Association of intraprocedural near admission-level blood pressure with functional outcome in stroke patients treated with mechanical thrombectomy by Min Chen, Lukas Daniel Sauer, Mika Herwig, Jessica Jesser, Meinhard Kieser, Arne Potreck, Markus Möhlenbruch, Peter Arthur Ringleb, Silvia Schönenberger

“…Methods We conducted a retrospective observational study at a single center at a university hospital, which included patients from August 2018 to September 2020 suffering from acute ischemic stroke with anterior circulation vessel occlusion and treated with endovascular therapy. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time points following mouse cerebral ischemia. …”
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Stroke Risk among Patients with Type 2 Diabetes Mellitus in Zhejiang: A Population-Based Prospective Study in China by Lihua Guo, Min Yu, Jieming Zhong, Haibin Wu, Jin Pan, Weiwei Gong, Meng Wang, Fangrong Fei, Ruying Hu

“…Stroke subtypes were classified according to standard definitions of subarachnoid hemorrhage, intracerebral hemorrhage, and ischemic stroke. The incidence of stroke and stroke subtypes was calculated by standardized incidence ratio (SIRs) with 95% confidence intervals (CIs) compared with general population. …”
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Cryopreservation of Bone Marrow Mononuclear Cells Alters Their Viability and Subpopulation Composition but Not Their Treatment Effects in a Rodent Stroke Model by Bing Yang, Kaushik Parsha, Krystal Schaar, Nikunj Satani, Xiaopei Xi, Jaroslaw Aronowski, Sean I. Savitz

“…The systemic administration of autologous bone marrow (BM) derived mononuclear cells (MNCs) is under investigation as a novel therapeutic modality for the treatment of ischemic stroke. Autologous applications raise the possibility that MNCs could potentially be stored as a banked source. …”
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Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Well-Recovered Stroke Patients by Wei Li, Tong Han, Wen Qin, Jing Zhang, Huaigui Liu, Ying Li, Liangliang Meng, Xunming Ji, Chunshui Yu

“…In the present study, we aimed to investigate the resting-state functional connectivity (rsFC) changes in 25 subcortical ischemic stroke patients with well-recovered global motor function. …”
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The Risk Factors of Self-Management Behavior among Chinese Stroke Patients by Huang Shuqi, Li Siqin, Wu Xiaoyan, Yang Rong, Zhao Lihong

“…Stroke is associated with a high number of disability-adjusted life years globally, so long-term care is necessary and important for those survivors, so self-management is becoming a more significant concept in stroke rehabilitation. Methods. Ischemic stroke patients (n = 354) were enrolled from the outpatient department of Neurology in West China Hospital from September 2018 to December 2019. …”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Furthermore, we present the role of PGC-1α in the pathogenesis of various neurological diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, and other PolyQ diseases. …”
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Safety and efficacy of apixaban versus vitamin K antagonists in patients undergoing dialysis: a systematic review and meta-analysis by Yifang Zhang, Jialiang Wang, Nannan Shen, Jie Jiang, Yanna Xie

“…Meta-analysis showed no difference in the risk of ischemic stroke (RR: 0.40, 95% CI: 0.06, 2.69, I2 = 0%), mortality (RR: 1.26, 95% CI: 0.74, 2.16, I2 = 94%) and recurrent venous thromboembolism (RR: 1.02, 95% CI: 0.87, 1.21, I2 = 0%) between the two groups. …”
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The Adverse Effect of Spasticity on 3-Month Poststroke Outcome Using a Population-Based Model by S. R. Belagaje, C. Lindsell, C. J. Moomaw, K. Alwell, M. L. Flaherty, D. Woo, K. Dunning, P. Khatri, O. Adeoye, D. Kleindorfer, J. Broderick, B. Kissela

“…Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Rankin Score (mRS) as an indicator of functional outcome. …”
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Risk Factors for Hemorrhagic Stroke among Adults in the Democratic Republic of the Congo: A Hospital-Based Study in a Limited Resource Setting by Jacques Mbaz Musung, Placide Kambola Kakoma, Marcellin Bugeme, Jeef Paul Munkemena Banze, Clarence Kaut Mukeng, Orly Ngungwa Muyumba, Berthe Mwad Kamalo, Harvey Kabulo Kapya, Ghyslain Lambo Ngongo, Laurent Kitwa, Evariste Tshibind Yav, Olivier Mukuku, Emmanuel Kiyana Muyumba

“…Of 9,919 hospitalized patients, 158 had a stroke with a hospital prevalence of 1.6%; 86 (54.4%) patients had a hemorrhagic stroke while 72 (45.6%) had an ischemic stroke. Of which 41.1% (65/158) were women. The mean age was 60.8±13.3 years. …”
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Weekend effect on in-hospital outcomes of transcatheter aortic valve replacement: insights from a propensity-matched national analysis by Guangzhi Cong, Bo Shi, Xueping Ma, Congyan Ye, Rui Yan, Shizhe Fu, Kairu Wang, Haowei Li, Ru Yan, Shaobin Jia, Israel Gitangaza, Abdul Rehman

“…Moreover, weekend admissions had significantly higher adjusted odds for cardiogenic shock, permanent pacemaker implantation, endocarditis, acute kidney injury, acute ischemic stroke, and blood transfusion. There was a trend of higher in-hospital mortality for weekend over weekday admissions throughout the study period. …”
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Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study by Xiang Xiao, Qiang Lin, Wai-Leung Lo, Yu-Rong Mao, Xin-chong Shi, Ryan S. Cates, Shu-Feng Zhou, Dong-Feng Huang, Le Li

“…Eight participants with ischemic stroke underwent VRET for 5 sections per week and for 3 weeks. fMRI was conducted to quantify the activity of selected brain regions when the subject performed ankle dorsiflexion. …”
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Body Mass Index and 1-Year Unplanned Readmission in Chinese Patients with Acute Myocardial Infarction: A Retrospective Cohort Study by Dandan Sun, Qingyun Zhang, Wei Li, Haichen Wang

“…Covariates involved in this study included age, gender, TC, triglyceride, HDL-C, LDL-C, PT, APTT, INR, creatinine, HGB, LVEF, discharge medication, marital status, educational level, COPD, diabetes mellitus, heart failure, history of ischemic stroke, history of hemorrhagic stroke, arrhythmia, and hypertension. …”
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The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells by Jinju Wang, Runmin Guo, Yi Yang, Bradley Jacobs, Suhong Chen, Ifeanyi Iwuchukwu, Kenneth J. Gaines, Yanfang Chen, Richard Simman, Guiyuan Lv, Keng Wu, Ji C. Bihl

“…The methods had the overall recovery rate of over 70% and were able to detect the dynamical changes of circulating EC-EXs and EPC-EXs in acute ischemic stroke. In conclusion, we have developed sensitive and specific microbeads/Q-dots fluorescence NTA methods for EC-EX and EPC-EX isolation and detection, which will facilitate the functional study and biomarker discovery.…”
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Global magnitude and temporal trends of stroke attributable to lead exposure from 1990 to 2021 by Ying Wang, Ran Liu, Wenxia Li, PengNan Bao, JinWei Zhang, Wei Yue

“…However, ASMRs declined from 9.33 to 6.65 per 100,000 population (EAPC = −1.23), and ASDRs fell from 213.99 to 139.82 per 100,000 population (EAPC = −1.51). Among subtypes, ischemic stroke (IS) contributed the most to ASMRs, whereas intracerebral hemorrhage (ICH) accounted for the highest ASDRs. …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors. This review explores the role of CHI3L1 in the pathogenesis of these disorders, with a focus on its contributions to neuroinflammation, immune cell infiltration, and neuronal degeneration. …”
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Outcomes and safety of mechanical thrombectomy, alteplase, and conventional medical care in the treatment of acute M2 segment middle cerebral artery occlusion: a comparative study by Eman M. Khedr, Ahmed Elbassiouny, Mahmoud Nageeb, Ahmed Aly, Khalid O. Mohamed, Nourelhoda A. Haridy

“…We report the outcome and safety of MT versus intravenous recombinant tissue plasminogen activator (IV rTPA) versus conventional medical treatment (CMT) of acute ischemic stroke (AIS) due to occlusion of the M2 segment of the MCA. …”
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Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…This study reported six cases of cerebrovascular accidents, including ischemic stroke and cerebral hemorrhage, after bevacizumab use. …”
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CYP2C19 Genotype‐Guided Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing a Neurointerventional Procedure by Kayla R. Tunehag, Ashton F. Pearce, Layna P. Fox, George A. Stouffer, Sten Solander, Craig R. Lee

“…ABSTRACT In neurovascular settings, including treatment and prevention of ischemic stroke and prevention of thromboembolic complications after percutaneous neurointerventional procedures, dual antiplatelet therapy with a P2Y12 inhibitor and aspirin is the standard of care. …”
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Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country by Shahan Waheed, Ayaz Ghouse Kalsekar, Ayeesha Kamran Kamal, Nathan S. Bryan, Asad I. Mian

“…Seventy-five patients were enrolled, with median age of 57 years (IQR 47-66 years), 53 (71%) were males, and 46 (61%) had ischemic stroke. Overall, median NOx was 20.8 μM (IQR 13.4-35.3); there was no statistically significant difference between NOx in ischemic versus hemorrhagic stroke (21.2 μM vs. 17.9 μM; p=0.2). …”
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