DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as scr... by Christopher D Byrne, Sam Wilding, Paul Remi Afolabi, Declan McDonnell, Victoria Goss, Jocelyn Walters, Zaed Z Hamady

“…This study will construct a predictive algorithm for PC, using two tests of pancreatic exocrine function, FE-1 test and the 13C-MTG breath test. Continuous flow isotope ratio mass spectrometry in the 13C-MTG breath test will be used to analyse enriched 13CO2 in exhaled breath samples. …”
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Teeth macroabrasion for determination of dental age and diet in the Illyrian population from the Kopila necropolis on the Island of Korčula, Croatia by Marina Marić, Dinko Radić, Jelena Dumančić, Marin Vodanović, Minja Birimiša, Davorka Radovčić, Hrvoje Brkić

“…The analysis of the stable isotope 14C determined the exact time of death of the analyzed individuals. …”
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Unusual open-system behaviour revealed by LA-MC-ICP-MS U–Th dating of coral and coralline algae bio-carbonates by Condomines, Michel, Bruguier, Olivier, Hajji, Inès, Zaara-Ben Mosbah, Chedia

“…The ages (from 196 to 182 ka) show that the coral-rich sediments were deposited near the end of isotope stage 7. The precision on the dates is comparable to those of alpha-spectrometry (around 7.6% on average), but the possibility of multiple in-situ analyses offers other advantages. …”
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Benchmarking Water-Limited Yield Potential and Yield Gaps of Shiraz in the Barossa and Eden Valleys by Marcos Bonada, Paul R. Petrie, Vinod Phogat, Cassandra Collins, Victor O. Sadras

“…Yield gaps increased with an increasing vine water deficit, as quantified by the carbon isotope composition of the fruit. The yield gap was smaller with higher rainfall before budburst, putatively favouring early-season vegetative growth and allocation to reproduction, and with higher rainfall between flowering and veraison, putatively favouring fruit set and berry growth. …”
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Improved Risk Prediction of Acute Myocardial Infarction in Patients With Stable Coronary Artery Disease Using an Amino Acid-Assisted Model by Yi-Jing Zhao, Yong Li, Feng-Xiang Wang, Hao Lv, Yaoyao Qu, Lian-Wen Qi, Pingxi Xiao

“…This methodology incorporated 13C isotope-labeled internal standards for precise quantification of 27 amino acids. …”
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On a data-driven mathematical model for prostate cancer bone metastasis by Zholaman Bektemessov, Laurence Cherfils, Cyrille Allery, Julien Berger, Elisa Serafini, Eleonora Dondossola, Stefano Casarin

“…While treatment with the radioactive isotope radium-223 ($ ^{223} $Ra) has shown promising results, there remains room for therapy optimization. …”
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament by Emmajay Sutherland, Christopher J. Harding, Tancrède du Monceau de Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster

“…Pre-steady-state kinetics, a significant solvent kinetic isotope effect, and the absence of viscosity effects suggested that a step linked to FMN regeneration controlled the reaction rate. …”
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Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease by Omkolsoum Mohamed Alhaddad, Ayman Alsebaey, Mohamed Omar Amer, Hala Hany El-Said, Tary Abdel Hamid Salman

“…One hundred HCV related end stage liver cirrhosis patients were randomized into two groups: Group I (n=35), patients with GFR < 60 mL/m measured by isotope scanning of the kidney (Renogram), and Group II (n=65), patients with GFR ≥ 60 mL/m. …”
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From plants to patterns: Constructing a comprehensive online strontium isoscape for Belgium (IsoBel) using high density grid mapping by Amanda Sengeløv, Giacomo Capuzzo, Sarah Dalle, Hannah F. James, Charlotte Sabaux, Elisavet Stamataki, Marta Hlad, Carina T. Gerritzen, Emma M. Legrand, Barbara Veselka, Guy De Mulder, Rica Annaert, Mathieu Boudin, Kevin Salesse, Eugène Warmenbol, Nadine Mattielli, Christophe Snoeck, Martine Vercauteren

“…Understanding the spatial distribution of strontium isotopes in plants or other archives within a region is crucial for various fields, including archaeology, environmental studies, food sciences and forensic science. …”
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Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts by Ewa Gutmajster, Joanna Witecka, Magdalena Wyskida, Justyna Koscinska-Marczewska, Malgorzata Szwed, Magdalena Owczarz, Malgorzata Mossakowska, Andrzej Milewicz, Monika Puzianowska-Kuznicka, Jan Zejda, Andrzej Wiecek, Jerzy Chudek, Aleksander L. Sieron

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Organic Matter Accumulation Mechanism in the Lower Cambrian Strata from Well Luntan 1 in the Tarim Basin, NW China by Qian Deng, Haizu Zhang, Haozhe Wang, Zhiwei Wei, Bin Cheng, Shida Li, Yunpeng Wang, Oluwabamise Lekan Faboya, Zewen Liao

“…Total organic carbon (TOC) content, carbon isotope of kerogen (δ13Cker), and major and trace elements of the rocks from the Sinian Qigebulake, Cambrian Yuertusi, and Xiaoerbulake Formations in well Luntan 1 were analysed. …”
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A Novel Liquid Chromatography–Tandem Mass Spectrometry Method to Quantify Tryptophan and Its Major Metabolites in Serum to Support Biomarker Studies in Patients with Cancer Undergo... by Anna Siemiątkowska, Barbara Kuźnar-Kamińska, Katarzyna Kosicka-Noworzyń, Kamila Nowaczewska, Hanna Winiarska, Dominika Popiołek, Filip Kamiński, Franciszek K. Główka

“…We also recorded a mutual cross-talk between kynurenine and isotope-labeled TRP. Different origins of the observed cross-signal contribution were proposed. …”
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A machine learning model using the snapshot ensemble approach for soil respiration prediction in an experimental Oak Forest by S.N. Ferdous, J.P. Ahire, R. Bergman, L. Xin, E. Blanc-Betes, Z. Zhang, J. Wang

“…Recent advances in ecosystem process models have uniquely constrained soil respiration rates, largely based on results from tracing ecosystem CO2 losses using radioisotope and stable isotope methods. However, the computational requirements of process-based models at large scales are costly, limiting their application and prediction capability. …”
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Policy relevance of IPCC reports for the Sustainable Development Goals and beyond by Prajal Pradhan, Sushobhan Joshi, Kshitij Dahal, Yaunchao Hu, Daya Raj Subedi, Muhammad Panji Islam Fajar Putra, Shrijana Vaidya, Laxmi Prasad Pant, Shobhakar Dhakal, Klaus Hubacek, Maheswar Rupakheti, Debra C. Roberts, Bart van den Hurk

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Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…MS detection was performed by a triple quadrupole tandem mass spectrometer in the multiple reaction monitoring mode with a positive electrospray ionization source. Isotope-labeled internal standard, especially rifampicin-D8, was applied to adjust for the loss during sample treatment. …”
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Petrology of the Eocene alkaline volcanism from the western Rio Grande Rise, South Atlantic Ocean by Julia Taciro Mandacaru Guerra, Valdecir de Assis Janasi, Priyeshu Srivastava, Priyeshu Srivastava, Miguel Angelo Stipp Basei, George Luiz Luvizotto, Luigi Jovane

“…Moreover, results from Pb, Sr and Nd isotope analysis reveal that Eocene alkaline volcanic rocks from the Western Rio Grande Rise have EMI-flavored Tristan-type signatures. …”
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Black Hole Supernovae, Their Equation of State Dependence, and Ejecta Composition by Oliver Eggenberger Andersen, Evan O’Connor, Haakon Andresen, André da Silva Schneider, Sean M. Couch

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Detection Methods for Asparagine and Glutamine Contents in Fruits and Vegetables and Recommendations for Dietary Intake of Fruits and Vegetables in Patients with Urea Cycle Disorde... by YE Xinyu, LI Ziying, TANG Shujun, SUN Liping, ZHAO Yunxia, XIAO Weimin, GU Yaping, KUANG Huiying, CHEN Xin, YANG Guowu, HUANG Yali

“…The mass spectrometer was equipped with an electrospray ionization source and operated in the positive ion mode with multiple reaction monitoring (MRM), and quantification was achieved using stable isotope-labeled internal standards. The calibration curves for Asn and Gln showed a good linearity in the range of 10–1 000 ng/mL (R2 > 0.999), with limit of detection (LOD) and limit of quantification (LOQ) of 1.5 and 5.0 mg/100 g, respectively. …”
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Comprehensive analysis of advanced glycation end-products in commonly consumed foods: presenting a database for dietary AGEs and associated exposure assessment by Qiaozhi Zhang, Huatao Li, Ruixing Zheng, Lili Cao, Shufen Zhang, Shuifeng Zhang, Huadong Sheng, Yuhao Jiang, Yanbo Wang, Linglin Fu

“…In this study, we first established an isotope dilution UHPLC-QqQ-MS/MS-based method for simultaneous quantification of 10 major AGEs in foods. …”
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Genesis of the Bieyesamas Monzogranite of the Altay Mountain, Xinjiang, Northwestern China, and Its Rare Metal Resource Potential by Gengbiao Qiao, Xiaoyan Chen, Wenming Li

“…According to LA-ICP-MS zircon U-Pb isotopic dating, the 206Pb/238U weighted average age of the Bieyesamas monzogranite is 451.1±5.1 Ma (MSWD=6.0), indicating the formation age of Late Ordovician. …”
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