Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…EMPA-treated T1D mice had higher islet density, with preserved architecture, compared to T1D mice, and EMPA-treated T1D mice also differed from T1D mice by the total absence of immune cell infiltration within islets. …”
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Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children by Lian-Ping He, Yu-Xin Song, Ting Zhu, Wei Gu, Chang-Wei Liu

“…Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β cells damaged, resulting in an absolute lack of insulin, ultimately relying on insulin therapy. …”
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Adipose Tissue-Derived Mesenchymal Stem Cells Exert In Vitro Immunomodulatory and Beta Cell Protective Functions in Streptozotocin-Induced Diabetic Mice Model by Hossein Rahavi, Seyed Mahmoud Hashemi, Masoud Soleimani, Jamal Mohammadi, Nader Tajik

“…In conclusion, it seems that MSCs may provide a new horizon for T1DM cell therapy and islet transplantation in the future.…”
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Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model by Xuehai Chen, Jiao Luo, Minmin Wu, Zhuo Pan, Yue Xie, Hongwei Wang, Bicheng Chen, Hong Zhu

“…Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. …”
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The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner by Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Anzu Matsumura, Daisuke Miyashita, Kuniyuki Nishiyama, Yusuke Takano, Yu Togashi, Makiko Meguro-Horike, Shin-ichi Horike, Tatsuya Kin, A.M. James Shapiro, Hiromi Yanagisawa, Yasuo Terauchi, Jun Shirakawa

“…Summary: The matricellular protein Fibulin-5 (Fbln5) is a secreted protein that is essential for elastic fiber formation, and pancreatic islets are usually surrounded by the extracellular matrix (ECM), which includes elastic fibers. …”
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Therapeutic effects of resveratrol and β-carotene on L-arginine-induced acute pancreatitis through oxidative stress and inflammatory pathways in rats by Arzu Gezer, Hilal Üstündağ, Mustafa Özkaraca, Ebru Karadağ Sari, Cihan Gür

“…The AP + RES and AP + βC groups exhibited preserved β + Langerhans islet size (p < 0.01), suppressed NF-κB, TNF-α, and IL-1β expression, reduced Bax and Caspase-3 levels, and increased Bcl-2 levels (p < 0.01). …”
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Administration of a Next-Generation Probiotic Escherichia coli Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes by Jie Luo, Yilin Fang, Zhanghua Qi, Fengyang Cui, Hong Hu, Shengjie Li, Tingtao Chen, Hongyan Zhang

“…Similarly, EcN-GLP-1 had a pronounced impact on T2DM mice, manifesting increased presence of islet β-cells, decreased inflammatory response and apoptosis, and regulation of lipid metabolism in the liver. …”
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Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models by Long Cheng, Xiang-bao Meng, Shan Lu, Ting-ting Wang, Yue Liu, Gui-bo Sun, Xiao-bo Sun

“…After 4 weeks, TNTL intervention in STZ-induced diabetic rats yielded in significant improvement on the glucose tolerance test. Moreover, the islet histopathology showed that oral TNTL reduced the severity of islet necrosis in pancreases tissue. …”
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Mesenchymal Stem Cells Ameliorate Hyperglycemia in Type I Diabetic Developing Male Rats by Hany N. Yousef, Samia M. Sakr, Sahar A. Sabry

“…These biochemical alterations were confirmed by the histopathological and ultrastructural assessments which showed marked destructive effect on pancreatic islet cells. MSC therapy in an early stage reversed most of the biochemical, histological, and ultrastructural alterations in the STZ-induced diabetic model and restored the normal cellular population of most acinar cells and islet of Langerhans. …”
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Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome by Usman H. Malabu, Durgesh Gowda, Yong Mong Tan

“…We describe a 34-year-old male with clinical, laboratory, and radiologic data consistent with islet cell tumor and seminiferous tubule failure primary hypogonadism. …”
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Nonalcoholic Fatty Liver Disease: Its Mechanisms and Complications by Abdelfattah El Ouaamari, Kaori Minehira

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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). …”
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Identification of a pancreatic stellate cell gene signature and lncRNA interactions associated with type 2 diabetes progression by Jinjun Qiu, Peng Zhu, Peng Zhu, Xing Shi, Jinquan Xia, Shaowei Dong, Liqun Chen

“…This study aims to identify gene expression patterns specific to T2D pancreatic islet cells and to explore the potential role of pancreatic stellate cells (PSCs) in T2D progression through regulatory networks involving lncRNA-mRNA interactions.MethodsIn this study, we screened for upregulated genes in T2D pancreatic islet samples using bulk sequencing (bulkseq) datasets and mapped these gene expression profiles onto three T2D single-cell RNA sequencing (scRNAseq) datasets. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Glutamic acid decarboxylase autoantibodies, zinc transporter 8 autoantibodies, insulin autoantibodies, islet antigen 2 autoantibodies, and islet cell antibodies were all negative. …”
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Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers by Zhenyu Qian, Yan Jia, Guanghong Wei

“…Increasing evidence suggests that the interaction of human islet amyloid polypeptide (hIAPP) with lipids may facilitate hIAPP aggregation and cause the death of pancreatic islet β-cells. …”
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Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats by Louiza Belkacemi, Ghalem Selselet-Attou, Emeline Hupkens, Evrard Nguidjoe, Karim Louchami, Abdullah Sener, Willy J. Malaisse

“…The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. …”
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Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent Diabetic Children by Yasar Dogan, Saadet Akarsu, Bilal Ustundag, Erdal Yilmaz, Metin Kaya Gurgoze

“…T cells are activated in response to islet-dominant autoantigens, the result being the development of IDDM. …”
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Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer by Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang

“…Taken together, SLC24A2 may link T2D and cancer by influencing the ribosome function of islet β cells and play different prognostic roles in different cancers.…”
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The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure. …”
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On Architecture and Landscape. Some Fragmentary Representations by Alberto Grijalba Bengoetxea, Julio Grijalba Bengoetxea

“… Between 1928 and 1929, Sigurd Lewerentz designed and built Theodor Anton Bergen’s tomb on the islet Utterö, in an archipelago near Stockholm that can only be reached by boat. …”
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