Durable Red Blood Cell Transfusion Independence in a Patient with an MDS/MPN Overlap Syndrome Following Discontinuation of Iron Chelation Therapy by Harpreet Kochhar, Chantal S. Leger, Heather A. Leitch

“…Hematologic improvement (HI) occurs in some patients with acquired anemias and transfusional iron overload receiving iron chelation therapy (ICT) but there is little information on transfusion status after stopping chelation. …”
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Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature by Q. Shazia, Z. H. Mohammad, Taibur Rahman, Hossain Uddin Shekhar

“…This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essential trace element levels. …”
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Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015 by Hadi Darvishi Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Aily Aliasgharian, Hossein Jalali, Arash Hadian Amree

“…Without iron chelation therapy, iron overload will cause lots of complications in patients. …”
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The Toxic Influence of Excess Free Iron on Red Blood Cells in the Biophysical Experiment: An In Vitro Study by E. Kozlova, E. Sherstyukova, V. Sergunova, A. Kozlov, O. Gudkova, V. Inozemtsev, A. Chernysh

“…Iron is needed for life-essential processes, but free iron overload causes dangerous clinical consequences. …”
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MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1 by Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng

“…The miR-4735-3p mimic increased, while the miR-4735-3p inhibitor decreased oxidative stress, lipid peroxidation, iron overload, and ferroptosis of human ccRCC cell lines. …”
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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism by Angela Vidal, Carolin Dhakal

“…Because of the various treatments, a secondary endocrinopathy due to iron overload—haemosiderosis—can occur, causing hypopituitarism leading to hypogonadotropic hypogonadism (HH) and infertility. …”
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Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C by Hironori Mitsuyoshi, Kohichiroh Yasui, Kanji Yamaguchi, Masahito Minami, Takeshi Okanoue, Yoshito Itoh

“…Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. …”
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The Role of Iron in the Pathophysiology and Treatment of Chronic Hepatitis C by Leslie Price, Kris V Kowdley

“…The present article reviews the prevalence and risk factors for hepatic iron overload in chronic hepatitis C, with emphasis on the available data regarding the efficacy of iron depletion in the treatment of this common liver disease.…”
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Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias by Elizabeta Nemeth

“…Deficient production of hepcidin causes systemic iron overload in iron-loading anemias such as beta-thalassemia; whereas hepcidin excess contributes to the development of anemia in inflammatory disorders and chronic kidney disease, and may cause erythropoietin resistance. …”
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Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families by Elisa Fermo, Cristina Vercellati, Anna Paola Marcello, Anna Zaninoni, Richard van Wijk, Nadia Mirra, Cristina Curcio, Agostino Cortelezzi, Alberto Zanella, Wilma Barcellini, Paola Bianchi

“…Hereditary xerocytosis (HX) is a rare disorder caused by defects of RBC permeability, associated with haemolytic anaemia of variable degree and iron overload. It is sometimes misdiagnosed as hereditary spherocytosis or other congenital haemolytic anaemia. …”
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A Point Mutation in the Iron-Responsive Element of the L-Ferritin in a Family with Hereditary Hyperferritinemia Cataract Syndrome by Karen Wong, Yousef Barbin, Subrata Chakrabarti, Paul Adams

“…BACKGROUND: Hereditary hyperferritinemia cataract syndrome is an autosomal dominant condition that is characterized by a high serum ferritin level and bilateral early-onset cataracts in the absence of iron overload. The genetic abnormality is identified as a mutation in the 5' regulatory region of the L-ferritin messenger RNA known as the iron-responsive element (IRE). …”
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HFE-Associated Hereditary Haemochromatosis by Emmeke J Eijkelkamp, Thomas R Yapp, Lawrie W Powell

“…Although the basic defect is still not fully understood, much is known about the sequence of events leading to iron overload.…”
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Prevention of Cardiomyopathy in Transfusion-Dependent Homozygous Thalassaemia Today and the Role of Cardiac Magnetic Resonance Imaging by Athanassios Aessopos, Vasilios Berdoukas, Maria Tsironi

“…Recently the ability to determine the degree of cardiac iron overload, through cardiac magnetic resonance imaging (CMR) has allowed more logical approaches to iron removal, particularly from the heart. …”
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Cellular Reprogramming toward the Erythroid Lineage by Laura J. Norton, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley

“…These treatments are ongoing throughout the life of the patient and are associated with a number of risks, such as limitations in available blood for transfusion, infections, iron overload, immune rejection, and side effects associated with the drug treatments. …”
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Uptake of Non-Transferrin Iron by Erythroid Cells by Eugenia Prus, Eitan Fibach

“…Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron. …”
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Regulation of Hippo-YAP1/TAZ pathway in metabolic dysfunction-associated steatotic liver disease by Wei Xuan, Dandan Song, Jianghua Hou, Xiuping Meng

“…Metabolic disorders such as iron overload, glycolysis, insulin resistance, lipid dysregulation, and glutaminolysis are found to induce liver senescence and ferroptosis, which are hot topics in the research of MASLD. …”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. …”
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Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity by O. A. Smirnov

“…Expression peptide mRNA in hepatocytes is induced by proinflammatory cytokines (IL-1α, IL-6 and TNF-α) similar to acute phase proteins of inflammation, and also by liver iron overload. Hepcidin promotes elevation of natural resistance of the body to infection, first of all due to direct bactericidal effect. …”
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Role of ferroptosis in atrial fibrillation: a review by Shaowei Fan, Yuanhui Hu, Jingjing Shi

“…Ferroptosis, a recently discovered form of regulated cell death characterized by lipid peroxidation and disrupted cellular redox balance leading to cell death due to iron overload, has attracted significant attention. Since its identification, ferroptosis has been extensively studied in various contexts, including cancer, stroke, myocardial ischemia/reperfusion injury, and heart failure. …”
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Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis by Del Corso Lisette, Balleari Enrico, Arboscello Eleonora, Ghio Riccardo, Mencoboni Manlio, Racchi Omar

“…Both anemia and transfusion-dependence are associated with a poor outcome, at least in part because of toxic effects of iron overload (IOL). Iron-chelating therapy (ICT) is increasingly used in order to prevent IOL in this setting. …”
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