Embolic Stroke due to a Common Carotid Artery Thrombus in a Young Patient with Severe Iron-Deficiency Anemia without Thrombocytosis by David Roshal

“…This case report suggests that severe iron-deficiency anemia with or without reactive thrombocytosis should be viewed as a possible hematologic condition associated with thrombotic tendencies and a risk factor for ischemic stroke, especially in young adults. Aggressive iron supplementation and short-term antithrombotic therapy with follow-up vascular imaging are a reasonable treatment for these patients.…”
Get full text

Anton’s Syndrome due to Bilateral Ischemic Occipital Lobe Strokes by Sanela Zukić, Osman Sinanović, Lejla Zonić, Renata Hodžić, Svjetlana Mujagić, Edina Smajlović

“…Anton syndrome, is not so frequent condition and is most commonly caused by ischemic stroke. In this particular case, the patient had successive bilateral occipital ischemia as a result of massive stenoses of head and neck arteries.…”
Get full text

Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke by Yongdan Cun, Yaju Jin, Danli Wu, Li Zhou, Chengcai Zhang, Simei Zhang, Xicheng Yang, null Zuhong Wang, Pengyue Zhang

“…The endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke. …”
Get full text

Late Recovery from Severe Streptococcus pneumoniae Comatose Meningitis with Concomitant Diffuse Subcortical Cytotoxic Edema and Cortical Hypometabolism by Philippe Hantson, Thierry Duprez

“…Repeated brain magnetic resonance imaging (MRI) examination failed to demonstrate venous thrombosis, arterial ischemic stroke, or brain abscesses but revealed diffuse but reversible cortical cytotoxic edema at diffusion-weighted (DW) sequences. …”
Get full text

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders by Keren Zhou, Ligen Shi, Yan Wang, Sheng Chen, Jianmin Zhang

“…In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. …”
Get full text

Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…The therapeutic potential of PD-1 agonism in ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage-related vasospasm, and traumatic brain injury rests on the notion of harnessing the immunomodulatory function of immune checkpoint pathways to temper the harmful effects of immune overactivation and secondary injury while promoting repair and recovery. …”
Get full text

Local Thrombolysis for Successful Treatment of Acute Stroke in an Adolescent with Cardiac Myxoma by Natig Gassanov, Amir M. Nia, Kristina M. Dahlem, Stefan Ederer, Inga Wedemeyer, Evren Caglayan, Erland Erdmann, Fikret Er

“…Magnetic resonance imaging of the brain revealed an ischemic stroke without evidence of acute bleeding. Intra-arterial local thrombolysis was immediately started. …”
Get full text

Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura by Zakaria Hindi, Nirmal Onteddu, Christopher A. Ching, Abdallah A. Khaled

“…A 32-year-old female with a history of ITP presented with ischemic stroke. The patient was treated in the hospital with IV immunoglobulin, discharged to a rehabilitation facility, and had complete resolution of symptoms when examined at a follow-up visit 3 months later. …”
Get full text

Septic Embolic Stroke Followed by Hemorrhage and Brain Abscess in a Patient with Systemic Infections: A Case Report and Literature Review by Jama A. Mohamud, Jingtao Wu, Ye Jing, Yu Wang

“…We report a case of 50-year-old man with a severe acute ischemic stroke followed by intracerebral hemorrhage and brain abscess due to systemic infection. …”
Get full text

From memory impairment to two occluders in the heart – a multidisciplinary case report by A. Wiśniewski, K. Filipska, A. Ekkert

“…The impact of stress, migraine, physical effort is also highlighted. In contrast to ischemic stroke, atrial fibrillation (AF) and patent foramen ovale (PFO) are relatively rarely reported in the pathophysiology of acute memory impairment. …”
Get full text

Repeated Intra-Arterial Thrombectomy within 72 Hours in a Patient with a Clear Contraindication for Intravenous Thrombolysis by Mona Laible, Markus Möhlenbruch, Werner Hacke, Martin Bendszus, Peter Arthur Ringleb, Timolaos Rizos

“…Treating patients with acute ischemic stroke, proximal arterial vessel occlusion, and absolute contraindication for administering intravenous recombinant tissue plasminogen activator (rtPA) poses a therapeutic challenge. …”
Get full text

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe. …”
Get full text

Embolic Stroke as the Initial Manifestation of Systemic Lupus Erythematosus by Reshma M. Khan, Rajaie Namas, Sachin Parikh, Bernard Rubin

“…Further workup with imaging of the brain was consistent with an ischemic stroke. Hereditary hypercoagulable workup was unremarkable and initial testing for antiphospholipid syndrome was positive. …”
Get full text

Intracranial Atherosclerotic Disease by Maria Khan, Imama Naqvi, Asha Bansari, Ayeesha Kamran Kamal

“…Intracranial atherosclerotic disease (ICAD) is the most common proximate mechanism of ischemic stroke worldwide. Approximately half of those affected are Asians. …”
Get full text

Unraveling cerebroprotective potential of fenchone: A combined in vivo and in silico exploration of nitric oxide synthase modulation by Bangaru Mamatha, Anka Rao Areti, DSNBK Prasanth, Narender Malothu

“…Overall, the results suggest that FEN plays a neuroprotective role in brain ischemia, potentially through the inhibition of NOS, reduction of oxidative stress, and modulation of antioxidants, highlighting the potential of FEN as a therapeutic candidate for ischemic stroke management.…”
Get full text

Aspirin does not confer protection against major ischemic vascular events in patients diagnosed with rheumatoid arthritis by Chao Gao, Qiqi Hou, Hongxia Cao, Cangtuo Li, Xu Peng, Quanle Han, Shouling Wu, Kangbo Li

“…The risk of ischemic vascular events (myocardial infarction and ischemic stroke) was examined. The relationship between ASA therapy and major ischemic vascular events was analyzed by Cox proportional hazards regression. …”
Get full text

Phosphodiesterase 4 inhibition as a novel treatment for stroke by Jiahong Zhong, Xihui Yu, Zhuomiao Lin

“…The PDE4D gene has been demonstrated to have a positive correlation with the risk of ischemic stroke. Additionally, the utilization of phosphodiesterase 4 inhibitors can enhance synaptic plasticity within the neural circuitry, regulate cellular metabolism, and prevent secondary brain injury caused by impaired blood flow. …”
Get full text

Predicting intracerebral hemorrhage after endovascular therapy for anterior circulation strokes using CT-ASPECT, CTP-ASPECT and DWI-ASPECT: Protocol for a systematic review. by Vincent Brissette, Chirayu Bhatt, Brian Dewar, Risa Shorr, Jordi Pardo, Robert Fahed, Michel Shamy, Dar Dowlatshahi

“…<h4>Introduction</h4>Over the last decade, there have been significant advances in treatments for anterior ischemic stroke, most notably endovascular thrombectomy (EVT). …”
Get full text

Impaired Emotion Recognition after Left Hemispheric Stroke: A Case Report and Brief Review of the Literature by Hugo P. Aben, Yael D. Reijmer, Johanna M. A. Visser-Meily, Jacoba M. Spikman, Geert Jan Biessels, Paul L. M. de Kort, PROCRAS Study Group

“…We describe a case of left hemispheric ischemic stroke with impaired recognition of specifically faces expressing fear. …”
Get full text

PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury by Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Lee

“…The data suggest that H89 may contribute to brain recovery after ischemic stroke by regulating neuronal death and proteins related to synaptic plasticity.…”
Get full text