A Point Mutation in the Iron-Responsive Element of the L-Ferritin in a Family with Hereditary Hyperferritinemia Cataract Syndrome by Karen Wong, Yousef Barbin, Subrata Chakrabarti, Paul Adams

“…BACKGROUND: Hereditary hyperferritinemia cataract syndrome is an autosomal dominant condition that is characterized by a high serum ferritin level and bilateral early-onset cataracts in the absence of iron overload. The genetic abnormality is identified as a mutation in the 5' regulatory region of the L-ferritin messenger RNA known as the iron-responsive element (IRE). …”
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HFE-Associated Hereditary Haemochromatosis by Emmeke J Eijkelkamp, Thomas R Yapp, Lawrie W Powell

“…Although the basic defect is still not fully understood, much is known about the sequence of events leading to iron overload.…”
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Prevention of Cardiomyopathy in Transfusion-Dependent Homozygous Thalassaemia Today and the Role of Cardiac Magnetic Resonance Imaging by Athanassios Aessopos, Vasilios Berdoukas, Maria Tsironi

“…Recently the ability to determine the degree of cardiac iron overload, through cardiac magnetic resonance imaging (CMR) has allowed more logical approaches to iron removal, particularly from the heart. …”
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Cellular Reprogramming toward the Erythroid Lineage by Laura J. Norton, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley

“…These treatments are ongoing throughout the life of the patient and are associated with a number of risks, such as limitations in available blood for transfusion, infections, iron overload, immune rejection, and side effects associated with the drug treatments. …”
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Uptake of Non-Transferrin Iron by Erythroid Cells by Eugenia Prus, Eitan Fibach

“…Under pathological conditions of iron-overload, the plasma iron which is in excess of the binding capacity of Tf is present as non-Tf-bound iron. …”
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Regulation of Hippo-YAP1/TAZ pathway in metabolic dysfunction-associated steatotic liver disease by Wei Xuan, Dandan Song, Jianghua Hou, Xiuping Meng

“…Metabolic disorders such as iron overload, glycolysis, insulin resistance, lipid dysregulation, and glutaminolysis are found to induce liver senescence and ferroptosis, which are hot topics in the research of MASLD. …”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iron overload, decreased insulin secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome. …”
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Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity by O. A. Smirnov

“…Expression peptide mRNA in hepatocytes is induced by proinflammatory cytokines (IL-1α, IL-6 and TNF-α) similar to acute phase proteins of inflammation, and also by liver iron overload. Hepcidin promotes elevation of natural resistance of the body to infection, first of all due to direct bactericidal effect. …”
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Role of ferroptosis in atrial fibrillation: a review by Shaowei Fan, Yuanhui Hu, Jingjing Shi

“…Ferroptosis, a recently discovered form of regulated cell death characterized by lipid peroxidation and disrupted cellular redox balance leading to cell death due to iron overload, has attracted significant attention. Since its identification, ferroptosis has been extensively studied in various contexts, including cancer, stroke, myocardial ischemia/reperfusion injury, and heart failure. …”
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Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis by Del Corso Lisette, Balleari Enrico, Arboscello Eleonora, Ghio Riccardo, Mencoboni Manlio, Racchi Omar

“…Both anemia and transfusion-dependence are associated with a poor outcome, at least in part because of toxic effects of iron overload (IOL). Iron-chelating therapy (ICT) is increasingly used in order to prevent IOL in this setting. …”
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Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…A small fraction (14.23%) has undergone splenectomy, while the percentage of patients with severe iron overload (serum ferritin ≥5000 µg/L) reduced over time. …”
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Red Blood Cell Transfusion Independence Following the Initiation of Iron Chelation Therapy in Myelodysplastic Syndrome by Maha A. Badawi, Linda M. Vickars, Jocelyn M. Chase, Heather A. Leitch

“…Iron chelation therapy is often used to treat iron overload in patients requiring transfusion of red blood cells (RBC). …”
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Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog by Ethan A. Natelson, David Pyatt

“…They are typically considered neoplasms because of frequent genetic aberrations and patient-limited survival with progression to acute myeloid leukemia (AML) or death related to the consequences of bone marrow failure including infection, hemorrhage, and iron overload. A progression to AML has always been recognized among the myeloproliferative disorders (MPD) but occurs only rarely among those with essential thrombocythemia (ET). …”
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Zygomycosis in Two Hematologic Cases by M. T. García-Romero, J. García-Méndez, R. Arenas, T. Ferrari-Carballo, J. Chanona-Vilchis, E. Cervera-Ceballos

“…Most of the cases published are in patients with prolonged neutropenia, along with other risk factors such as the use of prior broad-spectrum antibiotics (including new antifungal agents, such as voriconazole), diabetes mellitus (with or without ketoacidosis), malnutrition, iron overload (with or without the use of deferoxamine). …”
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Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway by Yingang Li, Xizhuang Bai

“…In this study, we found that naringenin significantly reduced the viability of osteosarcoma cells while increasing the accumulation of reactive oxygen species (ROS), iron overload, and the excessive expression of malondialdehyde (MDA). …”
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Cardiac Failure after Liver Transplantation Requiring a Biventricular Assist Device by Rita Jermyn, Eiei Soe, David D’Alessandro, Julia Shin, William Jakobleff, Daniel Schwartz, Milan Kinkhabwala, Paul J. Gaglio

“…Hepatic as well as nonhepatic iron overload is associated with increased infectious and postoperative complications, including cardiac dysfunction. …”
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Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway by Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang

“…Ferroptosis was identified in mice with UC, as demonstrated by mitochondrial disruption, MDA and ROS production, iron overload, decrease in GSH level, and abnormal expression of core marker proteins of ferroptosis. …”
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ER Stress and Iron Homeostasis: A New Frontier for the UPR by Susana J. Oliveira, Maria de Sousa, Jorge P. Pinto

“…The C282Y mutation of HFE accounts for the majority of cases of the iron overload disease Hereditary Hemochromatosis (HH). …”
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Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers by Vincenzo Russo, Enrico Melillo, Andrea A. Papa, Anna Rago, Celeste Chamberland, Gerardo Nigro

“…Cardiac complications represent a leading cause of mortality in β-TM patients, although an important and progressive increase of life expectancy has been demonstrated after the introduction of chelating therapies. Iron overload is the primary factor of cardiac damage resulting in thalassemic cardiomyopathy, in which diastolic dysfunction usually happens before systolic impairment and overt heart failure (HF). …”
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Physiopathology of Bone Modifications in β-Thalassemia by Carlo Perisano, Emanuele Marzetti, Maria Silvia Spinelli, Cinzia Anna Maria Callà, Calogero Graci, Giulio Maccauro

“…The abnormal regulation of bone metabolism may be related to hormonal and genetic factors, iron overload and iron chelation therapy, nutritional deficits, and decreased levels of physical activity. …”
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