Escherichia coli in the T11-12 Thoracic Vertebrae: A Case Report by Weng D, Zhou H, Huang G, Cao Q, Wang H, Cao Z, Xie Q

“…Dandan Weng,1,* Hongyuan Zhou,1,* Guancheng Huang,1 Qingren Cao,2 Huafeng Wang,3 Zhujun Cao,2 Qing Xie2 1Department of Infectious Diseases, Yuyao People’s Hospital, Ningbo, Zhejiang, People’s Republic of China; 2Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing Xie; Zhujun Cao, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, People’s Republic of China, Email xieqingrjh@163.com; estherlucifer@163.comBackground: Pyogenic thoracic spondylitis is a rare but severe infection, particularly when complicated by sepsis and acute kidney injury (AKI). Early diagnosis and precise management are essential for improving outcomes, given the limitations of traditional microbiology detection methods in identifying the causative pathogens.Case Presentation: A 68-year-old immunocompetent male presented with recurrent fever, fatigue, loss of appetite and initial evidence of sepsis and AKI upon admission. …”
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High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury by Sayantap Datta, Mohammad Atiqur Rahman, Saisudha Koka, Krishna M. Boini

“…High mobility group box 1(HMGB1) is a highly conserved non-histone chromatin associated protein that largely contributes to the pathogenesis of chronic inflammatory and autoimmune diseases such as sepsis, atherosclerosis, and chronic kidney diseases. Hence, the present study tested whether HMGB1 contributes to nicotine-induced podocyte injury.Methods and ResultsBiochemical analysis showed that nicotine treatment significantly increased the HMGB1 expression and release compared to vehicle treated podocytes. …”
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Trends in Clinico-radiological and Laboratory Characteristics of All-Cause Meningoencephalitis in Western Rajasthan by Ravi Krishna Kanth, Samhita Panda, Sarbesh Tiwari, Taruna Yadav, Gopal Krishana Bohra, Ravi Shekar Gadepalli

“…Fever, altered sensorium, speech disturbances, neck stiffness, albumin, total leukocyte count, erythrocyte sedimentation rate, C-reactive protein, kidney and liver function tests showed significant association with mortality. …”
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The serum levels of gasdermin D in uremic patients and its relationship with the prognosis: a prospective observational cohort study by XiaPing Zhang, Bo Yang

“…Objective This study aimed to explore the serum levels of gasdermin D (GSDMD) in uremic (end-stage kidney disease, ESKD) patients and their correlation with vascular calcification (VC) and clinical results.Methods This prospective observational cohort study enrolled 213 ESKD patients who were undergoing regular maintenance hemodialysis (MHD) for > 3 months in our hospital from August 2019 to July 2022. …”
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Factors Associated with Visit-to-Visit Variability of Blood Pressure Measured as Part of Routine Clinical Care among Patients Attending Cardiology Outpatient Department of a Tertia... by Thirunavukarasu Kumanan, Vathulan Sujanitha, Mahesan Guruparan, Nadarajah Rajeshkannan

“…When comparing mean SD among the categories of different variables, female sex (P=0.023) and comorbidities such as diabetes mellitus (DM) (P=0.013), chronic kidney disease (CKD) (P=0.007), and risk of developing obstructive sleep apnoea (OSA) (P=0.04) showed significant variation. …”
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Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model by Yannick Carlos Tcheutchoua, Danielle Claude Bilanda, Yolande Sandrine Mengue Ngadena, Paul Désiré Djomeni Dzeufiet, Pascal Emmanuel Owona, Ronald Bidingha á Goufani, Rodrigue Ngapout Fifen, Lohik Mbolang Nguegan, Michel Noubom, Théophile Dimo, Pierre Kamtchouing

“…The study showed that the aqueous extract of the mixture of B. pilosa and C. citratus has a low toxicity and does not cause any injury to the liver, kidney, lungs, or spleen.…”
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A mouse model of immunosuppression facilitates oral Candida albicans biofilms, bacterial dysbiosis and dissemination of infection by Raja Veerapandian, Anuja Paudyal, Sarah M. Schneider, Sonny T. M. Lee, Govindsamy Vediyappan, Govindsamy Vediyappan

“…Although no visible damage was observed in the kidney and liver, except increased lipid vacuoles in the liver cells, C. albicans was found in the liver homogenate. …”
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Risk-Stratified Cardiovascular Screening Including Angiographic and Procedural Outcomes of Percutaneous Coronary Interventions in Renal Transplant Candidates by Julian König, Martin Möckel, Eda Mueller, Wolfgang Bocksch, Seema Baid-Agrawal, Nina Babel, Ralf Schindler, Petra Reinke, Peter Nickel

“…Benefits of cardiac screening in kidney transplant candidates (KTC) will be dependent on the availability of effective interventions. …”
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Cost-effectiveness of Chloride-liberal versus Chloriderestrictive Intravenous Fluids among Patients Hospitalized in the United States by Louise Perrault, Dilip Makhija, Idal Beer, Suzanne Laplante, Sergio Iannazzo, Karthik Raghunathan

“…**Background:** Patients developing acute kidney injury (AKI) during critical illness or major surgery are at risk for renal sequelae such as costly and invasive acute renal replacement therapy (RRT) and chronic dialysis (CD). …”
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Occult Hepatitis B Infection among Hemodialysis Patients in Tabriz, Northwest of Iran: Prevalence and Mutations within the S Region by Narges Eslami, Vahdat Poortahmasebi, Javid Sadeghi, Reza Ghotaslou, Bahram Niknafs, Hossein Bannazadeh Baghi, Mahin Ahangar Oskouee

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Development and validation of highly sensitive multiplex real-time RT-PCR assay for detection of classical swine fever virus genome by A. S. Sadchikova, A. S. Igolkin, R. S. Chernyshev, A. A. Kozlov, I. S. Kolbin, A. V. Sprygin, D. A. Biryuchenkov, I. A. Chvala, A. Mazloum

“…For comparative analysis of the developed as say sensitivity, swabs, samples of organs and tissues collected from pigs experimentally infected with an epizootic strain of the classical swine fever virus (spleen, kidney, liver, blood, lymph nodes, rectal and oral smears), animal-contaminated feed and virus-containing material with known virus titres were also tested in parallel with coded test systems No. x1 andx2. …”
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Case Report: Prenatal diagnosis of novel compound heterozygous variants in WDR35 gene causing short-rib thoracic dysplasia 7 with or without polydactyly by Jianlong Zhuang, Junyu Wang, Zhengping Huang, Yu’e Chen, Chunnuan Chen

“…In addition, two compound heterozygous variants NM_015102.5:c.[1196A>G(p.E399G)];[1972C>T(p.R658*)] in NPHP4 gene were also identified in the fetus, which may be partially responsible for fetal kidney hyperechogenicity and oligohydramnios.ConclusionThis is the first study reporting a novel deletion compound combined with a causative missense variant in WDR35 leading to SRTD7. …”
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Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

“…Gene Ontology analysis revealed both general cancer processes, such as wound healing and epithelial cell proliferation, as well as cancer-specific processes, such as “angiogenesis” in the kidney and “ossification” in the lung. ExomiR targets were enriched for cancer-specific tumor suppressor genes and downregulated in PMN formed in lungs compared to normal. …”
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LncRNA GAS5 reduces blood glucose levels and alleviates renal fibrosis in diabetic nephropathy by regulating the miR-542-3p/ERBB4 axis by Qinghua Yin, Na Guo, Ruoxi Liao

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Study of the Radio-Protective Effects of Henna Mixed With Vinegar on the Skin of Irradiated Rats by Mojgan Hasanzade, Mohammad Taghi Bahreyni Toossi, Masoumeh Gharib, Shirin Taraz Jamshidi, Hamid Gholamhosseinian, Shokouhozaman Soleymanifard

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Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India by Mohit Chowdhry, R. N. Makroo, Mandhata Singh, Manoj Kumar, Yogita Thakur, Vandana Sharma

“…Preformed MICA antibodies independently increase the risk of kidney rejection and therefore recommend that guidelines should be formed for mandatory testing of these antibodies prior to renal transplant.…”
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Improved Outcome of Severe Acute Pancreatitis in the Intensive Care Unit by Polychronis Pavlidis, Siobhan Crichton, Joanna Lemmich Smith, David Morrison, Simon Atkinson, Duncan Wyncoll, Marlies Ostermann

“…Forty patients (80%) tolerated enteral nutrition, and 46% received antibiotics for non-SAP reasons. Acute kidney injury was significantly more common among hospital nonsurvivors compared to survivors (100% versus 42%, ). …”
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Subchronic Toxicity Study of Alternanthera philoxeroides in Swiss Albino Mice Having Antioxidant and Anticoagulant Activities by Shahad Saif Khandker, Morshed Alam, Forhad Uddin, Ummay Mahfuza Shapla, Nafisa Lubna, Tanusree Amy Mazumder, Mahfuza Marzan, Milon Mondal, Md Ibrahim Khalil, Nurul Karim, Md Salman Shakil, Md Sakib Hossen

“…Following that, the in vivo toxicological effects of methanolic extracts of A. philoxeroides using different doses on the kidney, heart, lung, liver, stomach, brain, and blood of female Swiss Albino mice were investigated. …”
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Adherence patterns, risk factors and complications among patients with tuberculosis: a cross-sectional study at Nsawam Government Hospital by Abraham Norman Nortey, Amanda Adjoda, Amidu Alhassan, Godfred Yawson Scott

“…Participants earning less than 500 Ghana Cedis (Ghc) (adjusted OR (aOR)=8.85. 95% CI (1.59 to 49.24), p=0.013), patients with TB who indicated having complication (joint pain, spinal pain, heart disorders, liver or kidney problems) as a result of TB (aOR=2.81, 95% CI (1.58 to 4.99), p<0.001), respondents who mentioned living with people infected with TB (aOR=3.23. 95% CI (1.24 to 8.37), p=0.016) were the independent predictors of adherence to TB medication.Conclusion The study findings revealed that participants exhibited commendable adherence to TB medication. …”
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Outcomes of adults hospitalized with COVID-19 at the University Teaching Hospital of Butare in Rwanda and validation of the Universal Vital Assessment (UVA) mortality risk score. by Dona Fabiola Gashame, Kwame A Akuamoah Boateng, Jean Damascene Twagirumukiza, Jean de Dieu Mahoro, Christopher C Moore, Theogene Twagirumugabe

“…Factors independently associated with mortality included acute kidney injury (adjusted odds ratio [aOR] 7.99, 95% confidence interval [CI] 1.47-43.22, p = 0.016), severe COVID-19 (aOR 3.42, 95% CI 1.06-11.01, p = 0.039), and a UVA score >4 (aOR 7.15, 95% CI 1.56-32.79, p = 0.011). …”
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