Prognostic signature of multimorbidity, geriatric syndromes and resources cluster in older in- and outpatients: a pooled secondary analysis with a 6-month follow-up by Thomas Benzing, Jill Stegemann, Anna Maria Affeldt, Luisa Mück, Anne Ferring, Laura Gerhards, Lena Pickert, Annika Bausch, Philipp Antczak, M Cristina Polidori

“…Additionally, two clusters were identified pertaining to the CIRS, encompassing sensory-vegetative and heart-kidney morbidity. Patients within the iatrogenic cluster exhibited significantly higher MPI and readmissions during follow-up compared with those outside this cluster (p<0.001). …”
Get full text

Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity by Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang

“…To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line. Among the altered sgRNAs, a significant enrichment of those targeting the E2F transcription factor 1 (E2F1) gene was observed in surviving HK-2 cells in the AAI-treated group. …”
Get full text

Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice by Tatsuhito Himeno, Hideki Kamiya, Keiko Naruse, Zhao Cheng, Sachiko Ito, Taiga Shibata, Masaki Kondo, Jiro Kato, Tetsuji Okawa, Atsushi Fujiya, Hirohiko Suzuki, Tetsutaro Kito, Yoji Hamada, Yutaka Oiso, Kenichi Isobe, Jiro Nakamura

Get full text

Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice by Tomohiro Komatsu, Toshihiro Sakurai, Anna Wolska, Marcelo J. Amar, Akiko Sakurai, Boris L. Vaisman, Denis Sviridov, Stephen Demosky, Milton Pryor, Katsunori Ikewaki, Alan T. Remaley

“…In case of apoC-II mutant mice, decreased uptake of radioactive lipids was observed in the liver and kidney after addition of C-II-a to the lipid emulsion. …”
Get full text

Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…In mouse models, ramR L58P and F165L mutants showed lower bacterial burden in organs (spleen, lung, and kidney) 6 h post‐infection, and are fast cleared in 48 h. …”
Get full text

Laying the groundwork: Exploring pesticide exposure and genetic factors in south-eastern Brazilian farmers by Débora Dummer Meira, Victor Nogueira Da Gama Kohls, Matheus Correia Casotti, Luana Santos Louro, Gabriel Mendonça Santana, Thomas Erik Santos Louro, Adriana Madeira Alvares da Silva, Lorena Souza Castro Altoé, Raquel Reis Trabach, Sonia Groisman, Elizeu Fagundes de Carvalho, Jamila Alessandra Perini Machado, Stephanie Seneff, Iúri Drumond Louro

“…Our results indicate that normal metabolizers may be more susceptible to conditions such as high blood pressure, cardiovascular disease, and kidney problems. Intermediate metabolizers show an association with attention deficit disorder and miscarriages, suggesting that farmers’ symptoms correlated with their CYP2C9 genotype. …”
Get full text

Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial by Alberto Esteban-Fernández, Alberto Esteban-Fernández, Alejandro Recio-Mayoral, Raquel López-Vilella, Raquel López-Vilella, Gregorio de Lara, Moisés Barrantes-Castillo, Inés Gómez-Otero, Inés Gómez-Otero, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Carolina Robles-Gamboa, José López-Aguilera, Ángel Iniesta-Manjavacas, Paula Fluviá, Francisco Pastor-Pérez, Laia Belarte-Tornero, Gonzalo Alonso-Salinas, Pablo Díez-Villanueva

“…Patients in VERISEC were older and had more comorbidities (diabetes, advanced chronic kidney disease) compared to VICTORIA, with 20% having an estimated glomerular filtration rate below 30 ml/min. …”
Get full text

Hubungan Jenis Organ dan Jumlah Organ yang Mengalami Gangguan dengan Prognosis dan Outcome pada Pasien Malaria Falciparum Berat di RSUP Dr. M. Djamil Padang by Riche Anggresti, Nuzulia Irawati, Roza Kurniati Kurniati

“…Inferential that there are relation/ having a meaning of between existence of organ disfunction with prognosis (p = 0.03), severe malaria falciparum patient with disfunction brain, liver, kidney and spleen, with one organ type or more will experience of ugly prognosis. …”
Get full text

Determining the incidence, risk factors and biological drivers of irritable bowel syndrome (IBS) as part of the constellation of postacute sequelae of SARS-CoV-2 infection (PASC) o... by Erika Austhof, Kelly M Heslin, Xiaoxiao Sun, Kristen Pogreba Brown, Caitlyn M McFadden, Caroline Scranton, Ivan Vujkovic-Cviji, Dominic Rodriguez, Laura Falk, Gayatri Arani, Victoria Obergh, Kate Bessey, Kerry Cooper

“…This R01 study is being funded by the National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK135483-01) from 2023 to 2028.Methods and analyses This study combines a longitudinal epidemiologic cohort study and in-depth, novel biologic analyses. …”
Get full text

Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB by Yongzhan Sun, Quan Zou, Huizheng Yu, Xiaoping Yi, Xudan Dou, Yu Yang, Zhiheng Liu, Hong Yang, Junya Jia, Yupeng Chen, Shao-Kai Sun, Lirong Zhang

“…Autosomal dominant polycystic kidney disease (ADPKD) is a chronic genetic disorder closely associated with increased oxidative stress and featured by the progressive enlargement of cysts originating from various segments of the renal tubules. …”
Get full text

Clinical, pathological, and genotypic analysis of infectious bronchitis virus in broiler chickens in the Abu Dhabi Emirate, United Arab Emirates by Hassan Zackaria Ali Ishag, Abdelnasir Mohammed Adam Terab, Ebrahim Mohamad Abdalsalam Osman, El Tigani Ahmed El Tigani-Asil, El Tigani Ahmed El Tigani-Asil, Mohammed Saleh Albreiki, Oum Keltoum Bensalah, Asma Abdi Mohamed Shah, Abdelmalik Ibrahim Khalafalla

“…The cases were investigated through clinical and pathological examinations and Forty-six samples, including lung, spleen, kidney tissues, and oro-cloacal swabs, were collected for further analysis. …”
Get full text

Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…The treatment of the first episode implies two aspects: induction of remission and sustainment of remission. The recent Kidney Disease Improving Global Outcomes, American Academy of Pediatrics and German guidelines for the initial treatment of the first episode of a nephrotic syndrome recommend a 12-week course of prednisone. …”
Get full text

Changes in cancer incidence and stage during the COVID-19 pandemic in 2020–2021 in the Nordic countries by Anna Johansson, Anna Skog, Tom Børge Johannesen, Tor Åge Myklebust, Simon M. Kønig, Charlotte Wessel Skovlund, Lina Steinrud Mørch, Søren Friis, Marnar Fríðheim Kristiansen, David Pettersson, Eva María Gudmundsdóttir, Nanna Margrét Kristinsdóttir, Helgi Birgisson, Sandra Irenaeus, Johan Ahlgren, Mats Lambe, Elli Hirvonen, Janne Pitkäniemi, Giske Ursin

“…During 2020, colon cancer rates declined in Denmark and Iceland, while rectal cancer rates declined in Denmark, and lung and kidney cancer rates declined in Norway. Interpretation: During 2020–2021, cancer incidence rates declined across the Nordic countries with the largest declines in Sweden. …”
Get full text

Effect of Hyperthermic Intraperitoneal Perfusion Chemotherapy Combined with Radical Surgery and Capecitabine on Stage III Gallbladder Cancer by Sulai Liu, Zhendong Zhong, Weimin Yi, Zhangtao Yu, Zhihua Zhang, Guoyi Xia, Bo Jiang, Yinghui Song, Chuang Peng

“…There was no liver and kidney damage in the two groups after surgery. The platelets in the HIPEC group were less than those in the control group (P<0.05). …”
Get full text

Adaptation of the nutrition care process for metabolic diseases in the Mexican population by Magdalena Sevilla-González, Magdalena Sevilla-González, Magdalena Sevilla-González, Ailema González-Ortiz, Ailema González-Ortiz, María Victoria Landa-Anell, Marco A. Melgarejo-Hernández, Marco A. Melgarejo-Hernández, Ana Teresa Arias-Marroquín, Fabiola Mabel Del Razo-Olvera, Fabiola Mabel Del Razo-Olvera, Berenice Monserrat Román-Calleja, Ana Victoria Monreal-Lugo, Angélica J. Martin-Vences, Karime Haua-Navarro, Angeles Espinosa-Cuevas

“…A team of registered dietitians from two tier 3 hospitals, each with over five years of experience in metabolic disease management, customized the NCP’s four core steps—assessment, diagnosis, intervention, and monitoring—to meet the specific needs of the Mexican population.ResultsWe adapted the NCP to manage five common metabolic disorders: obesity, type 2 diabetes, kidney disease, metabolic dysfunction-associated steatotic liver disease, and dyslipidemia. …”
Get full text

Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout by Bin Yang, Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun, Erwei Sun

“…In vivo, the bioreactor prolonged circulation time, significantly reduced uric acid levels, alleviated kidney damage, and mitigated symptoms of hyperuricemia and gout. …”
Get full text

Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…Blood biochemistry analysis showed abnormalities in liver function and kidney function indicators in crab-eating monkeys with spontaneous spondyloarthritis. …”
Get full text

Vaccarin suppresses diabetic nephropathy through <?A3B2 pi6?>inhibiting the EGFR/ERK1/2 signaling pathway by Zhu Xuexue, Meng Xinyu, Du Xinyao, Zhao Chenyang, Ma Xinyu, Wen Yuanyuan, Zhang Shijie, Hou Bao, Cai Weiwei, Du Bin, Han Zhijun, Xu Fei, Qiu Liying, Sun Haijian

“…>Diabetic nephropathy (DN) is recognized as one of the primary causes of chronic kidney disease and end-stage renal disease. Vaccarin (VAC) confers favorable effects on cardiovascular and metabolic diseases, including type 2 diabetes mellitus (T2DM). …”
Get full text

Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor by Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan

“…Introduction: Nuclear receptor corepressor 1(NCOR1) is reported to play crucial roles in cardiovascular diseases, but its function in the kidney has remained obscure. Objective: We aim to elucidate the role of collecting duct NCOR1 in blood pressure (BP) regulation. …”
Get full text

Etelcalcetide: What we know eight years since its approval by Pedro Freitas, Luciano Pereira

“…Introduction and objectives: The impact of etelcalcetide on patients with chronic kidney disease (CKD) and secondary hyperparathyroidism (SHPT) has been studied since its introduction in 2016/2017. …”
Get full text