The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation by Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang

“…In the present study, 25HC was applied to porcine deltacoronavirus (PDCoV)-infected LLC-PK1 (Lilly Laboratories Culture-Porcine Kidney 1) cells and piglets to explore its antiviral capacity and underlying mechanism. …”
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Cytomegalovirus Infection in Patient with Clear Cell Renal Cell Carcinoma by Ikhwan Rinaldi, Abdul Muthalib, Januar Widodo Sutandar, Hendro Adi Kuncoro, Bambang Irawan Harsono, Nelly Susanto, Tjondro Setiawan, Kevin Winston, Idham Rafly Dewantara, Ihya Fakhrurizal Amin, Yuli Maulidiya Shufiyani

“…While there have been several studies on CMV infection in post-transplant patients, there is limited literature on CMV infection in cancer, particularly in kidney cancer. Case Report. In this case report, we present the case of a 61-year-old man with clear cell renal cell carcinoma who underwent targeted therapy with the receptor tyrosine kinase (RTK) inhibitor lenvatinib and the mammalian target of rapamycin (mTOR) inhibitor everolimus. …”
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Transcription factor specificity protein (SP) family in renal physiology and diseases by Wei Zhou, Jiaxi Fang, Qingqing Jia, Hanyan Meng, Fei Liu, Jianhua Mao

“…A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules. …”
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Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa by H. M. Senarathna, C. L. Fonseka, H. A. S. Perera, P. U. T. De Silva, T. P. Weerarathna

“…We present a case of 54-year-old male with recently detected chronic kidney disease admitted with progressive severe disabling muscular pains predominantly over calves with constitutional symptoms for seven weeks. …”
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Serological and Molecular Diagnosis of Human Cytomegalovirus among Hemodialysis Patients in Kirkuk/Iraq by Eman Ammar Ihsan, Lezan Medhat Mohammed, Waleed Mohammed Ali

“…Patients exposed to CMV during dialysis may cause virus reactivation by immunosuppression and inflammation, suggesting that screening patients is necessary to avoid complications like kidney transplant rejection. As a result, PCR can detect extremely small amounts of DNA, it has a high detection rate in the early stages of CMV infection.…”
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A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. These effects might be elucidated by the upregulated inflammation-associated proteins in ΔarrS. …”
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WEIGHTED GENE CO-EXPRESSION NETWORK ANALYSIS IDENTIFIES BIOLOGICAL PATHWAYS AND BIOMARKER GENES ASSOCIATED WITH CHICKENS' ADAPTATION TO BOTH LOW AND HIGH ALTITUDES by Pshtiwan S.A. Bebane, Paiman Yousif, Sarbast I. Mustafa, Sami mamand

“… The main aim of the study was to identify modules, hub genes, and possible pathways linked with hypoxia adaptation in six types of tissues and organs (heart, kidney, liver, lung, muscle, and spleen) at altitudes ranging from 2,300 to 3,500 metersOn a transcription dataset from hypoxia-sensitive tissues, we performed weighted gene co-expression network analysis on 13,940 selected genes, and 10 transcriptional modules in total were detected (Turquoise 196 genes, Purple 27 genes, Blue 196, Brown 182, Yellow 108, Green 79 genes, Red 69 genes, Black 50 genes, Pink 44 genes, and Magenta 37 genes). …”
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Betalains protect various body organs through antioxidant and anti-inflammatory pathways by Nilesh Prakash Nirmal, Seema Medhe, Merina Dahal, Pankaj Koirala, Siriwan Nirmal, Fahad Al-Asmari, Baojun Xu

“…Body organs, including the heart, liver, kidney, lung, etc., are important for a healthy life. …”
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Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways by Abeer Bishr, Bassant M. El-Mokadem, Asmaa A. Gomaa

“…Abstract Despite the fact that canagliflozin (Cana), a sodium-glucose cotransporter 2 inhibitor, is an anti-diabetic medication with additional effects on the kidney, there is limited experimental data to deliberate its hepato-reno-protective potentiality. …”
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miRNA-Disease Association Prediction with Collaborative Matrix Factorization by Zhen Shen, You-Hua Zhang, Kyungsook Han, Asoke K. Nandi, Barry Honig, De-Shuang Huang

“…In addition, we used CMFMDA on Esophageal Neoplasms and Kidney Neoplasms to reveal their potential related miRNAs. …”
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Protective effect of exercise on animals with sepsis: a systematic review of the existing literature by Na Yang, Nan Jiang, Chunming Shen, Ming Gao, Qian Tong, Jian Sun

“…Our comprehensive descriptive analysis showed that exercise could improve the general condition, lung injury, liver injury, kidney injury, heart and aortic injury, spleen and thymus injury, and other injuries in animals with sepsis. …”
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Coexistent Pseudogout and Mycobacterium avium-intracellulare Septic Arthritis in a Patient with HIV and ESRD by Wais Afzal, Omer M. Wali, Kelly L. Cervellione, Bhupinder B. Singh, Farshad Bagheri

“…Although not very common, this entity can be seen in patients with chronic kidney disease (CKD). Septic arthritis due to Mycobacterium avium-intracellulare (MAI) is a rare entity that can affect immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS) or those who are on immunosuppressive drugs. …”
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Pauci-Immune Necrotizing and Crescentic Glomerulonephritis with Membranous Lupus Nephritis, Fifteen Years after Initial Diagnosis of Secondary Membranous Nephropathy by Ryan Burkhart, Nina Shah, Michael Abel, James D. Oliver, Matthew Lewin

“…We report a case of a 79-year-old Hispanic male with a history of secondary membranous nephropathy (diagnosed by renal biopsy 15 years previously) who was admitted with acute kidney injury and active urinary sediment. P-ANCA titers and anti-myeloperoxidase antibodies were positive. …”
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Antiviral activity of Ferula assa-feotida on HSV-1, 2 in vitro by Javad Charostad, Tahere Navidfar, Masoumeh Kiani, Paul Schinitzler, Akram Astani

“…The antiherpetic activity and Antiviral activity of Ferula were evaluated in Vero cells (African green monkey kidney cells) by using the plaque reduction assay. …”
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Association between balance ability and cardiovascular disease onsets among middle-aged and older adults: an observational cohort study from the China Health and Retirement Longitu... by Yinghe Lin, Shanshan Zhong, Zhihua Sun

“…Compared to those with good balance ability, individuals with moderate balance ability had a higher risk of incident CVD [HR (95% CI): 1.15 (1.03–1.28)], and the risk was more pronounced in female (20.0%), rural residence (21.0%), never smoking (22.0%), never drinking (23.0%), hypertension (16.0%), without dyslipidemia (17.0%), and without kidney disease (13.0%) participants. After multiple imputations of metabolic biomarkers data, the results of sensitivity analyses were generally consistent.ConclusionLower balance ability was associated with an increased risk of incident CVD among middle-aged and older Chinese adults. …”
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Gossypiboma secondary to ovariohysterectomy in a dog by Fabiano da Silva Flores, Carolina Cauduro da Rosa, Graciane Aiello, Anna Vitória Hörbe, Glaucia Denise Kommers, Luís Felipe Dutra Corrêa

“…During inspection of the abdominal cavity, a firm circular mass was observed adhered to the omentum and jejunum, caudal to the right kidney. Resection of the mass was performed, and then the mass sample was sent for histopathological examination, which revealed an encapsulated foreign body, consistent with surgical gauze. …”
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Incidence of Dysmagnesemia among Medically Hospitalized Patients and Associated Clinical Characteristics: A Prospective Cohort Study by Zahra Al Shukri, Juhaina Salim Al-Maqbali, Abdullah M. Al Alawi, Nafila Al Riyami, Sulaiman Al Riyami, Hiba Al Alawi, Qatiba Al Farai, Henrik Falhammar

“…Statistically significant associations were identified between hypermagnesemia and chronic kidney disease (CKD) (p = 0.05) and elevated creatinine levels (p < 0.01) and lower estimated glomerular filtration rate (eGFR) (p < 0.01). …”
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Bisphophonates in CKD Patients with Low Bone Mineral Density by Wen-Chih Liu, Jen-Fen Yen, Cheng-Lin Lang, Ming-Tso Yan, Kuo-Cheng Lu

“…Patients with chronic kidney disease-mineral and bone disorder (CKD-MBD) have a high risk of bone fracture because of low bone mineral density and poor bone quality. …”
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Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…These findings provide a foundation for understanding the pharmacodynamics and pharmacokinetics of TMAO and may aid in developing strategies for treating diseases, such as chronic kidney disease and neurological disorder where TMAO-serum albumins interaction are implicated.…”
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Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults,   a NHANES weighted analysis by Ling Liu

“…Weighted linear regression models adjusted for demographic, behavioral factors, and comorbidities (e.g., diabetes, kidney disease etc.), were employed to examine the independent association between cognitive health and OAB. …”
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