Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes by Leslie P. Cousens, Yan Su, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott, Anne S. De Groot

“…Here we evaluate their impact on human immune responses to islet cell antigens ex vivo and on the modulation of type 1 diabetes (T1D) in a murine model in vivo. …”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…Islet transplantation and more recently stem cell-derived islets were shown to successfully re-establish glycemic control in people with type 1 diabetes under immunosuppression. …”
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Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients by Maria Luisa Manca Bitti, Speranza Masala, Francesca Capasso, Novella Rapini, Simona Piccinini, Federica Angelini, Andrea Pierantozzi, Roberta Lidano, Silvia Pietrosanti, Daniela Paccagnini, Leonardo A. Sechi

“…These findings taken together support the hypothesis of MAP as an environmental risk factor for the development of T1D in genetically predisposed subjects, probably involving a mechanism of molecular mimicry between MAP antigens and pancreatic islet β-cells.…”
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Phenylethanoid glycosides from traditional Mongolian medicine Cymbaria daurica alleviate alloxan-induced INS-1 cells oxidative stress and apoptosis by Ruyu Shi, Xing Li, Bing Gao, Chunhong Zhang, Minhui Li

“…C. daurica may play an anti-diabetic role by inhibiting islet cell apoptosis.…”
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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…We found that a certain proportion of Chinese FT1D patients actually have developed islet-related autoantibodies after onset of the disease. …”
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Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes by Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang

“…Moreover, the level of galectin-9 of the OD group was positively correlated with fasting insulin and C-peptide, which were two clinical features that represented pancreatic islet function in T2DM. Conclusions. Our results suggested that TIM3 and galectin-9 may be potential biomarkers related to the pathogenesis of obesity-related T2DM.…”
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Characteristics and Determinants of Partial Remission in Children with Type 1 Diabetes Using the Insulin-Dose-Adjusted A1C Definition by Aurore Pecheur, Thierry Barrea, Valérie Vandooren, Véronique Beauloye, Annie Robert, Philippe A. Lysy

“…Presence of 2 versus 1 anti-islet antibodies correlated with shorter PR. PR duration did not influence occurrence of severe hypoglycemia or diabetes-related complications but was associated with lower A1C levels after 18 months. …”
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Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning by Yue Pang, Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu, Qingwei Li, Guangyi Fan

“…We discovered acinar- and islet-like cell populations despite the lack of parenchymal organs in lampreys, providing evidence of pancreatic function in vertebrates. …”
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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…It has various physiological functions, such as promoting insulin secretion and synthesis, stimulating β-cell proliferation, inducing islet regeneration, inhibiting β-cell apoptosis and glucagon release, delaying gastric emptying and controlling appetite, etc. …”
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SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study by Kunrong Wu, Xiaoli Li, Yuedong Xu, Xiaoqian Zhang, Ziwan Guan, Shufang Zhang, Yan Li

“…The aim of this study was to evaluate if the genetic variants in SLC22A1 rs622342 and ATM rs11212617 could be effective predictors of islet function improvement in patients with type 2 diabetes mellitus (T2DM) on metformin treatment. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…The increase in the CD8+ T-cell infiltration into the tumor islet of Ly6E-KO tumors confirmed the role of Ly6E on T cell exclusion. …”
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A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes by Shuo Lin, Mu Chen, Wanling Chen, Keyi Lin, Panwei Mu, Bilian Zhu, Wen Xu, Manman Wang, Jianping Weng, Longyi Zeng

“…Changes in the C-peptide reactivity index, the secretory unit of islet in transplantation index, and insulin secretion-sensitivity index-2 indicated a greater β-cell function improvement with basal insulin plus OHAs versus CSII. …”
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Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…New cell-based therapy using MSCs for diabetes mellitus is anticipated as an alternative treatment option to insulin injection or islet transplantation in both human and veterinary medicine. …”
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Maternal Diet Supplementation with n-6/n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice by Josiane Morais Martin, Rosiane Aparecida Miranda, Luiz Felipe Barella, Kesia Palma-Rigo, Vander Silva Alves, Gabriel Sergio Fabricio, Audrei Pavanello, Claudinéia Conationi da Silva Franco, Tatiane Aparecida Ribeiro, Jesuí Vergílio Visentainer, Elton Guntendeorfer Banafé, Clayton Antunes Martin, Paulo Cezar de Freitas Mathias, Júlio Cezar de Oliveira

“…MSG-treated mice developed obesity, glucose intolerance, insulin resistance, pancreatic islet dysfunction, and higher fat stores. Maternal flaxseed diet-supplementation decreased n-6/n-3 PUFAs ratio in the brain and pancreas and blocked glucose intolerance, insulin resistance, GIIS impairment, and obesity development. …”
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning by Zuhui Pu, Zuhui Pu, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Lisha Mou, Lisha Mou

“…This study employs single-cell RNA sequencing (scRNA-seq) and machine learning to explore the the pathogenesis of T2D, with a particular focus on immune cell infiltration.MethodsWe analyzed scRNA-seq data from islet cells of T2D and nondiabetic (ND) patients, identifying differentially expressed genes (DEGs), especially those related to metal ion transport (RMITRGs). …”
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Chronic intermittent fasting impairs β cell maturation and function in adolescent mice by Leonardo Matta, Peter Weber, Suheda Erener, Alina Walth-Hummel, Daniela Hass, Lea K. Bühler, Katarina Klepac, Julia Szendroedi, Joel Guerra, Maria Rohm, Michael Sterr, Heiko Lickert, Alexander Bartelt, Stephan Herzig

“…Short-term IF improves glucose homeostasis across all age groups without altering islet function and morphology. In contrast, while chronic IF is beneficial for adult mice, it results in impaired β cell function in the young. …”
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Le travail des peaux et du cuir durant le Haut-Empire à Bordeaux/Burdigala (Gironde), d’après les vestiges mis au jour sur le site de la rue Jean-Fleuret by Vanessa Elizagoyen, Christophe Sireix, Gisèle Allenet de Ribemont, Laurence Benquet, Philippe Borgard, Emilie Claud, Katleen Couchez, Marie-France Dietsch-Sellami, Stéphan Dubernet, Véronique Guitton, Jérôme Hénique, Yannick Le Digol, Martine Leguilloux, Sébastien Lepetz, Fabrice Leroy, Hélène Martin, Alain Queffelec, Stéphanie Raux, Nima Saedlou, Farid Sellami, Laure Simon, Serge Vigier

“…The neighbouring site of Fly Islet, 100 m to the east, then appears to have taken over in terms of craft activity, as indicated by the series of vats comparable to those at Jean-Fleuret, distributed within two spaces separated by a line of wooden stakes and piles perpendicular to the channel and served by a wooden landing stage. …”
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Table for two: Diet composition differences of allopatric and sympatric populations of island geckos by Catarina J. Pinho, Bárbara Santos, Vanessa A. Mata, Ricardo J. Lopes, Maria M. Romeiras, Evandro P. Lopes, Paulo C. Alves, Brent C. Emerson, Raquel Vasconcelos

“…This is exemplified by the two endemic wall geckos, Tarentola gigas and Tarentola raziana, which occur in sympatry on Raso Islet, with the latter also occurring in allopatry on Santa Luzia Island, due to the human-mediated extinction of T. gigas. …”
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Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice by Jing Xue, Yu Cheng, Haojie Hao, Jieqing Gao, Yaqi Yin, Songyan Yu, Junyan Zou, Jiejie Liu, Qi Zhang, Yiming Mu

“…Immunofluorescence staining demonstrated more sustainable morphological and structural amelioration in islets of the MD group than in the MSC group. Interestingly, further analysis showed more alternatively activated macrophages (M2, anti-inflammatory) and fewer classically activated macrophages (M1, proinflammatory) in islets of the MD group 4 weeks after treatment. …”
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Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring by Abdel-Baset M. Aref, Osama M. Ahmed, Lobna A. Ali, Margit Semmler

“…Vacuolation and necrosis of the islets of Langerhans were also observed throughout the experimental period. …”
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