Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…As the S -enantiomer of ketamine, esketamine’s dosing guidelines and strict medical supervision stem from prior research on ketamine’s use in depression and history as a recreational drug. …”
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Resolution of depression: Antidepressant actions of resolvins by Satoshi Deyama, Katsuyuki Kaneda, Masabumi Minami

“…Although recent studies have demonstrated that ketamine, an N-methyl-D-aspartate receptor antagonist, produces rapid antidepressant effects in treatment-resistant patients, it also has undesirable side effects. …”
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Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases by Fikret Sahin, Aslihan Gunel, Buse Turegun Atasoy, Ulku Guler, Bekir Salih, Isinsu Kuzu, Mehmet Taspinar, Ozgur Cinar, Selda Kahveci

“…Abstract NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. …”
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Opioid sparing anesthesia in patients with liver cirrhosis undergoing liver resection: a controlled randomized double-blind study by Eman Sayed Ibrahim, Ahmed A. Metwally, Mohamed Abdullatif, Essam A. Eid, Mahmoud G. Mousa, Amany A. Sultan

“…Abstract Objective Opioid metabolism and pharmacodynamics may be affected in hepatic patients. Ketamine and dexmedetomidine are conventional anesthetics used in our daily practice. …”
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Immobilisation and Epidural Anaesthesia in a Eurasian Lynx (Lynx lynx) Undergoing Pelvic Limb Orthopaedic Surgery by Sonia Campos, Pierre Picavet, Olivier Bertrand, Charlotte Sandersen, Alexandru Tutunaru

“…The animal was remotely darted using a combination of ketamine (5 mg/kg) and xylazine (5 mg/kg) intramuscularly. …”
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Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions by Ryota Shinohara, Tomoyuki Furuyashiki

“…The mechanistic understanding of stress resilience might be exploitable for developing antidepressants based on a naturally occurring mechanism, thus safer than low-dose ketamine.…”
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NURSES AND PAIN MANAGEMENT IN TERRITORIAL HEALTH EMERGENCIES: A RETROSPECTIVE STUDY by Federico Pecetta, Gian Domenico Giusti, Sara Staffaroni, Matteo Ricci

“…Paracetamol was the most commonly used analgesic, followed by fentanyl, morphine, and ketamine. Conclusions: Pain assessment practices are well-established in pre-hospital care, but there is still room for improvement in pain management. …”
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Personal Construction of Cough Medicine among Young Substance Abusers in Hong Kong by Daniel T. L. Shek

“…Third, while the informants construed cough medicine to be similar to ketamine and marijuana, they also perceived cough medicine to possess some characteristics of heroin. …”
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Fibromyalgia: do I tackle you with pharmacological treatments? by Serge Perrot

“…Low-dose naltrexone and ketamine are gaining attention due their action on neuroinflammation and depression modulation, but treatment protocols have not been validated. …”
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Opioid Sparing Analgesics in Spine Surgery by Logan A. Reed, Mihir Patel, Kevin Luque, Steven M. Theiss

“…These opioid alternatives include acetaminophen, NSAIDs, COX-2 specific inhibitors, gabapentinoids, local anesthetics, dexamethasone, and ketamine. Each of these drugs presents its own advantages and disadvantages which can make it difficult to implement universally. …”
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Successful Removal of a Penile Constriction Ring in a 14-Year-Old Male by Timothy K. Suttle, Blake Palmer, Jonathan E. Heinlen, Christopher C. Roth, William G. Reiner, Dominic Frimberger

“…This case demonstrates the successful removal of a constricting metal ring from the penis of a 14-year-old male with a diamond blade equipped orthopedic oscillating saw while under ketamine anesthesia in the emergency department.…”
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Neonatal Nonketotic Hyperglycinemia: A Severe Case With Prenatal Indicators and Comprehensive Review of Recognition and Management by Samaneh Parviz, Dariush Hooshyar

“…Treatment included anticonvulsants for seizure management, sodium benzoate for glycine reduction, and NMDA receptor antagonists (ketamine and dextromethorphan) to modulate neurotoxicity. …”
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Vitreous Humour Extrusion after Suxamethonium Induction of Anaesthesia in a Polytraumatized Patient: A Case Report by Frederick Ebegue Amadasun, Theodore Ojeide Isesele

“…Anaesthesia was induced with 10 mg midazolam, 100 mg ketamine, and 100 mg suxamethonium given intravenously in sequence. …”
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The Current Consideration, Approach, and Management in Postcesarean Delivery Pain Control: A Narrative Review by L. Sangkum, T. Thamjamrassri, V. Arnuntasupakul, T. Chalacheewa

“…Risk factors for severe postoperative pain or analgesia-related adverse effects will require modifications to the standard analgesic regimen (e.g., the use of ketamine, gabapentinoids, or regional anesthetic techniques). …”
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Anaesthesia and the Acute Phase Protein Response in Children Undergoing Circumcision by Unase Buyukkocak, Fatma Caglayan, Osman Caglayan, Murat Basar, Murat Cakmak, Ertan Batislam, Sevgi Ulusoy

“…The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anaesthesia with mask, n=20), group 3 (ketamine, n=20), group 4 (local anaesthesia, n=35). …”
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Pengaruh Bone Marrow Mesenchymal Stem Cells Terhadap Sekresi VEGF pada Penyembuhan Luka Bakar Tikus by Gusti Revilla

“…Before that the treated rats anesthetized using xylazine and ketamine then burns are made on the dorsal with full thickness degrees. …”
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Tailoring anaesthetic strategies for diabetes research: Acepromazine vs. medetomidine in Aachen minipigs. by Sabrina Soares, Elisabeth Wühl, Alexander Schlund, Tobias Schneider, Kyra Sohns, Roman Rukwied, Martin Schmelz, Bettina Kränzlin

“…Acepromazine (ACE) was compared to medetomidine (MED) in association with butorphanol (BUT) and Ketamine (KET) and 4 parameters were analysed to define the optimum anaesthetic protocol including: sedation level, anaesthesia duration, effects on blood glucose and safety. …”
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From Serendipity to Precision: Integrating AI, Multi-Omics, and Human-Specific Models for Personalized Neuropsychiatric Care by Masaru Tanaka

“…<b>Background/Objectives</b>: The dual forces of structured inquiry and serendipitous discovery have long shaped neuropsychiatric research, with groundbreaking treatments such as lithium and ketamine resulting from unexpected discoveries. However, relying on chance is becoming increasingly insufficient to address the rising prevalence of mental health disorders like depression and schizophrenia, which necessitate precise, innovative approaches. …”
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A Case of Schizophrenia in a Young Male Adult with no History of Substance Abuse: Impact of Clinical Pharmacists’ Interventions on Patient Outcome by Mercy N. A. Opare-Addo, Josephine Mensah, Grace Owusu Aboagye

“…Medications administered to the patient while on admission included IV diazepam, IM haloperidol, IV Ketamine, IM flupentixol, olanzapine tablets, and trihexyphenidyl tablets. …”
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Research on treatment-related aspects of depression from India in the preceding decade (2014–2023): An updated systematic review by Alankrit Jaiswal, S Umesh, Nishant Goyal

“…Conclusion: More research is needed to understand the effectiveness and potential negative effects of depression treatments in India. Studies on ketamine have been inconclusive, and existing research on pharmacological agents is limited. …”
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