Rational Design for Improving the Thermostability of Saccharomyces cerevisiae Nicotinamide Riboside Kinase 1 by WANG Yao, SHEN Taisong, LI Sichen, SHI Hongling, YAO Lunguang, TANG Cunduo

Subjects: “…nicotinamide riboside kinase 1; rational design; site-directed mutagenesis; thermal stability; nicotinamide mononucleotide…”
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Delirium and High Creatine Kinase and Myoglobin Levels Related to Synthetic Cannabinoid Withdrawal by Ahmet Bulent Yazici, Esra Yazici, Atila Erol

“…Previous studies on alcohol delirium cases suggested that elevated creatine kinase (CK) can be a marker of progress. This study reports delirium and high serum CK levels related to SC withdrawal and offers a treatment with benzodiazepine for them. …”
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Janus kinase inhibitors and biologics for treatment of livedoid vasculopathy: a systematic review by Yu Liu, Tingting Li, Wei Shi

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Afatinib and Necitumumab in EGFR-Mutant NSCLC with Acquired Resistance to Tyrosine Kinase Inhibitors by Nathaniel J. Myall, MD, Jennifer G. Whisenant, PhD, Joel W. Neal, MD, PhD, Wade T. Iams, MD, Karen L. Reckamp, MD, Sally York, MD, PhD, Lynne D. Berry, PhD, Yu Shyr, PhD, Leora Horn, MD, Heather A. Wakelee, MD, Sukhmani K. Padda, MD

“…Introduction: Although tyrosine kinase inhibitors (TKIs) are effective against NSCLC harboring sensitizing EGFR gene mutations, acquired resistance is inevitable. …”
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Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits by Ji‐Sun Moon, Hyun Kyung Kim, Sun Young Shin

“…To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits. …”
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Stress-Activated Protein Kinases (SAPKs) in IGF-I Mediated Cell Survival by Darren Krause, Anthony Lyons, Patrick Walsh, Rosemary O’Connor

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Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases by Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García

Subjects: “…protein kinases…”
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Unraveling the protein kinase C/NDRG1 signaling network in breast cancer by C. Saponaro, M. Damato, E. Stanca, S. Aboulouard, F. A. Zito, S. De Summa, D. Traversa, L. Schirosi, S. Bravaccini, F. Pirini, E. Fonzi, M. Tebaldi, M. Puccetti, A. Gaballo, L. Pantalone, M. Ronci, L. Magnani, D. Sergi, A. Tinelli, S. Tacconi, L. Siculella, A. M. Giudetti, I. Fournier, M. Salzet, M. Trerotola, D. Vergara

“…Analysis of the TCGA dataset showed a significant positive correlation between NDRG1 and PRKCA expression, suggesting a mechanistic role of protein kinase C (PKC) in the regulation of NDRG1. We then assessed the hypothesis that PKC might modulate the activity of NDRG1, and observed that different acute stress conditions converging on PKC activation lead to enhanced NDRG1 expression. …”
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Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases by Magdalena Klink, Henryk Tchorzewski, Zofia Sulowska

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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

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Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China by Junhua Wu, Ming Qin, Yue Gao, Yang Liu, Xiaona Liu, Yuting Jiang, Yanmei Yang, Yanhui Gao

Subjects: “…creatine kinase…”
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Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes. by Ranjit K Deka, Shih-Chia Tso, Wei Z Liu, Chad A Brautigam

“…This protein also exhibited acetate kinase activity, and it was amenable to structural and biophysical studies. …”
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Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses by Yumei Shi, Zhifang Zhang, Zhenghao Yan, Honglong Chu, Changxin Luo

Subjects: “…mitogen-activated protein kinases…”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

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Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer? by Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

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Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Mouse Model of Autism by Shiyu Tang PhD, Elizabeth M. Powell PhD, Wenjun Zhu MS, Fu-Sun Lo MD, Reha S. Erzurumlu PhD, Su Xu PhD

“…MET , the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD). …”
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Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors by George Nicolae Daniel Ion, George Mihai Nitulescu, Dragos Paul Mihai

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Unveiling the Anti-Angiogenic Potential of Small-Molecule (Kinase) Inhibitors for Application in Rheumatoid Arthritis by Fatemeh Khodadust, Eva M. L. Philippon, Maarten M. Steinz, Jan Piet van Hamburg, Johan van Meerloo, Judy R. van Beijnum, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken

“…This study evaluated potential anti-angiogenic effects of several compounds including small-molecule kinase inhibitors, such as sunitinib (pan-kinase inhibitor), tofacitinib (JAK-inhibitor), NIKi (NF-κB-inducing kinase inhibitor), and the integrin-targeting peptide fluciclatide, using a scratch assay and 3D spheroid-based models of angiogenesis. …”
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Tirosin Kinase Inhibitors in Chronic Graft versus Host Disease: From Bench to Bedside by Jacopo Olivieri, Sabrina Coluzzi, Imma Attolico, Attilio Olivieri

“…In many inflammatory fibrotic diseases, such as Systemic Scleroderma (SSc) and cGVHD with fibrotic features, an abnormal activation of transforming growth factor (TGFβ) and platelet-derived growth factor receptor (PDGF-R) pathways have been observed. Tyrosin Kinase Inhibitors (TKIs), which are currently used for treatment of patients with Chronic Myeloid Leukemia (CML), share potent antifibrotic and antiinflammatory properties, being powerful dual inhibitors of both PDGF-R and TGFβ pathways. …”
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Stiff Substrates Enhance Endothelial Oxidative Stress in Response to Protein Kinase C Activation by Rebecca Lownes Urbano, Swathi Swaminathan, Alisa Morss Clyne

“…The objective of this study was to determine if substrate stiffness increased endothelial monolayer reactive oxygen species (ROS) in response to protein kinase C (PKC) activation and if this oxidative stress then impacted adherens junction integrity. …”
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