Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation by Shoukai Yu, Lingmei Qian, Liling Xu, Jun Ma

“…Significant downregulation of SOX2 expression was observed in colorectal adenocarcinoma, esophageal carcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and testicular germ cell tumors, whereas its expression was upregulated in cervical squamous cell carcinoma, glioblastoma multiforme, lower grade glioma, lung adenocarcinoma, and lung squamous cell carcinoma.Survival analysis showed that low SOX2 expression correlated with better prognosis in bladder cancer, liver hepatocellular carcinoma, kidney renal clear cell carcinoma, and sarcoma, whereas high SOX2 expression was associated with poor prognosis in lung adenocarcinoma, and lung squamous cell carcinoma, glioblastoma multiforme, lower grade glioma. …”
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Renal Dysfunction, Metabolic Syndrome and Cardiovascular Disease Mortality by David Martins, Chizobam Ani, Deyu Pan, Omolola Ogunyemi, Keith Norris

“…Renal disease is commonly described as a complication of metabolic syndrome (MetS) but some recent studies suggest that Chronic Kidney disease (CKD) may actually antecede MetS. Few studies have explored the predictive utility of co-clustering CKD with MetS for cardiovascular disease (CVD) mortality. …”
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CULTURAL PROPERTIES OF BOVINE RESPIRATORY SYNCYTIAL VIRUS STRAIN AB1908 by V. V. Kirpichenko, S. V. Kononova, A. V. Kononov, O. P. Byadovskaya, B. L. Manin, A. V. Sprygin

“…The tests performed showed that a continuous bovine turbinate (BT) cell line, continuous bovine fetal trachea (FBT) cell line and continuous bovine calf kidney (RBT) cell line are sensitive for cultivation of this agent and can be used to prepare viral suspension, needed for further research. …”
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Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis by Ryo Togashi, Yoshikazu Nemoto, Kaito Waki, Michito Nagura, Shigeyuki Arai, Yoshifuru Tamura, Yasutoshi Oshima, Fukuo Kondo, Ryuji Ohashi, Shunya Uchida, Shigeru Shibata, Yoshihide Fujigaki

“…At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine. Kidney biopsy revealed thin basement membrane nephropathy (TBMN) and focal segmental glomerulosclerosis (FSGS), which explained his urinary abnormalities. …”
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Uji Kesesuaian Hasil Pemeriksaan Sedimen Urine Metode Shih-Yung pada Volume Urine 10 mL dan 5 mL by Putri Niawaty, Rikarni Rikarni, Dwi Yulia

“…Pediatric patients and kidney disease patients with oliguria difficult to get 10mL urine samples, so it needs to be studied to determine the accuracy of results with smaller sample volumes. …”
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Toxicity Evaluation of a Polyphenolic Extract from Flourensia cernua DC through Artemia Lethality Assay, Hemolytic Activity, and Acute Oral Test by Yulma Lizbeth Aguirre-García, Ainara Castillo-Manzanares, Lissethe Palomo-Ligas, Juan Alberto Ascacio-Valdés, Lizeth Guadalupe Campos-Múzquiz, Sandra Cecilia Esparza-González, Raúl Rodríguez-Herrera, Sendar Daniel Nery-Flores

“…In addition, histological analysis suggested potential kidney damage at the 2000 mg/kg dose. According to OECD guidelines, while the extract can be classified as category 5 (low acute toxicity) due to the absence of mortality at 2000 mg/kg, the observed signs of toxicity should be considered in the overall risk assessment. …”
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The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years by Ngoc Minh Pham, Daigo Yoshida, Makiko Morita, Guang Yin, Kengo Toyomura, Keizo Ohnaka, Ryoichi Takayanagi, Suminori Kono

“…Study subjects were derived from the baseline survey of a cohort study on lifestyle-related diseases, and included 11.662 men and women aged 49–76 years; excluded were those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease. Statistical adjustment was made for body mass index, alcohol use, hypertension, diabetes mellitus, and other factors. …”
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5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice by Jingyao Zhang, Jianbin Bi, Sushun Liu, Qing Pang, Ruiyao Zhang, Shun Wang, Chang Liu

“…The tissue histopathology analysis revealed that 5-HT markedly exacerbated histological damages in the peritoneum, lung, liver, kidney, intestinal tissue, and heart in sepsis. Moreover, significant lower levels of TNF-α, IL-6, bacterial loads, MPO, and ROS were discovered in the KO-CLP sepsis group in contrast to the WT-CLP sepsis group. …”
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Vitamin D Toxicity Managed with Peritoneal Dialysis by Krystel Feghali, Kostas Papamarkakis, Jackson Clark, Neha Malhotra, Lanu Stoddart, Ibitoro Osakwe

“…He presented with biochemical evidence of hypercalcemia, acute kidney injury, and pancreatitis. Workup for his hypercalcemia led to the diagnosis of vitamin D toxicity as shown by a level greater than 200 ng/dL (Ref: 20–50 ng/mL) was confirmed by liquid chromatography-mass spectroscopy. …”
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The validity of the renal Doppler resistivity index in renal allograft infections by Moataz Fatthy, Karim M. Soliman, Éva Csongrádi, Abd El Rahman Marzouk, Ahmed Fathy, Ahmed Fayed

“…There was a statistically significant difference in RRI in those with allograft infections, with the ROC curve for detection of infection utilizing RRI demonstrated an Area Under Curve 0.634 (p-value 0.015; cutoff value: 0.765; CI:0.527–0.742), with a specificity of 64.4% and a sensitivity of 68.8%.Conclusion Normal renal graft arterial resistivity index values, despite a renal allograft dysfunction, may be indicative of allograft infection, guiding clinicians’ decisions regarding kidney biopsy and facilitating further biopsy interpretations.…”
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The Clinical and Pathological Effects of Serum C3 Level and Mesangial C3 Intensity in Patients with IgA Nephropathy by Xiaoyue Hou, Yanan Liang, Weiwei Zhang, Rong Li

“…Patients with strong mesangial C3 deposition and elevated lipid levels had more severe tubule atrophy and/or interstitial fibrosis, as well as more severe pathological lesions, suggesting that activation of the complement system is involved in the pathogenesis of IgA nephropathy and increases the metabolic burden of the kidney.…”
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Renal failure due to rectal neoplastic polyp: McKittrick–Wheelock syndrome—a case report by Ivan Valentinov Dimitrov, Theophil Angelov Sedloev, Ivan Petrov Vasilev, Slavyana Slavcheva Usheva, Yavor Asenov Nikolov, Nikolay Metodiev Penkov, Plamen Ivanov Penchev, Maria-Elena Boyadzhieva, Georgi Chavdarov Jelev

“…Excessive secretion from adenomas is an unusual clinical manifestation that leads to severe electrolyte and fluid depletion, subsequently resulting in kidney injury. Successful treatment relies on quick and cooperative decision-making for timely intervention. …”
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Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine by Akhilesh Kumar Verma, Subhash Chandra, Rana Gopal Singh, Tej Bali Singh, Shalabh Srivastava, Ragini Srivastava

“…SPA, TOS, TAS, and OSI can be used as biomarkers for diagnosis of kidney damage.…”
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Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease by Symeon Savvopoulos, Haralampos Hatzikirou, Herbert F Jelinek

“…Clinically, diabetes and associated comorbidities are identified by biochemical and physical characteristics including glycemia, glycated hemoglobin (HbA1c), and tests for cardiovascular, eye and kidney disease. Objectives: Diabetes may have a common etiology based on inflammation and oxidative stress that may provide additional information about disease progression and treatment options. …”
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Not “Much Room” in the Heart: A Rare Case of a Massive Intracardiac Candida Mass by Ali Haider Jafry, Sardar Hassan Ijaz, Murtaza Mazhar, Areeba Shahnawaz, Ali Yousif

“…Laboratory workup showed elevated inflammatory markers and an acute kidney injury. Extended blood cultures showed growth of Candida glabrata (C. glabrata) and Candida dubliniensis (C. dubliniensis). …”
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A Peculiar Cause of Shock: Analysing Two Clinical Cases by João Oliveira, Alberto Costa-Silva, Luís Vale, Daniel Costa, Rui Almeida-Pinto, Carlos Martins-Silva, Tiago Antunes-Lopes, João Silva

“…CT demonstrated a staghorn calculus, hydronephrosis, and signs compatible with xanthogranulomatous pyelonephritis in the right kidney. Additionally, and incidentally, it revealed a 60 mm nodule on the right adrenal gland. …”
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The Renal and Liver Complications Development among Patients with Type 2 Diabetes Mellitus in Kirkuk City by Wasan Talib Abed, Walaa Esmael Jassim, Emad Mohamed Rasheed

“… Diabetes is a chronic metabolic malady that has raised levels of blood glucose, which in last, it will cause severe harms to the heart, blood vessels, eyes, kidneys, and nerves. In this article trials to investigate the development of the renal and liver disorders among patients with T2DM in a population of Kirkuk city. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. …”
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Using the fuzzy cognitive map in designing a decision support system in diabetes insipidus by fatemeh haghani, alireza shahraki, Mohebali Rahdar

“…Because the initial symptoms of diabetes insipidus are very similar to diabetes mellitus and the differential diagnosis of different types of diabetes insipidus is important, this disease was investigated in the current research.Methodology: In this research, based on library studies and using the experiences and opinions of experts, the factors of central and renal diabetes insipidus were examined and determined; then, using Spss, FCMapper, and Pajek software, fuzzy cognitive maps were analyzed in order to investigate factors and relationships between them.Findings: The results of the analysis of fuzzy cognitive maps in central diabetes insipidus, the factors that improve urine concentration after taking vasopressin and urine volume > 40 ml/kg and osmolarity of 300 mosom/l, and in renal diabetes insipidus, the factors of kidney failure Synthetic vasopressin use (no change in urine concentration) and hyperuria were identified as the most influential and important variables that should be given special attention.Originality/Value: So far, no definitive treatment has been discovered for this disease, and if a person is infected with it, it will affect him for the rest of his life. …”
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Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older by Kun Zhao, Shan-Shan Yang, Hai-Bin Wang, Kang Chen, Zhao-Hui Lu, Yi-Ming Mu

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