Genomic insights on cgMLST markers, drug resistance, and urease cluster of Proteus mirabilis strains by Shitao Lian, Yadong Liu, Songnian Hu, Chen Shen, Yinping Ma, Peng Yin, Zilong He

“…Furthermore, the prevalence of the urease gene cluster of P. mirabilis at the urease gene level may be associated with the formation of kidney stones. The objective of the study is to analyze the bacterium’s drug resistance, urease gene clusters, and gene distribution in genomes in order to facilitate the development of antimicrobial drugs and improve the treatment and control of P. mirabilis infections.…”
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The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer by Giuseppe Di Lorenzo, Carlo Buonerba, Raffaele Baio, Eleonora Monteleone, Francesco Passaro, Antonio Tufano, Vittorino Montanaro, Vittorio Riccio, Ilaria Gallo, Francesca Cappuccio, Federica Fortino, Anna Buonocore, Federica Monaco, Antonio Verde, Anna Rita Amato, Oriana Strianese, Ferdinando Costabile, Luca Scafuri

“…Higher fatigue scores were associated with lower well-being, female gender, and the presence of certain chronic conditions (cancer, kidney stones, gastric ulcers). Two distinct fatigue dimensions, “physical fatigue and functional impacts” and “emotional and social consequences”, were identified. …”
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Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet by Lingyue An, Shujue Li, Zhenglin Chang, Min Lei, Zhican He, Peng Xu, Shike Zhang, Zheng Jiang, Muhammad Sarfaraz Iqbal, Xinyuan Sun, Hongxing Liu, Xiaolu Duan, Wenqi Wu

“…Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal disease. …”
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Which Measure of Stone Burden is the Best Predictor of Interventional Outcomes in Urolithiasis: A Systematic Review and Meta-analysis by the YAU Urolithiasis Working Group and EAU... by Robert Geraghty, Amelia Pietropaolo, Lazaros Tzelves, Riccardo Lombardo, Helene Jung, Andreas Neisius, Ales Petrik, Bhaskar K. Somani, Niall F. Davis, Giovanni Gambaro, Romain Boissier, Andreas Skolarikos, Thomas Tailly

“…We considered all studies reporting prognostic accuracy statistics on any intervention for kidney stones (extracorporeal shockwave lithotripsy [ESWL], ureterorenoscopy [URS], or percutaneous nephrolithotomy [PCNL]; Population) using multiplane measurements of stone burden (area in mm2 or volume in mm3; Intervention) in comparison to single-plane measurements of stone burden (size in mm; Intervention) for the study-defined stone-free rate (Outcome) in a PICO-framed question. …”
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Development of a novel predictive model for a successful stone removal after flexible ureteroscopic lithotripsy based on ipsilateral renal function: a single-centre, retrospective... by Hong Li, Liang Zhou, Xi Jin, Yucheng Ma, Zhongyu Jian, Liyuan Xiang, Deyi Luo, Kun-Jie Wang

“…The Hodges-Lehmann test and calibration curve analysis revealed no significant mismatch between the prediction model and the retrospective cohort.Conclusion Ipsilateral renal function may be a novel independent risk factor for kidney stone removal with flexible ureteroscopic lithotripsy. …”
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Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement by Ibrahim Khalil, MBBS, Ahmed Fahim Faiyaz, MBBS, Md. Imran Hossain, MBBS, Mahmuda Akter, MBBS

“…Imaging revealed bilateral renal enlargement with hemorrhagic cysts, a kidney stone, and hepatic cysts causing hepatomegaly. …”
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Novel Approach for Endoscopic Management of Duodenal Injury during Perirenal Infected Haematoma Drainage after Shock-Wave Lithotripsy by Nariman Gadzhiev, Dmitry Gorelov, Alexander Smirnov, Salman Al-Shukri, Sergei Petrov

“…A 57-year-old patient with the 15 mm right pelvic kidney stone underwent uneventful SWL. Patient visited emergency department 3 days later with high fever and chills with severe right flank pain. …”
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Screening of Indigenous Oxalate Degrading Lactic Acid Bacteria from Human Faeces and South Indian Fermented Foods: Assessment of Probiotic Potential by Sivasamy Gomathi, Ponnusamy Sasikumar, Kolandaswamy Anbazhagan, Sundaresan Sasikumar, Murugan Kavitha, M. S. Selvi, Govindan Sadasivam Selvam

“…Lactic acid bacteria (LAB) have the potential to degrade intestinal oxalate and this is increasingly being studied as a promising probiotic solution to manage kidney stone disease. In this study, oxalate degrading LAB were isolated from human faeces and south Indian fermented foods, subsequently assessed for potential probiotic property in vitro and in vivo. …”
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Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization by Xue L, Tao Q, Chang H, Yan S, Wang L, Zhao Z, Tu C

“…Urate transporter 1 (URAT1) inhibitors are known to enhance uric acid elimination via the kidneys, but they also increase the risk of kidney stone formation. Currently, xanthine oxidase (XO) inhibitors are the predominant uric-lowering medications on the market.Methods: In this study, we utilized single-cell RNA sequencing, spatial metabolomics, plasma metabolomics, flow cytometry to explore the effects of Tigulixostat on uric acid level and hyperuricemic nephropathy (HN) in Uox-KO mouse model.Results: In this study, we discovered that Tigulixostat (LC350189) more effectively reduced SUA levels and resulted in better renal outcomes compared to allopurinol, without inducing liver injury in urate oxidase knockout (Uox-KO) mice. …”
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The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study by Tristan Pascart, Elie Dauphin, Chio Yokose, Charlotte Jauffret, Aurore Pacaud, Victor Laurent, Vincent Ducoulombier, Hyon K. Choi, Jean-François Budzik

“…One case of calyceal calculi and one case of ureterolithiasis were observed, wrongly coded as MSU in default post-processing settings for gout but identified as uric acid in the “kidney stone” settings. Five patients had MSU-coded plaques in the renal arteries, which had DECT parameters consistent with early calcified plaques rather than MSU, and had no association with volumes of peripheral MSU deposition.Conclusion DECT is unable to detect genuine monosodium urate crystal deposits in kidneys and renal artery walls, and but can characterize chronic asymptomatic urolithiasis.…”
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