the mechanisms of p57 regulation and the effects of p57 reexpression on tumor growth. …”
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Phospho-relay feedback loops control egress vs. intracellular development in Toxoplasma gondii by Ja E. Claywell, Yong Fu, L. David Sibley

“…A positive feedback loop involving protein kinase G (PKG) and calcium-dependent PKs (CDPKs) controls motility, invasion, and egress by Toxoplasma gondii, while PKA isoform c1 (PKAc1) counteracts this pathway. …”
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Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years by Yoji Shido, Yukihiro Matsuyama

“…Pazopanib is a multitargeted tyrosine kinase inhibitor that has been clinically available from November 2012 in Japan. …”
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