Discrete Coupling and Synchronization in the Insulin Release in the Mathematical Model of the β Cells by L. J. Ontañón-García, E. Campos-Cantón

“…The synchronization phenomenon that occurs in the Langerhans islets among pancreatic β cells is an interesting topic because these cells are responsible for the release of insulin in the blood stream. …”
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Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin by Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola

“…In this study, we confirmed the expression of TREK-1 channels in the insulin secreting MIN6-B1 β-cell line and in mouse islets. We found that their blockade by SPA potentiated insulin secretion induced by potassium chloride dependent membrane depolarization. …”
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The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) by Shin Takasawa, Tomoko Uchiyama, Maiko Takeda

“…Regenerating gene (Reg) was first isolated in 1988 and proposed to be specifically expressed in rat regenerating pancreatic islets. Since then, many genes homologous to Reg have been discovered in other species, including humans, mice, hamsters, rabbits, sheep, dogs, cats, pigs, giant pandas, chickens, and frogs. …”
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Genetic, Functional, and Immunological Study of ZnT8 in Diabetes by Qiong Huang, Jie Du, Chengfeng Merriman, Zhicheng Gong

“…The highest zinc concentration is in the pancreas islets. Zinc accumulation in cell granules is manipulated by ZnT8, a zinc transporter expressed predominately in pancreatic α and β cells. …”
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Azores UNESCO Global Geopark: Where Volcanoes Tell us their Stories by Eva Lima, Salomé Meneses

“…The Azores UNESCO Global Geopark, located in the North Atlantic Ocean is a volcanic archipelago with several non-inhabited islets and nine inhabited islands. The 27 volcanic systems with polygenetic central volcanoes and volcanic ridges, most of them active but dormant, represent an exuberant geological heritage, most of which (77% of geosites) is protected. …”
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Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway by Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong Ma

“…Here we tested FLZ, a synthetic derivative of squamosamide from a Chinese herb, as a potential candidate for antiglucotoxicity in INS-1E cells and mouse islets. Chronic culture of β-cells in 30 mM glucose caused progressive reduction of cell viability, accompanied with increased apoptosis and reduced insulin secretion. …”
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The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization. by Martin Sztacho, Jakub Červenka, Barbora Šalovská, Ludovica Antiga, Peter Hoboth, Pavel Hozák

“…Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and is involved in RNA polymerase I/II transcription. …”
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Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes by Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede

“…Increasing Cab45G biosynthesis leads to anterograde trafficking into insulin granules, stimulating their production. Using human donor islets, we identify increased anterograde Cab45G trafficking in obese humans with and without T2D, consistent with the heightened demand for granule biogenesis. …”
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Unveiling nature’s antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats by Ali Imran Abid, Hira Muzammel, Mohsin Javed, Muhammad Muntazir Iqbal, Sajid Mahmood, Ammar Zidan, Fadi Jaber, K. K. Mujeeb Rahman, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Ayed A. Dera, Yousif A. Asiri, Abd-ElAziem Farouk, Salman Aloufi

“…Serum lipid measurements showed a substantial reduction in triglycerides and total cholesterol on days 7 and 15. The pancreas’s islets were protected by the extract, as shown by a histological analysis. …”
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Type 1 Diabetes (T1D) and Latent Autoimmune Diabetes in Adults (LADA): The Difference Between a Honeymoon and a Holiday by Livia M. R. Marcon, Carmine G. Fanelli, Riccardo Calafiore

“…Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease in which destruction of the insulin-producing β-cells in the pancreatic islets requires regular lifelong insulin replacement therapy, the only lifesaving treatment available at this time. …”
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Je parle pas la langue 1 by Noëlle MATHIS

“…It reads like an archipelago of fragments to be visited, like islets of (ac)knowledge(ment). It cuts a path in the silent hollows of writing and forgetting across several landscapes. …”
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Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats by Xin Xiao, Ochuko L. Erukainure, Md. Shahidul Islam

“…Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. …”
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Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells by Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Mars G. Sharapov, Vladimir I. Novoselov, Evgeny E. Fesenko

“…It was shown that PRDX6 prevented hyperglycemia, lowered the mortality rate, restored the plasma cytokine profile, reversed the splenic cell apoptosis, and reduced the β cell destruction in Langerhans islets in mice with a severe form of alloxan-induced diabetes. …”
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JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diab... by Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta

“…Furthermore, pancreatic protection effects, such as an increase in pancreatic weight and an elevation of insulin-positive area in islets, were observed after JTT-130 treatment. Conclusions. …”
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Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats by Lukáš Alán, Tomáš Olejár, Monika Cahová, Jaroslav Zelenka, Zuzana Berková, Magdalena Smětáková, František Saudek, Radoslav Matěj, Petr Ježek

“…Reduced beta cell mass in pancreatic islets (PI) of Goto-Kakizaki (GK) rats is frequently observed in this diabetic model, but knowledge on delta cells is scarce. …”
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Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis by Tanya S. McDonald, Cedric S. Cui, Titaya Lerskiatiphanich, Jianina Marallag, John D. Lee

“…We also examined plasma hormone levels and quantified α- and β-cell areas in pancreatic islets. Throughout disease progression, TDP-43Q331K mice exhibited elevated metabolic rates, with a transient increase in food intake at the early stages. …”
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Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study by Du-Bois Asante, Emmanuel Effah-Yeboah, Precious Barnes, Heckel Amoabeng Abban, Elvis Ofori Ameyaw, Johnson Nyarko Boampong, Eric Gyamerah Ofori, Joseph Budu Dadzie

“…Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.…”
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Impaired Glucose Metabolism in Young Offspring of Female Rats with Hypothyroidism by Zhoujun Liu, Yu Chen, Guofang Chen, Xiaodong Mao, Xiao Wei, Xingjia Li, Yijiao Xu, Fan Jiang, Kun Wang, Chao Liu

“…Our results showed that there were no differences of islets structure between the offspring from the two groups, but glucose metabolism was impaired with higher plasma glucose concentrations at 0 and 15 min in the OGTT in 8-week-old offspring of the MH group. …”
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The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice by Petrus Mantur, Efrisca Meliyuita Br. Damanik, Elisabeth Levina Sari Setianingrum, Prisca Pakan

“…Histopathological imaging revealed a significant improvement in b cell distribution and decreased vacuolization in the Langerhans islets of mice administered lemon extract. No significant differences were observed among  different dosages of lemon extract (p>0.05). …”
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Heterotopic Pancreas in the Gallbladder: Case Report and Literature Review by Emad Aborajooh, Ibrahim Khalil Khairi Ghayada, Yasser Mustafa Issa Lafi

“…Microscopic examination of the gallbladder showed that a heterotopic pancreatic tissue, composed of a large number of pancreatic acini and few ducts with the absence of islets of Langerhans, was found around the cystic duct. …”
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