Dyslipidemia and metabolic syndrome in childhood-onset systemic lupus erythematosus: is it time to screen? by Sirin Nuntasri, Sirirat Charuvanij, Kraisoon Lomjansook, Puthita Saengpanit, Kwanjai Chotipanang, Maynart Sukharomana

“…Patients aged 10–19 years with cSLE diagnosed before 18 years and at least 1 year follow-up were enrolled, excluding those with other autoimmune disorders, chronic kidney disease, infections, receiving lipid lowering drugs prior, and pregnancy. …”
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Safety of vancomycin-loaded cement spacers for treating gram-positive periprosthetic joint infections in two-stage resection arthroplasty among patients with renal insufficiency by Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Yung-Chieh Liang, Pang-Hsin Hsieh, Sheng-Hsun Lee, Sheng-Hsuan Lin

“…This study hypothesizes that there is no significant correlation between antibiotic levels in blood and synovial fluid and the patient’s kidney function, and that the success rates of staged resection arthroplasty are comparable between groups, specifically targeting gram-positive bacterial infections. …”
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Differences in dialysis modality choice between immigrant and native populations in Barcelona, Spain by María Dolores Arenas-Jiménez, Jose Luis Fernandez-Martin, Isabel Galcerán Herrera, Marisol Fernández-Chamarro, Guillermo Pedreira-Robles, Silvia Collado Nieto, Julia Farrera Núñez, Eva Rodríguez García, Alicia Moreno Rodríguez, Laura Morro Fernández, Marta Crespo Barrio, Julio Pascual Santos

“…Keywords: advanced chronic kidney disease, socioeconomic status, demographic factors, shared decision making, renal replacement therapy, peritoneal dialysis, conservative care, hemodialysis, renal transplantation, language barrier, social determinants of health, immigration, social determinants of health. …”
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Anti-influenza effects of Aloe vera gel on MDCK cells: protective efficacy against ultraviolet-C exposure and analysis of biochemical characteristics and microbial activities by Rasha A. Al-Eisa, Rokayya Sami, Ruqaiah I. Bedaiwi, Roqayah H. Kadi, Suzan A. Abushal, Doaa Mahmoud Johari, Afnan M. Alnajeebi, Reham M. Algheshairy, Abeer A. Abu-Zaid, Sami A. Al-Dhumri

“…The main objective of the current study was to examine the anti-influenza effects of Aloe vera gel on the Madin–Darby Canine Kidney (MDCK) cell line, as well as its protective efficacy against ultraviolet-C exposure, by studying its biochemical characterization and microbial activities. …”
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Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus by Kanana Rungprasert, Wikanda Tunterek, Phornphisut Areeraksakul, Duangduean Prakairungnamthip, Chalida Sri-in, Navapon Techakriengkrai, Wijit Banlunara, Christine A. Jansen, Teerawut Nedumpun, Aunyaratana Thontiravong

“…Our results demonstrated that all conditions of BPL treatment (1:2000, 1:3000, and 1:4000 (vol/vol) concentration; 24, 48, and 72 h of incubation) could completely inactivate cluster 2.1 DTMUV, as evidenced by the absence of cytopathic effect (CPE) and DTMUV antigens after 3 passages in baby hamster kidney (BHK-21) cells. However, BPL at 1:4000 (vol/vol) concentration with 24 h of incubation preserved both the total protein content and the antigenic integrity of cluster 2.1 DTMUV more effectively than other conditions. …”
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The relevance of a multidomain geriatric assessment in older patients with heart failure by Emma E.F. Kleipool, Julia H.I. Wiersinga, Marijke C. Trappenburg, Albert C. vanRossum, Carmen S. vanDam, Su‐San Liem, Mike J.L. Peters, M. Louis Handoko, Majon Muller

“…Logistic regression analyses adjusted for age, sex, diabetes and kidney function assessed 3 month risk of adverse health outcomes (emergency department visits, hospital admissions, and/or death) according to HF severity, physical frailty, and number of affected domains. …”
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Hepatitis B Virus-Related Glomerulonephritis: Not a Predominant Cause of Proteinuria in Korean Patients with Chronic Hepatitis B by Jeong-Ju Yoo, Jeong-Hoon Lee, Jung-Hwan Yoon, Minjong Lee, Dong Hyeon Lee, Yuri Cho, Eun Sun Jang, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Hyo-Suk Lee

“…However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical outcomes of HBV-GN. …”
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Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…Ethnopharmacological relevanceEucommia ulmoides, recognized as a traditional Chinese medicinal herb, can tonify liver and kidney and strengthen bones and muscles. Modern pharmacological research has proved that E. ulmoides could prohibit the occurrence of osteoporosis and arthritis.AimTo investigate the effect and action mechanism of total flavonoids isolated from the leaves of E. ulmoides (TFEL) on bone loss in ovariectomized (OVX) rats, and to study its effect on intestinal flora.Materials and methodsThe 3-month-old female rats were randomly divided into six groups: sham operation group, OVX model group, estradiol group, TFEL low (TFEL-L) (50), mid (-M) (100) and high (-H) (200 mg/kg/d) dose groups. …”
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P<0.001), shock (P=0.002), acute kidney injury (AKI) (P<0.001), acute liver injury (ALI) (P=0.002), and gastrointestinal (GI) dysfunction (P=0.012), but not respiratory failure, brain injury, and pathogenic species (all P>0.05). …”
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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…In this model, once-daily injections of CV1574-1 for 5 days partially restored the pegvisomant-induced decrease in growth plate height without increasing kidney cell proliferation. Furthermore, we found that subcutaneous CV1574-1 showed significantly reduced hypoglycemic effect compared to injection of IGF-1 itself. …”
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Anaesthesia provision, infrastructure and resources in the Heilongjiang Province, China: a cross-sectional observational study by Jian Zhang, Hui Wang, Fei Han, Ge Jiang, Xi Zhang, Guonian Wang, Xiaoyu Zheng, Jingshun Zhao, Dandan Yao, Wanchao Yang, Xuesong Ma, Xiaodi Lu, Xidong Zhu, Meijun Chen, Mingyue Zhang

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Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>) by Youbin Yu, Liang Wang, Wenyun Huang, Duo Yu, Qiaoxuan Sun, Mingcao Cui

“…Results of immune response analyses showed that there was a clear decrease in immunoglobulin M (IgM), complement component 4 (C4), and lysozyme (LZM) in serum, lysozyme (LZM) genes, tumor necrosis factor-alpha (TNF-α) genes and interleukin-1β (IL-1β) genes in the head kidney of large yellow croakers reared in the HD group. …”
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Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum by Inês Carvalho, Inês Carvalho, Diogo Peixoto, Diogo Peixoto, Inês Ferreira, Inês Ferreira, Diego Robledo, Diego Robledo, Lourenço Ramos-Pinto, Rodolfo Miguel Silva, José Fernando Gonçalves, Marina Machado, Carolina Tafalla, Benjamin Costas, Benjamin Costas

“…These findings, together with the lower mRNA expression of proinflammatory genes in the head kidney and the higher mortality rates observed in this group, suggest a potential impairment of the immune response.…”
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On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations by Alexander Pushkin, Liyo Kao, Hristina R. Zhekova, Rustam Azimov, Natalia Abuladze, Xuesi M. Shao, D. Peter Tieleman, Ira Kurtz, Ira Kurtz

“…Here we report TOR measurements of the electrogenic Na+-CO32− cotransporter NBCe1-A (SLC4A4) and the kidney specific AE1 splice variant, kAE1, that play important roles in renal bicarbonate absorption and are mutated in proximal and distal renal tubular acidosis respectively. …”
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Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure by Dan Liu, Li Liu, Nan Li, Yiling Zhou, Hongmei Huang, Jidong He, Heling Yao, Xiangyang Chen, Xiaochi Tang, Miye Wang, Ying Qi, Si Wang, Ye Zhu, Haoming Tian, Zhenmei An, Sheyu Li

“…The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. A multivariable Cox proportional regression model was utilized to evaluate the association between the AST/ALT ratio and outcomes. …”
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Penggunaan Obat Antihipertensi pada Pasien Hipertensi Esensial di Poliklinik Ginjal Hipertensi RSUP DR. M. Djamil Tahun 2011 by Heri Fitrianto, Syaiful Azmi, Husnil Kadri

“…Compositions of 103 hypertension patients with complience indications are 63 patients with diabetes mellitus, 13 patients with PJK, 13 patients with stroke, 7 patients with heart failure, 4 patients with post-infarct myocardium, and 3 patients with chronic kidney failure. Concerning the usage of anti-hypertension medicines which were frequently i.e. …”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

“…Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer whose incidence and mortality rate are increasing. …”
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Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis by Kris Aubrey-Bassler, John-Michael Gamble, Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo A Marra, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen

“…Random effects models were used to estimate pooled relative risks (RRs).Intervention SGLT2 inhibitors, compared with placebo or active comparators.Primary outcomes Acute kidney injury (AKI), diabetic ketoacidosis (DKA), urinary tract infections (UTI), bone fractures and lower limb amputations.Results We screened 2418 citations of which 109 were included. …”
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Case report: Single infusion of combined anti-CD20 and anti-CD38 monoclonal antibodies in pediatric refractory lupus nephritis by Decimo Silvio Chiarenza, Raul Mancini, Carolina Bigatti, Carolina Bigatti, Gianluca Caridi, Alessandro Consolaro, Alessandro Consolaro, Valentina Natoli, Valentina Natoli, Gabriele Mortari, Xhuliana Kajana, Francesca Lugani, Marco Gattorno, Marco Gattorno, Gian Marco Ghiggeri, Edoardo La Porta, Gabriele Gaggero, Enrico E. Verrina, Andrea Angeletti

“…Lupus nephritis (LN), present in 30%–50% of systemic lupus erythematosus (SLE) patients, often necessitates standard immunosuppressive therapy (glucocorticoids, MMF, CYC) as suggested by the European League Against Rheumatism/European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) and Kidney Disease Improving Global Outcomes (KDIGO) guidelines. …”
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Association between the triglyceride-glucose index and contrast-induced nephropathy in chronic total occlusion patients undergoing percutaneous coronary intervention by Serdar Söner, Adem Aktan, Raif Kılıç, Hamdullah Güzel, Ercan Taştan, Metin Okşul, Adnan Duha Cömert, Mehmet Sait Coşkun, Hülya Tosun Söner, Tuncay Güzel

“…In multivariable logistic regression analysis, it was seen that age (OR = 1.04, 95% CI = 1.01–1.08, P = 0.020), chronic kidney disease (OR = 2.34, 95% CI = 1.02–5.33, P = 0.044), peripheral artery disease (OR = 5.66, 95% CI = 1.24–25.91, p = 0.026), LVEF (OR = 0.95, 95% CI = 0.92–0.99, P = 0.005), LDL cholesterol levels (OR = 1.00, 95%CI = 1.00–1.02, P = 0.024) and TyG index (OR = 2.17, 95% CI = 1.21–3.89, P = 0.009) were independent predictors of the development of CIN. …”
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