Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…In vivo experiments revealed that SIRT2, VEGFA, and HIF-1α were highly expressed in the kidneys of mice with diabetic nephropathy. In conclusion, our study combines metabolomics and proteomics to provide valuable insights into the synergistic roles of metabolic disorders and inflammatory responses in DN. …”
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Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Lavandula angustifolia Essential Oils in Rabbit and Mice by Awol Mekonnen, Solomon Tesfaye, Selam G. Christos, Kassahun Dires, Tizazu Zenebe, Nigus Zegeye, Yoseph Shiferaw, Ermias Lulekal

“…No macroscopic changes were seen in the histopathology analysis of kidneys and livers. For skin irritation test shaved rabbit skin was treated with 10% ointment formulation. …”
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Chronic Benign CD8+ Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse by Marcela Osovská, Andrea Janíková, Leoš Křen, Andrea Marečková

“…Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. …”
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Study of african swine fevervirus reproduction in porcine primary bone marrow cell culture before and after cryopreservation by I. Yu. Zhukov, I. V. Shevchenko, N. N. Vlasova, A. A. Varentsova, B. L. Manin, O. S. Puzankova, V. L. Gavrilova, A. S. Igolkin

“…This paper presents data on the preparation of cells from porcine bone marrow, spleen, lymph nodes, kidneys and testicles used for African swine fever virus reproduction. …”
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Infantile Extracranial Rhabdoid Tumor of the Scalp by Sura Al Rawabdeh, Deifallah Alsharari, Hayat Khasawneh, Ola M. Al Waqfi, Qamar Yaser Malabeh, Hiathem Abu Alhaija, Raed Mohammad Aljubour, Hamzeh M. Alkhawaldeh

“…Extracranial rhabdoid tumor is a rare tumor that can originate in multiple organs, and it is most commonly seen in the kidneys. This tumor has a grave prognosis. We report to the best of our knowledge the first case of infantile scalp extracranial rhabdoid tumor in a 6-month-old male baby who presented with a right parietal scalp mass since the age of 1 month. …”
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Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions by Sibani Sarkar, Subhajit Karmakar, Malini Basu, Pratyasha Ghosh, Mrinal K Ghosh

“…At the early stage, the virus infects the lung epithelial cells and is slowly transmitted to the other organs including the gastrointestinal tract, blood vessels, kidneys, heart, and brain. The neurological effect of the virus is mainly due to hypoxia‐driven reactive oxygen species (ROS) and generated cytokine storm. …”
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Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats by Xin Xiao, Ochuko L. Erukainure, Md. Shahidul Islam

“…RHT also significantly (P < 0.05) decreased MDA levels and enhanced level of GSH, activity of SOD, catalase, GR in most of organs (pancreas, liver, kidneys, and heart). Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. …”
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PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control by So-Young Lee, Jun Mo Kang, Dong-Jin Kim, Seon Hwa Park, Hye Yun Jeong, Yu Ho Lee, Yang Gyun Kim, Dong Ho Yang, Sang Ho Lee

“…AICAR and metformin treatment effectively mitigated albuminuria and renal histopathology and decreased the expression of TGFβ1 and αSMA in the kidneys of diabetic mice. Conclusions. Our results demonstrate that increases in PGC1α activity improve diabetic tubulopathy by modulating mitochondrial dynamics and autophagy.…”
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Intrauterine growth‐restricted pregnant rats, from placental ischemic dams, display preeclamptic‐like symptoms: A new rat model of preeclampsia by Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith, Kylie Jones, Angie Castillo, Jordan Shaw, Joseph Editone III, Ahfiya Howard, Robert Tatum, Alex Smith, Brandon Fisher, George W. Booz, Mark Cunningham

“…Hallmarks of PE are placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys and brain. This study aims to characterize a new model of PE using pregnant IUGR rats from hypertensive placental ischemic dams. …”
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Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats by Maria Rosana Ramirez, Debora Manuale, Juan Carlos Yori

“…The weights of heart, liver, kidneys and spleen of the experimental rats with respect to body weight were recorded. …”
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SGLT-2 Inhibitors—a Culprit of Diabetic Ketoacidosis Postbariatric Surgery by Qasim Zafar Iqbal, Danil Mishiyev, Muhammad Raphay Niazi, Zeeshan Zia, Saud Bin Abdul Sattar, Abdullah Jahanghir, Shahed Quyyumi

“…They have grown increasingly popular over recent years, as they have been shown to have some protective effects on the heart and kidneys, both organ systems that diabetes mellitus has shown to have deleterious effect on over time. …”
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Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension by Ulla Kampmann, Ole N. Mathiassen, Kent L. Christensen, Niels H. Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L. Poulsen

“…Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. …”
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MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy by Yingying Zhang, Siqi Zhao, Depei Wu, Xingmei Liu, Mingjun Shi, Yuanyuan Wang, Fan Zhang, Jing Ding, Ying Xiao, Bing Guo

“…Moreover, microRNA-22 (miR-22) was upregulated and associated with reduced expression of its target gene phosphatase and tensin homolog (PTEN) in both the kidneys of DN rats and high glucose-cultured NRK-52E cells. …”
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Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice by Joy L. Kovar, Lael L. Cheung, Melanie A. Simpson, D. Michael Olive

“…YC-27 was cleared via the kidneys but bound the proximal tubules of the renal cortex and epididymis. …”
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IgG4-Related Disease without Overexpression of IgG4: Pathogenesis Implications by Naoshi Nishina, Yuko Kaneko, Masataka Kuwana, Hironari Hanaoka, Hideto Kameda, Shuji Mikami, Tsutomu Takeuchi

“…He was admitted due to a pituitary mass, systemic lymphadenopathy, and multiple nodules in the lungs and kidneys. The serum IgG4 level was normal and histopathological examination of the pituitary mass showed abundant lymphocyte and plasma cell infiltration with very few IgG4-positive cells. …”
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Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS by Meilin Yang, Die Liu, Yan Tan, Jieting Chen, Fan Yang, Chaoming Mei, Qi Zeng, Yong Lin, Dan Li

“…Molybdenum-based polyoxometalate (POM) is an excellent ROS-scavenging nanocluster, but its size is too small to be easily cleared by the kidneys, limiting its effectiveness in scavenging iRFA-induced ROS. …”
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Acute toxicity test combination of binahong leaves extract (Anredera cordifolia) and catfish oil (Pangasius micronema Blkr.) in mice by Rahma Shabrina Auliya, Meitasari Annisa Diyan, Sasongko Heru

“…The results showed that the symptoms of toxicity that appeared, body weight testing, and organs of the liver, heart, and kidneys of mice obtained a significance value of p>0.05 so there is no significant difference between the weight of mice’s hearts. …”
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Surveillance of pathogenic Leptospira among rodents and small mammals in enzootic areas of plague in Pasuruan Indonesia by Siti Amanah Febriani, Kurnia Ritma Dhanti, Kurniawan Kurniawan, Ristiyanto Ristiyanto, Arief Junaedi, Caecilia Hapsari Ceriapuri Sukowati, Farida Dwi Handayani

“…Simple random sampling was conducted to trap a total of 119 forms 107 rats and 12 small mammal kidneys were analyzed molecularly (PCR) to detect Leptospira bacteria with the LipL32 gene as the target. …”
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Genomic Variability among Field Isolates and Laboratory-Adapted Strains of Leptospira borgpetersenii Serovar Hardjo by Alejandro Llanes, Carlos Mario Restrepo, Pablo Riesgo-Ferreiro, Sreekumari Rajeev

“…Leptospira borgpetersenii serovar Hardjo colonizes cattle kidneys and may occasionally infect humans and other mammals. …”
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CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway by Qianguang Han, Bin Ni, Wei Bao, Junqi Zhang, Ming Zheng, Jinxu Miu, Zijie Wang, Jingwen Yuan, Jun Tao, Zhijian Han, Min Gu, Xiaobing Ju, Ruoyun Tan

“…BackgroundChronic allograft dysfunction (CAD) stands as a critical factor that limits the long-term viability of transplanted kidneys. Ferroptosis is an iron-dependent form of programmed cell death increasingly linked to chronic fibrosis. …”
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