Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. …”
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Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation by Annette Plesner, C. Bruce Verchere

“…The initial step in successful islet transplantation is procurement of healthy donor islets. …”
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Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

Subjects: “…islet organoids…”
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Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets by Myungji Kim, Seungyeon Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang

“…Abstract Pancreatic islets are densely packed cellular aggregates containing various hormonal cell types essential for blood glucose regulation. …”
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Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability by Bradley P. Weegman, Venkata Sunil Kumar Sajja, Thomas M. Suszynski, Michael D. Rizzari, William E. Scott III, Jennifer P. Kitzmann, Kate R. Mueller, Thomas R. Hanley, David J. Kennedy, Paul W. Todd, Appakalai N. Balamurugan, Bernhard J. Hering, Klearchos K. Papas

“…Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. …”
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In Vitro and In Vivo Improvement of Islet Quality and Transplantation Successes following Islet Treatment with Biomaterials in Diabetic Rats by Marzieh Nemati, Zahra Ebrahimi, Narges Karbalaei, Sanaz Dastghaib, Sara Khakshournia, Mojtaba Sargazi

“…Background. Loss of islet survival and function, caused by native niche disruption and oxidative stress induction during mechanical and enzymatic isolation, limits the effectiveness of islet transplantation. …”
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Oxygenation of the Intraportally Transplanted Pancreatic Islet by Thomas M. Suszynski, Efstathios S. Avgoustiniatos, Klearchos K. Papas

“…Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. …”
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Islet Cell Biology, Regeneration, and Transplantation by A. N. Balamurugan, Velayutham Kumaravel, Subbiah Pugazhenthi, Bashoo Naziruddin

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Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell by Feng-Fei Li, Bi-Jun Chen, Wei Li, Ling Li, Min Zha, S. Zhou, M. G. Bachem, Zi-Lin Sun

“…We previously isolated islet stellate cells (ISCs) from healthy Wistar rat islets. …”
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Protein-Mediated Interactions of Pancreatic Islet Cells by Paolo Meda

“…The islets of Langerhans collectively form the endocrine pancreas, the organ that is soley responsible for insulin secretion in mammals, and which plays a prominent role in the control of circulating glucose and metabolism. …”
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Homeostatic T Cell Proliferation after Islet Transplantation by Paolo Monti, Lorenzo Piemonti

“…Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. …”
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Advancements and Challenges in Immune Protection Strategies for Islet Transplantation by Xue Wang, Ziyuan Zeng, Dayan Li, Kai Wang, Wei Zhang, Yang Yu, Xi Wang

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Developing a New Method for Detecting Islet Apoptosis by I. H. Al-Abdullah, O. Cabrera, L. Inverardi, A. Pileggi, A. Pugliese, C. Ricordi

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Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site by Andrew R. Pepper, Boris Gala-Lopez, Oliver Ziff, A. M. James Shapiro

“…During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. …”
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Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations by Hirofumi Noguchi

“…Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients. …”
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Variations in Rodent Models of Type 1 Diabetes: Islet Morphology by Lesya Novikova, Irina V. Smirnova, Sonia Rawal, Abby L. Dotson, Stephen H. Benedict, Lisa Stehno-Bittel

“…Type 1 diabetes (T1D) is characterized by hyperglycemia due to lost or damaged islet insulin-producing β-cells. Rodent models of T1D result in hyperglycemia, but with different forms of islet deterioration. …”
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Transduction of TAT/PTD Antiapoptotic Fusion Proteins in Pancreatic Islets by Jennifer Embury, Melina Ribeiro, Dagmar Klein, Antonello Pileggi, R. Damaris Molano, Christopher Fraker, Norma Kenyon, Camillo Ricordi, Luca Inverardi, Ricardo L. Pastori

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The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions by Xinyu Li, Qiang Meng, Lei Zhang

“…However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exhaustion, and immunosuppression-related toxicity that is detrimental to the islet allograft. …”
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Encapsulated human islets in alginate fiber maintain long-term functionality by Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi

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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Paul L. Bollyky, Robert B. Vernon, Ben A. Falk, Anton Preisinger, Michel D. Gooden, Gerald T. Nepom, John A. Gebe

“…Local induction of pro-tolerogenic cytokines, such as IL-10, is an appealing strategy to help facilitate transplantation of islets and other tissues. Here, we describe a pair of implantable devices that capitalize on our recent finding that hyaluronan (HA) promotes IL-10 production by activated T cells. …”
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