Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study by Jie Yang, Wenna Wang, Yizhen Lu, Chunyao Li, Shuwu Wei, Weiwei Sun

“…Conclusions Age and eGFR < 60 ml/min/1.73m2 were independent risk factors for pulmonary nodules in patients with T2DM, and overweight may be a protective factor. Moreover, decreased islet B-cell function and smoking may contribute to the presence of PNs with a diameter of over 5 mm.…”
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Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat by Ghupurjan Gheni, Norihide Yokoi, Masayuki Beppu, Takuro Yamaguchi, Shihomi Hidaka, Ayako Kawabata, Yoshikazu Hoshino, Masayuki Hoshino, Susumu Seino

“…In nondiabetic Zucker fatty (ZF) rats, the insulin secretory responses to both glucose stimulation and the incretin in the pancreatic islets were similar to those of ZFDM rats. As islet architecture was destroyed with age in ZFDM rats, a combination of severe insulin resistance, diminished insulin secretory response to incretin, and intrinsic fragility of the islets may cause the development of T2D in this strain.…”
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Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes by Leslie P. Cousens, Yan Su, Elizabeth McClaine, Xin Li, Frances Terry, Robert Smith, Jinhee Lee, William Martin, David W. Scott, Anne S. De Groot

“…Here we evaluate their impact on human immune responses to islet cell antigens ex vivo and on the modulation of type 1 diabetes (T1D) in a murine model in vivo. …”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…Islet transplantation and more recently stem cell-derived islets were shown to successfully re-establish glycemic control in people with type 1 diabetes under immunosuppression. …”
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Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients by Maria Luisa Manca Bitti, Speranza Masala, Francesca Capasso, Novella Rapini, Simona Piccinini, Federica Angelini, Andrea Pierantozzi, Roberta Lidano, Silvia Pietrosanti, Daniela Paccagnini, Leonardo A. Sechi

“…These findings taken together support the hypothesis of MAP as an environmental risk factor for the development of T1D in genetically predisposed subjects, probably involving a mechanism of molecular mimicry between MAP antigens and pancreatic islet β-cells.…”
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Phenylethanoid glycosides from traditional Mongolian medicine Cymbaria daurica alleviate alloxan-induced INS-1 cells oxidative stress and apoptosis by Ruyu Shi, Xing Li, Bing Gao, Chunhong Zhang, Minhui Li

“…C. daurica may play an anti-diabetic role by inhibiting islet cell apoptosis.…”
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Hypoglycemic Effects and Myocardial Protection of Sanghuangporus vaninii Polysaccharide on Diabetes Rats by Yue CHANG, Yue WU, Jianfeng GUO, Weiyuan ZHAO, Yuantian LU, Di LIU

“…HE staining revealed a significant increase in the number of pancreatic islet cells in SP group rats than in the DM group rats, and the cells were more complete. …”
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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…We found that a certain proportion of Chinese FT1D patients actually have developed islet-related autoantibodies after onset of the disease. …”
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Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes by Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang

“…Moreover, the level of galectin-9 of the OD group was positively correlated with fasting insulin and C-peptide, which were two clinical features that represented pancreatic islet function in T2DM. Conclusions. Our results suggested that TIM3 and galectin-9 may be potential biomarkers related to the pathogenesis of obesity-related T2DM.…”
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EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents by Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Olga Kordonouri, Agnieszka Szypowska, Ezio Bonifacio, Parth Narendran, Christiane Winkler, R Ribeiro, Sandra Hummel, Przemysława Jarosz-Chobot, Emanuele Bosi, R Lahesmaa, K Casteels, M Peakman, P Jarosz-Chobot, O Kordonouri, Chantal Mathieu, Vito Lampasona, J F Raposo, H Hyöty, F Pociot, João Filipe Raposo, R Berner, R Bergholdt, E Bonifacio, Flemming Pociot, B Petersen, J Van Rampelbergh, L Overbergh, B Van der Schueren, V Lampasona, C Winkler, R Coelho, O Cohen, C Mathieu, E Bosi, Stefanie Arnolds, Lut Overbergh, Zdenek Sumnik, A Koralova, G Sebastiani, Luisa Hoffmann, Mirjam Kohls, Regine Bergholdt, Bianca K Hoefelschweiger, Jurgen Vercauteren, P Gillard, J Vercauteren, A G Ziegler, P Achenbach, F Haupt, S Hummel, T Pieber, J Mader, S Moitzi, S Del Prato, B Torbeyns, Z Sumnik, O Cinek, V Neuman, B Berka, J Antvorskov, J H Klaebel, J E Laiho, F Reschke, T von dem Berge, A Hommel, A Loff, G Gemulla, N Zubizarreta, L Piemonti, F Dotta, A Szypowska, K Karczewski, E Niemoeller, M Baccara-Dinet, K Fogh, M I Buompensiere, C Hurtado del Pozo, E Latres, G Agiostratidou

“…Screening is performed in capillary blood, examining different islet autoantibodies (autoantibodies against insulin, glutamic acid decarboxylase-65, insulinoma-associated antigen-2 and/or zinc transporter-8). …”
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Characteristics and Determinants of Partial Remission in Children with Type 1 Diabetes Using the Insulin-Dose-Adjusted A1C Definition by Aurore Pecheur, Thierry Barrea, Valérie Vandooren, Véronique Beauloye, Annie Robert, Philippe A. Lysy

“…Presence of 2 versus 1 anti-islet antibodies correlated with shorter PR. PR duration did not influence occurrence of severe hypoglycemia or diabetes-related complications but was associated with lower A1C levels after 18 months. …”
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Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning by Yue Pang, Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu, Qingwei Li, Guangyi Fan

“…We discovered acinar- and islet-like cell populations despite the lack of parenchymal organs in lampreys, providing evidence of pancreatic function in vertebrates. …”
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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…It has various physiological functions, such as promoting insulin secretion and synthesis, stimulating β-cell proliferation, inducing islet regeneration, inhibiting β-cell apoptosis and glucagon release, delaying gastric emptying and controlling appetite, etc. …”
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Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes by Desmond Schatz, Laura Jacobsen, Todd M Brusko, Michael J Haller, Mark Atkinson, MacKenzie D Williams, Catherine Ramsey Grace, Amanda L Posgai, Kieran M McGrail, Maigan A Brusko, Rhonda Bacher, Clive H Wasserfall

“…We collectively evaluated seven such biomarkers, combined with islet autoantibodies (AAb) and genetic risk score (GRS2), for their utility in predicting AAb/T1D status.Research design and methods Cross-sectional serum samples (n=154 T1D, n=56 1AAb+, n=77 ≥2AAb+, n=256 AAb−) were assessed for IGF1, IGF2, adiponectin, leptin, amylase, lipase, and trypsinogen (n=543, age range 2.7–30.0 years) using random forest modeling.Results GRS2, age, lipase, trypsinogen, and AAb against ZnT8, GAD65, and insulin were the most informative markers. …”
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NAFPD exacerbation by hyperlipidemia combined with hyperuricemia: a pilot rat experiment in lipidomics by Jingyun Li, Jingyun Li, Yongjian Chen, Shilin Li, Guorong Lyu, Guorong Lyu, Furong Yan, Jiajing Guo, Jing Cheng, Yun Chen, Jiaojiao Lin, Yating Zeng

“…HE staining revealed that most rats in the CON group exhibited normal pancreatic islet and acinar cell morphology. The pathological NAFPD score in the PH group was higher than that in the PO group. …”
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SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study by Kunrong Wu, Xiaoli Li, Yuedong Xu, Xiaoqian Zhang, Ziwan Guan, Shufang Zhang, Yan Li

“…The aim of this study was to evaluate if the genetic variants in SLC22A1 rs622342 and ATM rs11212617 could be effective predictors of islet function improvement in patients with type 2 diabetes mellitus (T2DM) on metformin treatment. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…The increase in the CD8+ T-cell infiltration into the tumor islet of Ly6E-KO tumors confirmed the role of Ly6E on T cell exclusion. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

“…A meal tolerance test (MTT) was conducted on seven of these patients to assess parameters associated with islet function or insulin tolerance, such as homeostasis model assessment (HOMA)-β-cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR), C-peptide immunoreactivity (CPR) index, and glucagon kinetics. …”
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A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes by Shuo Lin, Mu Chen, Wanling Chen, Keyi Lin, Panwei Mu, Bilian Zhu, Wen Xu, Manman Wang, Jianping Weng, Longyi Zeng

“…Changes in the C-peptide reactivity index, the secretory unit of islet in transplantation index, and insulin secretion-sensitivity index-2 indicated a greater β-cell function improvement with basal insulin plus OHAs versus CSII. …”
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Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…New cell-based therapy using MSCs for diabetes mellitus is anticipated as an alternative treatment option to insulin injection or islet transplantation in both human and veterinary medicine. …”
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