Screening for Iron Overload: Lessons from the HEmochromatosis and IRon Overload Screening (HEIRS) Study by Paul C Adams, James C Barton, Gordon D McLaren, Ronald T Acton, Mark Speechley, Christine E McLaren, David M Reboussin, Catherine Leiendecker-Foster, Emily L Harris, Beverly M Snively, Thomas Vogt, Phyliss Sholinsky, Elizabeth Thomson, Fitzroy W Dawkins, Victor R Gordeuk, John H Eckfeldt

“…BACKGROUND: The HEmochromatosis and IRon Overload Screening (HEIRS) Study provided data on a racially, ethnically and geographically diverse cohort of participants in North America screened from primary care populations.…”
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Iron Chelators in Treatment of Iron Overload by Sarina Entezari, Seyedeh Mona Haghi, Narges Norouzkhani, Barsa Sahebnazar, Fatemeh Vosoughian, Diba Akbarzadeh, Muhammad Islampanah, Navid Naghsh, Mohammad Abbasalizadeh, Niloofar Deravi

“…Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. …”
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Effects of Curcumin on Iron Overload in Rats by Gülüzar Özbolat, Arash Alizadeh Yegani

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Cardiac injury caused by iron overload in thalassemia by Chunxi Fu, Chunxi Fu, Xue Yang, Xue Yang

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Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients by Pandji Irani Fianza, Anita Rahmawati, Sri Hudaya Widihastha, Shofura Afifah, Mohammad Ghozali, Andre Indrajaya, Dilli Marayuzan Akbar Pratama, Dimmy Prasetya, Teddy Arnold Sihite, Mas Rizky A. A. Syamsunarno, Djatnika Setiabudi, Suthat Fucharoen, Ramdan Panigoro

“…However, there have been known transfusions-related consequences, including iron overload and multi-organ damage. The aims of this study were to evaluate liver and cardiac function in youth and adult transfusion-dependent Indonesian thalassemic patients and to assess its correlation with serum ferritin levels, as well as T2∗magnetic resonance imaging (MRI). …”
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Spontaneous Yersinia enterocolitica Septicemia in a Patient with Iron Overload by Steven S Larigakis, Michael A Noble, Terence G Sparling

“…Yersinia enterocolitica septicemia is described in a patient with transfusional iron overload and a myelodysplastic syndrome. The organism was biotype 1 serotype 0:5,27 and carried a virulence-encoding plasmid. …”
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𝛽-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload by Luca Melchiori, Sara Gardenghi, Stefano Rivella

“…The sequelae of IE lead to extramedullary hematopoiesis (EMH) with massive splenomegaly and dramatic iron overload, which in turn is responsible for many of the secondary pathologies observed in thalassemic patients. …”
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Effect of a high-fat diet and iron overload on erythropoiesis in mice by Joe Varghese, Jithu James Varghese, Molly Jacob

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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

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Mycobacterium avium Complex Infection in a Patient with Sickle Cell Disease and Severe Iron Overload by Kamal Shemisa, Nasima Jafferjee, David Thomas, Gretta Jacobs, Howard J. Meyerson

“…A 34-year-old female with sickle cell anemia (hemoglobin SS disease) and severe iron overload presented to our institution with the subacute presentation of recurrent pain crisis, fever of unknown origin, pancytopenia, and weight loss. …”
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Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators by Orish Ebere Orisakwe, Cecilia Nwadiuto Amadi, Chiara Frazzoli

“…Although bloodletting or phlebotomy remains the gold standard in the management of iron overload, this systematic review is an updated account of the pitfalls of phlebotomy and classical synthetic chelators with scientific justification for the use of natural iron chelators of dietary origin in resource-poor nations.…”
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Relationship between cognitive impairment and hippocampal iron overload: A quantitative susceptibility mapping study of a rat model by Xi Deng, Meiru Bu, Jiali Liang, Yihao Sun, Liyan Li, Heishu Zheng, Zisan Zeng, Muliang Jiang, Bihong T. Chen

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Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction by Yasuo Miura, Yusuke Matsui, Hitomi Kaneko, Mitsumasa Watanabe, Mitsuru Tsudo

“…We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT). …”
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Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes by Amedeo Lonardo

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Hyperferritinemia at the patient with chronic hepatitis C by Ye. N. German, A. O. Buyeverov, M. V. Mayevskaya, Ch. S. Pavlov, V. T. Ivashkin, A. A. Levina

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Study of vascular endothelial dysfunction in children with beta-thalassemia major before and after quercetin therapy by Fatma Al Zahraa Sherai, Maaly Mabrouk, Ibrahim Badraia, Adel Hagag, Eman Elaskary

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Iron overload impact on peripheral blood cells, lymphocytes and karyotypes in newly diagnosed myelodysplastic syndromes (MDS) patients: a single-center retrospective analysis by Lixiang Duan, Wenjun Yu, Xiaolin Jiao, Ying Sun, Yao Fang Ma, Le Li, Zeqiang Nie, Dan Zhao

Subjects: “…iron overload…”
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Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway by Lei Huang, Zhaoyun Liu, Hui Liu, Kai Ding, Fu Mi, Chenhuan Xiang, Guanrou Wang, Yixuan Guo, Rong Fu

“…The higher incidence of ASXL1 and TET2 gene mutations in our iron overload (IO) MDS patients suggests that IO may be involved in the pathogenesis of MDS. …”
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The effect of blood transfusion on serum hepcidin levels in chronically transfused patients of β-thalassemia major: An observational study in a tertiary care centre in Western Maha... by Sujay Bhowmik, Amit Kumar Biswas, Ajay Kumar Baranwal, Amit Ajay Pawar, Ujjwal Dimri

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Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

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