DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner by Jianling Song, Yanxia Chen, Yan Chen, Minzi Qiu, Wenliu Xiang, Ben Ke, Xiangdong Fang

“…Background Chronic kidney disease (CKD) lacks effective treatments and renal fibrosis (RF) is one of CKD’s outcomes. …”
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Spot Urine Estimations Are Equivalent to 24-Hour Urine Assessments of Urine Protein Excretion for Predicting Clinical Outcomes by Boon Wee Teo, Ping Tyug Loh, Weng Kin Wong, Peh Joo Ho, Kwok Pui Choi, Qi Chun Toh, Hui Xu, Sharon Saw, Titus Lau, Sunil Sethi, Evan J. C. Lee

“…The use of spot urine protein to creatinine ratios in estimating 24 hr urine protein excretion rates for diagnosing and managing chronic kidney disease (CKD) predated the standardization of creatinine assays. …”
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Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis by Shingo Hatakeyama, Hiromi Murasawa, Itsuto Hamano, Ayumu Kusaka, Takuma Narita, Masaaki Oikawa, Daisuke Noro, Kazuhisa Hagiwara, Hirofumi Ishimura, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Tomihisa Funyu, Chikara Ohyama

“…Estimates of prognosis and prognostic factors may provide useful information for physicians as well as elderly patients with end-stage kidney disease.…”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…In addition, a 5/6 nephrectomy (5/6 Nx) rat model and cecal ligation and puncture (CLP) were used to verify the effect of chronic kidney disease (CKD) and sepsis on CD73-adenosine signaling.Results: Decreased CD73+ T cells were independently associated with increased infection risk over one and three years. …”
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Human cytomegalovirus (HCMV) trends in Sri Lanka: insights from a hospital-based seroprevalence analysis by Narapity Pathirannehalage Sunil-Chandra, Madawala Vithanage Madusha Lakmali Jayasundara, Maththe Gama Ralalage Shobha Sanjeewani Gunathilaka, Suduwa Dewage Himal Suminda

“…Methods A total of 820 blood samples obtained from 820 participants of selected low and high-risk populations in Sri Lanka, namely; hospital inpatients (n = 200), antenatal women (n = 80), blood donors (n = 80), cancer patients (n = 200), Sexually Transmitted Disease (STD) clinic attendees (n = 160) and Chronic Kidney Disease (CKD) patients on haemodialysis (n = 100) were tested for IgG antibodies against HCMV by Enzyme Linked Immunosorbent Assay (ELISA). …”
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Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

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Pituitary Adenylate Cyclase-Activating Polypeptide Protects Glomerular Podocytes from Inflammatory Injuries by Kenichi Sakamoto, Kyoko Kuno, Minoru Takemoto, Peng He, Takahiro Ishikawa, Shunichiro Onishi, Ryoichi Ishibashi, Emiko Okabe, Mayumi Shoji, Akiko Hattori, Masaya Yamaga, Kazuki Kobayashi, Harukiyo Kawamura, Hirotake Tokuyama, Yoshiro Maezawa, Koutaro Yokote

“…Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease; however, there are few treatment options. …”
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Cardiovascular Profile and Cardiovascular Imaging After Bariatric Surgery: A Narrative Review by Mihaela Toader, Liliana Gheorghe, Costin Chirica, Ionuț-Alexandru Ghicu, Sabina-Ioana Chirica, Andreea Isabela Mazga, Danisia Haba, Mădălina Maxim, Ancuța Andreea Miler, Daniela Crișu, Mihai Ștefan Cristian Haba, Daniel Vasile Timofte

“…Additionally, obesity contributes to an increased probability of developing certain types of cancer, osteoarthritis, urinary incontinence, and chronic kidney disease. In this review, we focused especially on the cardiovascular status of obese patients who underwent bariatric procedures. …”
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Blood pressure control with active ultrafiltration measures and without antihypertensives is essential for survival in hemodiafiltration and hemodialysis programs for patients with... by Franklin Geovany Mora-Bravo, Pamela Tatiana Morales Torres, Nelson Rojas Campoverde, Guillermina Lucía Blum Carcelen, Juan Cristobal Santacruz Mancheno, Ángel Cristóbal Santacruz Tipanta, Hector Perez-Grovas, Willan Patricio Robles Abarca

“…Abstract Background High blood pressure is a prevalent condition in patients with chronic kidney disease on hemodialysis. Adequate control of high blood pressure is essential to reducing deaths in this group. …”
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Risedronate Attenuates Podocyte Injury in Phosphate Transporter-Overexpressing Rats by Yohei Asada, Takeshi Takayanagi, Tsukasa Kawakami, Eisuke Tomatsu, Atsushi Masuda, Yasumasa Yoshino, Sahoko Sekiguchi-Ueda, Megumi Shibata, Tomihiko Ide, Hajime Niimi, Eishin Yaoita, Yusuke Seino, Yoshihisa Sugimura, Atsushi Suzuki

“…Osteoporosis patients with chronic kidney disease (CKD) are becoming common in our superaging society. …”
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Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis by Yijuan Sun, Amarpreet Sandhu, Darlene Gabaldon, Jonathan Danaraj, Karen S. Servilla, Antonios H. Tzamaloukas

“…For the first eight years, he had stable stage III chronic kidney disease attributed to bladder outlet obstruction secondary to prostatic malignancy. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Confounders included for adjustment were age, sex, and comorbidities (hypertension, hyperlipidemia, coronary artery disease, obesity, diabetic retinopathy, chronic kidney disease, and insulin treatment). Furthermore, propensity score (PS) matching method was used to choose the matched sample, and PS-adjusted Cox regression was performed. …”
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Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients by Dan Chen, Wenwu Sun, Jia Li, Bohua Wei, Wei Liu, Xiaopin Wang, Fan Song, Liangkai Chen, Junhui Yang, Li Yu

“…In the adjusted logistic regression analyses, the highest cystatin C level and ln-transformed cystatin C levels were independently associated with the risks of developing critically ill COVID-19 and all-cause death either in overall patients or in patients without chronic kidney disease (P values < 0.05). As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients. …”
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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…Background/Aims. Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease. …”
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Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction: a systematic review and meta-analysis by Kyle White, Ian Scott, Mansey Kinarivala

“…Compared with T1MI, patients with T2MI were: more likely to have pre-existing chronic kidney disease (OR 1.87; 95% CI 1.53 to 2.28) and chronic heart failure (OR 2.35; 95% CI 1.82 to 3.03), less likely to present with typical cardiac symptoms of chest pain (OR 0.19; 95% CI 0.13 to 0.26) and more likely to present with dyspnoea (OR 2.64; 95% CI 1.86 to 3.74); more likely to demonstrate non-specific ST-T wave changes on ECG (OR 2.62; 95% CI 1.81 to 3.79) and less likely to show ST elevation (OR 0.22; 95% CI 0.17 to 0.28); less likely to undergo coronary angiography (OR 0.09; 95% CI 0.06 to 0.12) and percutaneous coronary intervention (OR 0.06; 95% CI 0.04 to 0.10) or receive cardioprotective medications, such as statins (OR 0.25; 95% CI 0.16 to 0.38) and beta-blockers (OR 0.45; 95% CI 0.33 to 0.63). …”
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Knowledge, attitude and practice regarding screening and managing diabetic microvascular complications among general practitioners of community health centres: a cross-sectional st... by Hua Yang, Jian Gao, Ying Yu, Cuiling Huang, Chengdian Lan, Zhangyan Chen

“…Objective To evaluate the knowledge, attitude and practice (KAP) regarding screening and managing diabetic microvascular complications, encompassing diabetic retinopathy (DR), diabetic kidney disease (DKD) and diabetic neuropathy (DN), among general practitioners (GPs).Design Cross-sectional study.Setting The online questionnaire survey was conducted between April and July 2023.Participants GPs from community health centres (CHCs) in all 16 districts of Shanghai were recruited.Primary and secondary outcome measures The data of sociodemographic characteristics, KAP scales, training experience and screening instruments for community screening and managing diabetic microvascular complications were collected. …”
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Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes by Weihui Yu, Hong Zhu, Xiong Chen, Xuejiang Gu, Xingxing Zhang, Feixia Shen, Weiping Jia, Cheng Hu

“…Evidences suggested that FGF21 may play a protective role against diabetic kidney disease (DKD). However, the relationship between genetic variants in the FGF21 gene region and DKD remains unknown. …”
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Associations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults by Yu-Wei Fang, Wei-Chung Huang, Chikang Wang, Chien-Yu Lin

“…This association was particularly pronounced in participants without chronic kidney disease (CKD), with a <i>p</i>-value for the interaction between DNAmCystatinC and CKD on all-cause mortality of 0.002. …”
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Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation by Rasmus K. Carlsen, Anders Åsberg, Anders Åsberg, My Svensson, My Svensson, Kåre I. Birkeland, Kåre I. Birkeland, Hanne S. Jørgensen, Hanne S. Jørgensen, Iain Bressendorff, Hanne L. Gulseth, Hanne L. Gulseth, Karsten Midtvedt, Espen Nordheim, Espen Nordheim, Trond G. Jenssen

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Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements by Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Silvia Urciuoli, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Nicola Di Daniele, Annalisa Romani

“…Moreover, gender differences have been reported in nephrology, as it has been observed that chronic kidney disease has higher prevalence in males than in females. …”
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