Multisystem inflammatory syndrome in children with COVID-19 in a multitransfused patient by Swarnalata Das, Manas Behera Ranjan, Palash Das

“…Diagnosis of MIS-C in the background of transfusion dependent thalassemia with iron overload needs a strong clinical suspicion. Early diagnosis and prompt treatment are necessary to ensure a rapid uneventful recovery. …”
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Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana by Christian Obirikorang, Razak Gyesi Issahaku, Derick Nii Mensah Osakunor, James Osei-Yeboah

“…Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). …”
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Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress by Paraskevi Roussou, Nikolaos J. Tsagarakis, Dimitrios Kountouras, Sarantis Livadas, Evanthia Diamanti-Kandarakis

“…Meanwhile, a significant prooxidants/antioxidants imbalance with subsequent increased (OS) exists in patients with BTM, which is mainly caused by tissue injury due to overproduction of free radicals by secondary iron overload, but also due to alteration in serum trace elements and antioxidant enzymes. …”
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Glycosylated lysosomal membrane protein promotes tissue repair after spinal cord injury by reducing iron deposition and ferroptosis in microglia by Fangru Ouyang, Meige Zheng, Jianjian Li, Jinxin Huang, Jianan Ye, Jingwen Wang, Yuanzhe Zhao, Fangli Shan, Ziyu Li, Shuishen Yu, Fei Yao, Dasheng Tian, Li Cheng, Juehua Jing

“…Our findings highlight the crucial role of GLMP in mitigating iron overload and ferroptosis in microglia, thereby contributing to axon retention and locomotor recovery after SCI.…”
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Infusion of Autologous Retrodifferentiated Stem Cells into Patients with Beta-Thalassemia by Ilham Saleh Abuljadayel, Tasnim Ahsan, Huma Quereshi, Shakil Rizvi, Tamseela Ahmed, Sabiha Mirza Khan, Jawaid Akhtar, Ghazi Dhoot

“…Current treatment of this disease involves regular blood transfusion and adjunct chelation therapy to lower blood transfusion–induced iron overload. Fetal hemoglobin switching agents have been proposed to treat genetic blood disorders, such as sickle cell anemia and beta-thalassemia, in an effort to compensate for the dysfunctional form of the beta-globin chain in adult hemoglobin. …”
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MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma by Peng Xu, Fei-Hang Ge, Wen-Xin Li, Zhen Xu, Xue-Li Wang, Jing-Lan Shen, Ai-Bo Xu, Rong-Rong Hao

“…Mechanistically, we determined that miR-147a directly bound to the 3′-untranslated region of SLC40A1 and inhibited SLC40A1-mediated iron export, thereby facilitating iron overload, lipid peroxidation, and ferroptosis. Furthermore, miR-147a mimic-treated human glioblastoma cells exhibited higher sensitivity to TMZ chemotherapy than those treated with the mimic control in vitro. …”
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Clinical Study of Mobile Application- (App-) Based Family-Centered Care (FCC) Model Combined with Comprehensive Iron Removal Treatment in Children with Severe Beta Thalassemia by Yuke Chen, Xiuping Huang, Qingmei Lu, Jian Lu, Xiaoxiao Huang, Yanni Luo, Fengxing Huang

“…The difficulties of iron overload caused by transfusions, which are the foundation of illness management in the majority of patients with severe thalassemia, may further worsen the clinical features. …”
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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice by Mengjie Liu, Zhenlin Li, Jie Li, Guorong Yan, Chaoqi Liu, Qingqiang Yin, Yeqiang Liu, Xiaoxiang Xu

“…Additionally, COS inhibited ferroptosis by modulating the SLC7A11/GSH/GPX4 pathway and the expression of FTH1 and FLC proteins, thereby reducing lipid peroxidation accumulation and iron overload. In summary, this research showed that COS mitigated DON-induced liver injury in mice by alleviating DON-induced oxidative stress, inflammation, apoptosis, and ferroptosis via modulating the Nrf2/HO-1/NF-κB and GPX4 signaling pathways. …”
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

“…Puerarin also ameliorated hepatic pathological changes and inflammatory responses, and attenuated oxidative stress and iron overload in KKAy mice. Western blotting results showed that Puerarin could regulate the expression of proteins related to JAK2/STAT3 pathway and ferroptosis pathway. …”
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Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis by Judith Giroud-Gerbetant, Fernando Sotillo, Gonzalo Hernández, Irene Ruano, David Sebastián, Joana Fort, Mayka Sánchez, Günter Weiss, Neus Prats, Antonio Zorzano, Manuel Palacín, Susanna Bodoy

“…Further investigation indicated that defective erythropoiesis is linked to impaired erythropoietin production in the kidney and subsequent iron overload. Conclusions The hematopoietic defects in the Lysinuric protein intolerance mouse model are not caused by intrinsic Slc7a7 loss in hematopoietic cells but rather by impaired erythropoietin production in the kidney. …”
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Impact of iron chelation with deferasirox on telomere length and oxidative stress in hemodialysis patients: A randomized study by Blanca Olivia Murillo Ortiz, Joel Ramírez Emiliano, Marcos Javier Romero Vázquez, Lauro Fabián Amador Medina, Sandra Martínez Garza, Edna Montserrat Ramos Rodríguez

“…Deferasirox proves to be beneficial for patients with iron overload undergoing hemodialysis. Resumen: Antecedentes: Estudios recientes han demostrado la eficacia, seguridad y tolerabilidad del deferasirox en pacientes en diálisis peritoneal, sin embargo, su efecto no ha sido estudiado en pacientes sometidos a hemodiálisis. …”
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Iron Loading and Overloading due to Ineffective Erythropoiesis by Toshihiko Tanno, Jeffery L. Miller

“…The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. …”
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