The Insulin Regulatory Network in Adult Hippocampus and Pancreatic Endocrine System by Masanao Machida, Shin Fujimaki, Ryo Hidaka, Makoto Asashima, Tomoko Kuwabara

“…Hormonal signals from the pancreatic islets influence the regulation of energy homeostasis by the brain, and the brain in turn influences the secretions of the islets. …”
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Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment by Karsten Buschard, Laurits J. Holm, Ulla Feldt-Rasmussen

“…Fenofibrate reverses and prevents autoimmune diabetes in nonobese diabetic (NOD) mice by increasing the amount of the sphingolipid sulfatide in islets. Sphingolipid metabolism is otherwise abnormal in the islets at diagnosis of type 1 diabetes. …”
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FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells by Xiangchen Kong, Bingfeng Li, Yushen Deng, Xiaosong Ma

“…We now show that ADCY8 expression is decreased in Goto-Kakizaki (GK) rat islets compared with healthy Wistar controls. We also found that reduced ADCY8 is associated with decreased expression of FXR. …”
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…Methods: We evaluated Lgr4 expression in mouse and human islets in response to acute (proinflammatory cytokines), or chronic (high fat fed mice, db/db mice, and aging) stress. …”
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The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells by Magdalena Maj, Gregor Hoermann, Sazan Rasul, Wolfgang Base, Ludwig Wagner, Johannes Attems

“…We have previously shown that MAPT is present in human islets of Langerhans, human insulinomas, and pancreatic beta-cell line models, with biophysical similarities to the pathological MAPT in the brain. …”
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Handle Region Peptide Ameliorating Insulin Resistance but Not β Cell Functions in Male Rats Neonatally Treated with Sodium L-Glutamate by Guo-shu Yin, Shao-da Lin, Dong-chuan Xu, Ru-qiong Sun, Kun Lin, Chu-jia Lin

“…On the other hand, losartan but not HRP decreased α-cell mass and number of PCNA-positive cells located periphery of the islets and decreased picrosirius red stained area in islets. …”
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Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal islets. The dysfunctional pathways, the potential transcription factor, and microRNA targets were analyzed by bioinformatics methods. …”
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Influential Factors of the Static Shear Properties of Coral Mud in the South China Sea by Yang Shen, Xiaoxi Rui, Long Yang, Shaoyu Li, Xue Shen

“…Coral mud, a kind of special material used for constructing islets in reclamation projects, is widely spread in the South China Sea. …”
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Parents voyageurs. Croisières familiales au long cours by Anne Gaugue

“…Be it oceanic areas or tropical islets, parental supervision also varies according to the place frequented.…”
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Recombinant Lactococcus lactis Carrying IL-4 and IL-10 Coding Vectors Protects against Type 1 Diabetes in NOD Mice and Attenuates Insulitis in the STZ-Induced Model by Tatiane M. Preisser, Vanessa P. da Cunha, Mariana P. Santana, Vanessa B. Pereira, Denise C. Cara, Bianca M. Souza, Anderson Miyoshi

“…The STZ-induced mice that were treated with combined bacterial strains carrying plasmids encoding IL-4 and IL-10 showed lower incidence of diabetes and more preserved pancreatic islets than the mice that received the individual bacterial strains. …”
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Discrete Coupling and Synchronization in the Insulin Release in the Mathematical Model of the β Cells by L. J. Ontañón-García, E. Campos-Cantón

“…The synchronization phenomenon that occurs in the Langerhans islets among pancreatic β cells is an interesting topic because these cells are responsible for the release of insulin in the blood stream. …”
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Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin by Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola

“…In this study, we confirmed the expression of TREK-1 channels in the insulin secreting MIN6-B1 β-cell line and in mouse islets. We found that their blockade by SPA potentiated insulin secretion induced by potassium chloride dependent membrane depolarization. …”
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The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) by Shin Takasawa, Tomoko Uchiyama, Maiko Takeda

“…Regenerating gene (Reg) was first isolated in 1988 and proposed to be specifically expressed in rat regenerating pancreatic islets. Since then, many genes homologous to Reg have been discovered in other species, including humans, mice, hamsters, rabbits, sheep, dogs, cats, pigs, giant pandas, chickens, and frogs. …”
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Genetic, Functional, and Immunological Study of ZnT8 in Diabetes by Qiong Huang, Jie Du, Chengfeng Merriman, Zhicheng Gong

“…The highest zinc concentration is in the pancreas islets. Zinc accumulation in cell granules is manipulated by ZnT8, a zinc transporter expressed predominately in pancreatic α and β cells. …”
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Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway by Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong Ma

“…Here we tested FLZ, a synthetic derivative of squamosamide from a Chinese herb, as a potential candidate for antiglucotoxicity in INS-1E cells and mouse islets. Chronic culture of β-cells in 30 mM glucose caused progressive reduction of cell viability, accompanied with increased apoptosis and reduced insulin secretion. …”
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Type 1 Diabetes (T1D) and Latent Autoimmune Diabetes in Adults (LADA): The Difference Between a Honeymoon and a Holiday by Livia M. R. Marcon, Carmine G. Fanelli, Riccardo Calafiore

“…Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease in which destruction of the insulin-producing β-cells in the pancreatic islets requires regular lifelong insulin replacement therapy, the only lifesaving treatment available at this time. …”
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Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes by Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede

“…Increasing Cab45G biosynthesis leads to anterograde trafficking into insulin granules, stimulating their production. Using human donor islets, we identify increased anterograde Cab45G trafficking in obese humans with and without T2D, consistent with the heightened demand for granule biogenesis. …”
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Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats by Xin Xiao, Ochuko L. Erukainure, Md. Shahidul Islam

“…Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. …”
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Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells by Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Mars G. Sharapov, Vladimir I. Novoselov, Evgeny E. Fesenko

“…It was shown that PRDX6 prevented hyperglycemia, lowered the mortality rate, restored the plasma cytokine profile, reversed the splenic cell apoptosis, and reduced the β cell destruction in Langerhans islets in mice with a severe form of alloxan-induced diabetes. …”
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JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diab... by Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta

“…Furthermore, pancreatic protection effects, such as an increase in pancreatic weight and an elevation of insulin-positive area in islets, were observed after JTT-130 treatment. Conclusions. …”
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