Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

“…A case report is presented in which a type-II diabetic patient significantly improved his dysfunctional β-islet cells using a combination of a strenuous exercise program, cyclical ketogenic diet, and oral GABA/probiotic supplementation. …”
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Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…Recently, a low level of insulin has been found in non-β islet cells of patients with longstanding T1D, indicating that other islet cell types may contribute to persistent insulin secretion. …”
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Evaluation of Ex-Vivo Gene Transfer of Fadd-Dn to Pancreatic Islets by Elizabeth S. Fenjves, Maria S. Ochoa, Thierry Barney, Damaris Molano, Antonello Pileggi, Camillo Ricordi, Luca Inverardi

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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Prolonged exposure to GIPR agonists produced homologous functional GIPR desensitisation in isolated islets. GIP108 pre-treatment in vivo also reduced the subsequent anti-hyperglycaemic response to GIP re-challenge. …”
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Can Islet Transplantation Possibly Reduce Mortality in Type 1 Diabetes by Jeffrey S. Isenberg, Fouad Kandeel

“…Islet transplantation (IT) is a successful natural cell therapy. …”
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An unmet need: Pancreatic beta cell replacement by F Mohamed, C Adams, B Mansfield

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Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication by Jide Tian, Hoa Dang, Angela Hu, Willem Xu, Daniel L. Kaufman

“…This study tested the hypothesis that lesogaberan could be repurposed to promote human islet cell survival and β-cell replication. Treatment with lesogaberan significantly enhanced replication of human islet cells in vitro, which was abrogated by a GABAB-R antagonist. …”
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Eugenol Improves Insulin Secretion and Content of Pancreatic Islets from Male Mouse by Ali Akbar Oroojan

“…So, it was decided to investigate the effect of eugenol on the insulin secretion and content of pancreatic islets from the male mice. In this experimental study, 3-month-old NMRI mice (20–25 g) were prepared. …”
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Iodixanol Density Gradient Preparation in University of Wisconsin Solution for Porcine Islet Purification by Michael P.M. Van der Burg, John M. Graham

“…Previously published as Graham, J.M. (2002) Purification of Islets of Langerhans from porcine pancreas. TheScientificWorldJOURNAL 2, 1657–1661. …”
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Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen by Gokhan Duruksu, Aysegul Aciksari

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In Vitro Proliferation of Porcine Pancreatic Islet Cells for β-Cell Therapy Applications by Guoguang Niu, John P. McQuilling, Yu Zhou, Emmanuel C. Opara, Giuseppe Orlando, Shay Soker

“…Islets were isolated from porcine pancreases and enzymatically digested to dissociate the component cells. …”
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Increased Yield and Improved Transplantation Outcome of Mouse Islets with Bovine Serum Albumin by Suzanne Bertera, A. N. Balamurugan, Rita Bottino, Jing He, Massimo Trucco

“…Isolation and transplantation of rodent islets are frequently used as a tool for predicting the behavior of new protocols for islet allotransplants in type 1 diabetes patients. …”
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The Effects Of Simvastatin On Islets Of Langerhans In The Pancreas Of Rats: A Histological And Biochemical Study by Abdullah Qamar, Hammad Gul Khan, Hina Kundi, Ayesha Ali, Sumyyia Bashir, Tooba Khurshid

“… Objective: This study explored the effect of simvastatin on the histomorphology of islets of Langerhans, glucose and insulin levels in rats. …”
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Evolution of 𝜷-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation by Cyrus Jahansouz, Cameron Jahansouz, Sean C. Kumer, Kenneth L. Brayman

“…In this paper, the historical evolution, procurement, current status, benefits, risks, and ongoing research of islet cell transplantation are explored.…”
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Antibodies to Lactobacilli and Bifidobacteria in Young Children with Different Propensity to Develop Islet Autoimmunity by Ija Talja, Anna-Liisa Kubo, Riitta Veijola, Mikael Knip, Olli Simell, Jorma Ilonen, Mari Vähä-Mäkilä, Epp Sepp, Marika Mikelsaar, Meeme Utt, Raivo Uibo

“…We measured IgG, IgM, and IgA class antibody reactivity against B. adolescentis DSM 20083, B. adolescentis DSM 20086, and B. longum DSM 20088 proteins demonstrating significantly higher IgA responses against B. adolescentis DSM 20083 strain proteins in children who developed islet autoimmunity and T1D later in life. B. adolescentis strains showed more IgM type antibodies in children who developed T1D later in life, but the difference was not statistically significant. …”
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Synergistic Effect of Hyperglycemia and Suppression on Adult Mouse Islet Beta Cell Replication by Szu-Tah Chen, Shin-Huei Fu, Samuel Hsu, Yu-Yao Huang, Brend Ray-Sea Hsu

“…At 54 hours after viral infection, protein content in cultured targeting islets was 22% of that in freshly isolated islets. …”
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Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes by Hiroshi Nomoto, Tatyana Gurlo, Madeline Rosenberger, Mark D. Girgis, Sarah Dry, Peter C. Butler

“…There was patchy low grade immune infiltration in some, but not all, islets that met criteria for autoimmune insulitis. …”
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Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes by Rebecca Craig-Schapiro, Ge Li, Kevin Chen, Jesus M. Gomez-Salinero, Ryan Nachman, Aleksandra Kopacz, Ryan Schreiner, Xiaojuan Chen, Qiao Zhou, Shahin Rafii, David Redmond

“…Here, we develop strategies to enrich islet-specific endothelial cells (ISECs) and acinar-specific endothelial cells (ASECs) from three human pancreases and corroborate these findings with three published pancreatic datasets. …”
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Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis by Ang Liang, Jinglong Liu, Zhiyuan Zhang, Jing Xiao, Dezeng Liu, Zimei Dong, Guangwen Chen

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Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

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